Real-world characteristics and treatment patterns in essential thrombocythemia: a population-based cross-sectional study in Taiwan between 2020 and 2021
Background: Essential thrombocythemia (ET) is a Philadelphia chromosome-negative myeloproliferative neoplasm that is characterized by thrombocytosis and an elevated risk of thrombosis and hemorrhage. We aimed to ascertain the demographics, treatment patterns, and risk of recurrent thrombosis among p...
Saved in:
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
SAGE Publishing
2025-07-01
|
| Series: | Therapeutic Advances in Hematology |
| Online Access: | https://doi.org/10.1177/20406207251359651 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849729700436377600 |
|---|---|
| author | Ming-Sun Yu Lennex Hsueh-Lin Yu Shih-Hao Huang Tsung-Hsien Tsai Alex Jia-Hong Lin Josef T. Prchal Min-Chi Chen Kuan-Der Lee |
| author_facet | Ming-Sun Yu Lennex Hsueh-Lin Yu Shih-Hao Huang Tsung-Hsien Tsai Alex Jia-Hong Lin Josef T. Prchal Min-Chi Chen Kuan-Der Lee |
| author_sort | Ming-Sun Yu |
| collection | DOAJ |
| description | Background: Essential thrombocythemia (ET) is a Philadelphia chromosome-negative myeloproliferative neoplasm that is characterized by thrombocytosis and an elevated risk of thrombosis and hemorrhage. We aimed to ascertain the demographics, treatment patterns, and risk of recurrent thrombosis among patients with ET in Taiwan. Objectives: To investigate the patient characteristics, proportion of treatment, age-specific treatment pattern, average daily dose, and risk of recurrence of thrombosis in patients with ET. Design: A population-based cross-sectional study was conducted between January 1, 2020 and December 31, 2021. Methods: This study utilized data from the National Health Insurance Research Database in Taiwan. Patients with ET were identified based on ICD-10-CM codes, and their demographic, clinical, and treatment data were analyzed. Descriptive and statistical analyses were employed to compare patient characteristics, treatment modalities, and recurrence of thrombotic events. Results: Among the 4503 patients with ET (prevalence: 19.3 cases per 100,000 population), the mean age was 58.1 years, with a female predominance (60.3%). Thrombosis occurred in 3.8% of patients during the study period, with a recurrence rate of 30.5% in patients with a history of thrombosis. Hydroxyurea (46.8%) and anagrelide (30.2%) were the most common treatments, with younger patients receiving higher therapeutic doses. Despite cytoreductive therapy, younger patients demonstrated higher recurrence rates of thrombosis. The cumulative incidences of secondary myelofibrosis and acute myeloid leukemia were 2.6% and 0.6%, respectively, over 2 years. Conclusion: This study highlights the burden of ET in Taiwan and reveals significant unmet needs in thrombosis prevention, particularly among younger patients. Real-world treatment patterns diverge from recommendations in guidelines, and this finding emphasizes the need for individualized therapeutic strategies to optimize patient outcomes. Further research, such as a longitudinal study, is warranted to investigate the risk factors of thrombosis, disease progression, and mortality in this cohort. |
| format | Article |
| id | doaj-art-d1206f287f7f4a2dbfa802b138783660 |
| institution | DOAJ |
| issn | 2040-6215 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Therapeutic Advances in Hematology |
| spelling | doaj-art-d1206f287f7f4a2dbfa802b1387836602025-08-20T03:09:07ZengSAGE PublishingTherapeutic Advances in Hematology2040-62152025-07-011610.1177/20406207251359651Real-world characteristics and treatment patterns in essential thrombocythemia: a population-based cross-sectional study in Taiwan between 2020 and 2021Ming-Sun YuLennex Hsueh-Lin YuShih-Hao HuangTsung-Hsien TsaiAlex Jia-Hong LinJosef T. PrchalMin-Chi ChenKuan-Der LeeBackground: Essential thrombocythemia (ET) is a Philadelphia chromosome-negative myeloproliferative neoplasm that is characterized by thrombocytosis and an elevated risk of thrombosis and hemorrhage. We aimed to ascertain the demographics, treatment patterns, and risk of recurrent thrombosis among patients with ET in Taiwan. Objectives: To investigate the patient characteristics, proportion of treatment, age-specific treatment pattern, average daily dose, and risk of recurrence of thrombosis in patients with ET. Design: A population-based cross-sectional study was conducted between January 1, 2020 and December 31, 2021. Methods: This study utilized data from the National Health Insurance Research Database in Taiwan. Patients with ET were identified based on ICD-10-CM codes, and their demographic, clinical, and treatment data were analyzed. Descriptive and statistical analyses were employed to compare patient characteristics, treatment modalities, and recurrence of thrombotic events. Results: Among the 4503 patients with ET (prevalence: 19.3 cases per 100,000 population), the mean age was 58.1 years, with a female predominance (60.3%). Thrombosis occurred in 3.8% of patients during the study period, with a recurrence rate of 30.5% in patients with a history of thrombosis. Hydroxyurea (46.8%) and anagrelide (30.2%) were the most common treatments, with younger patients receiving higher therapeutic doses. Despite cytoreductive therapy, younger patients demonstrated higher recurrence rates of thrombosis. The cumulative incidences of secondary myelofibrosis and acute myeloid leukemia were 2.6% and 0.6%, respectively, over 2 years. Conclusion: This study highlights the burden of ET in Taiwan and reveals significant unmet needs in thrombosis prevention, particularly among younger patients. Real-world treatment patterns diverge from recommendations in guidelines, and this finding emphasizes the need for individualized therapeutic strategies to optimize patient outcomes. Further research, such as a longitudinal study, is warranted to investigate the risk factors of thrombosis, disease progression, and mortality in this cohort.https://doi.org/10.1177/20406207251359651 |
| spellingShingle | Ming-Sun Yu Lennex Hsueh-Lin Yu Shih-Hao Huang Tsung-Hsien Tsai Alex Jia-Hong Lin Josef T. Prchal Min-Chi Chen Kuan-Der Lee Real-world characteristics and treatment patterns in essential thrombocythemia: a population-based cross-sectional study in Taiwan between 2020 and 2021 Therapeutic Advances in Hematology |
| title | Real-world characteristics and treatment patterns in essential thrombocythemia: a population-based cross-sectional study in Taiwan between 2020 and 2021 |
| title_full | Real-world characteristics and treatment patterns in essential thrombocythemia: a population-based cross-sectional study in Taiwan between 2020 and 2021 |
| title_fullStr | Real-world characteristics and treatment patterns in essential thrombocythemia: a population-based cross-sectional study in Taiwan between 2020 and 2021 |
| title_full_unstemmed | Real-world characteristics and treatment patterns in essential thrombocythemia: a population-based cross-sectional study in Taiwan between 2020 and 2021 |
| title_short | Real-world characteristics and treatment patterns in essential thrombocythemia: a population-based cross-sectional study in Taiwan between 2020 and 2021 |
| title_sort | real world characteristics and treatment patterns in essential thrombocythemia a population based cross sectional study in taiwan between 2020 and 2021 |
| url | https://doi.org/10.1177/20406207251359651 |
| work_keys_str_mv | AT mingsunyu realworldcharacteristicsandtreatmentpatternsinessentialthrombocythemiaapopulationbasedcrosssectionalstudyintaiwanbetween2020and2021 AT lennexhsuehlinyu realworldcharacteristicsandtreatmentpatternsinessentialthrombocythemiaapopulationbasedcrosssectionalstudyintaiwanbetween2020and2021 AT shihhaohuang realworldcharacteristicsandtreatmentpatternsinessentialthrombocythemiaapopulationbasedcrosssectionalstudyintaiwanbetween2020and2021 AT tsunghsientsai realworldcharacteristicsandtreatmentpatternsinessentialthrombocythemiaapopulationbasedcrosssectionalstudyintaiwanbetween2020and2021 AT alexjiahonglin realworldcharacteristicsandtreatmentpatternsinessentialthrombocythemiaapopulationbasedcrosssectionalstudyintaiwanbetween2020and2021 AT joseftprchal realworldcharacteristicsandtreatmentpatternsinessentialthrombocythemiaapopulationbasedcrosssectionalstudyintaiwanbetween2020and2021 AT minchichen realworldcharacteristicsandtreatmentpatternsinessentialthrombocythemiaapopulationbasedcrosssectionalstudyintaiwanbetween2020and2021 AT kuanderlee realworldcharacteristicsandtreatmentpatternsinessentialthrombocythemiaapopulationbasedcrosssectionalstudyintaiwanbetween2020and2021 |