Effects of different doses of remimazolam besylate on postoperative sedation, pain, and adverse reactions in patients undergoing hysteroscopic surgery
Abstract Background Hysteroscopy, a minimally invasive gynecological procedure, requires effective sedation for patient comfort and surgical success. Remimazolam Besylate, a new ultra-short-acting benzodiazepine, offers potential for safe sedation, but the optimal dose for postoperative outcomes is...
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BMC
2025-07-01
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| Series: | BMC Surgery |
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| Online Access: | https://doi.org/10.1186/s12893-025-03017-1 |
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| author | Linjiang Yang Liang Zhong Xu Deng Hao Fang Siqin Li Yi Li |
| author_facet | Linjiang Yang Liang Zhong Xu Deng Hao Fang Siqin Li Yi Li |
| author_sort | Linjiang Yang |
| collection | DOAJ |
| description | Abstract Background Hysteroscopy, a minimally invasive gynecological procedure, requires effective sedation for patient comfort and surgical success. Remimazolam Besylate, a new ultra-short-acting benzodiazepine, offers potential for safe sedation, but the optimal dose for postoperative outcomes is unclear. This study evaluated the effects of different doses of Remimazolam Besylate on postoperative sedation, pain, and adverse reactions in hysteroscopic surgery patients. Methods From June 2020 to June 2022, 90 patients undergoing hysteroscopic surgery under general anesthesia were randomly divided into three subgroups (A, B, C; n = 30 each). Subgroup A received 0.2 mg/kg, Subgroup B received 0.3 mg/kg, and Subgroup C received 0.4 mg/kg of Remimazolam Besylate intravenously during anesthesia induction. Postoperative outcomes, including pain stress mediators (PGE2 and 5-HT), Pain Visual Analogue Scale (VAS) scores, Ramsay Sedation scores, and adverse events, were compared among the subgroups. Results Subgroup A (0.2 mg/kg) showed significantly higher levels of PGE2 and 5-HT at 2, 12, and 24 h postoperatively compared to Subgroups B (0.3 mg/kg) and C (0.4 mg/kg). VAS scores at 2 and 12 h were higher in Subgroup A, while Ramsay Sedation scores were lower. Subgroup C had a significantly higher incidence of adverse reactions compared to Subgroups A and B. Conclusion Remimazolam Besylate at a dose of 0.3 mg/kg is optimal for anesthesia induction in hysteroscopic surgery, providing effective sedation, reduced postoperative pain, and a lower incidence of adverse reactions compared to higher doses. This dose is recommended for achieving balanced sedation and safety outcomes. |
| format | Article |
| id | doaj-art-d120f99f7f7c437490aa6e16c3edf22e |
| institution | Kabale University |
| issn | 1471-2482 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Surgery |
| spelling | doaj-art-d120f99f7f7c437490aa6e16c3edf22e2025-08-20T03:45:24ZengBMCBMC Surgery1471-24822025-07-0125111010.1186/s12893-025-03017-1Effects of different doses of remimazolam besylate on postoperative sedation, pain, and adverse reactions in patients undergoing hysteroscopic surgeryLinjiang Yang0Liang Zhong1Xu Deng2Hao Fang3Siqin Li4Yi Li5Department of anesthesiology, Tongji Medical College, Wuhan Children’s hospital Wuhan Meternal and Child Healthcare Hospital, Huazhong University of Science & TechnologyDepartment of anesthesiology, Tongji Medical College, Wuhan Children’s hospital Wuhan Meternal and Child Healthcare Hospital, Huazhong University of Science & TechnologyDepartment of anesthesiology, Tongji Medical College, Wuhan Children’s hospital Wuhan Meternal and Child Healthcare Hospital, Huazhong University of Science & TechnologyDepartment of anesthesiology, Tongji Medical College, Wuhan Children’s hospital Wuhan Meternal and Child Healthcare Hospital, Huazhong University of Science & TechnologyDepartment of anesthesiology, Tongji Medical College, Wuhan Children’s hospital Wuhan Meternal and Child Healthcare Hospital, Huazhong University of Science & TechnologyDepartment of anesthesiology, Tongji Medical College, Wuhan Children’s hospital Wuhan Meternal and Child Healthcare Hospital, Huazhong University of Science & TechnologyAbstract Background Hysteroscopy, a minimally invasive gynecological procedure, requires effective sedation for patient comfort and surgical success. Remimazolam Besylate, a new ultra-short-acting benzodiazepine, offers potential for safe sedation, but the optimal dose for postoperative outcomes is unclear. This study evaluated the effects of different doses of Remimazolam Besylate on postoperative sedation, pain, and adverse reactions in hysteroscopic surgery patients. Methods From June 2020 to June 2022, 90 patients undergoing hysteroscopic surgery under general anesthesia were randomly divided into three subgroups (A, B, C; n = 30 each). Subgroup A received 0.2 mg/kg, Subgroup B received 0.3 mg/kg, and Subgroup C received 0.4 mg/kg of Remimazolam Besylate intravenously during anesthesia induction. Postoperative outcomes, including pain stress mediators (PGE2 and 5-HT), Pain Visual Analogue Scale (VAS) scores, Ramsay Sedation scores, and adverse events, were compared among the subgroups. Results Subgroup A (0.2 mg/kg) showed significantly higher levels of PGE2 and 5-HT at 2, 12, and 24 h postoperatively compared to Subgroups B (0.3 mg/kg) and C (0.4 mg/kg). VAS scores at 2 and 12 h were higher in Subgroup A, while Ramsay Sedation scores were lower. Subgroup C had a significantly higher incidence of adverse reactions compared to Subgroups A and B. Conclusion Remimazolam Besylate at a dose of 0.3 mg/kg is optimal for anesthesia induction in hysteroscopic surgery, providing effective sedation, reduced postoperative pain, and a lower incidence of adverse reactions compared to higher doses. This dose is recommended for achieving balanced sedation and safety outcomes.https://doi.org/10.1186/s12893-025-03017-1Remimazolam besylateHysteroscopic surgeryPostoperative sedationPain stress mediatorsAdverse reactions |
| spellingShingle | Linjiang Yang Liang Zhong Xu Deng Hao Fang Siqin Li Yi Li Effects of different doses of remimazolam besylate on postoperative sedation, pain, and adverse reactions in patients undergoing hysteroscopic surgery BMC Surgery Remimazolam besylate Hysteroscopic surgery Postoperative sedation Pain stress mediators Adverse reactions |
| title | Effects of different doses of remimazolam besylate on postoperative sedation, pain, and adverse reactions in patients undergoing hysteroscopic surgery |
| title_full | Effects of different doses of remimazolam besylate on postoperative sedation, pain, and adverse reactions in patients undergoing hysteroscopic surgery |
| title_fullStr | Effects of different doses of remimazolam besylate on postoperative sedation, pain, and adverse reactions in patients undergoing hysteroscopic surgery |
| title_full_unstemmed | Effects of different doses of remimazolam besylate on postoperative sedation, pain, and adverse reactions in patients undergoing hysteroscopic surgery |
| title_short | Effects of different doses of remimazolam besylate on postoperative sedation, pain, and adverse reactions in patients undergoing hysteroscopic surgery |
| title_sort | effects of different doses of remimazolam besylate on postoperative sedation pain and adverse reactions in patients undergoing hysteroscopic surgery |
| topic | Remimazolam besylate Hysteroscopic surgery Postoperative sedation Pain stress mediators Adverse reactions |
| url | https://doi.org/10.1186/s12893-025-03017-1 |
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