Fetuin-A – Alpha2-Heremans-Schmid Glycoprotein: From Structure to a Novel Marker of Chronic Diseases Part 1. Fetuin-A as a Calcium Chaperone and Inflammatory Marker
Fetuin-A is a major plasma glycoprotein released mainly by the liver. Its functions include inhibition of the activity of insulin receptor, regulation of response to inflammation, inhibition of calcified matrix metabolism and ectopic mineralization, etc. Three major functional domains of fetuin-A ha...
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| Format: | Article |
| Language: | English |
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Medical University - Pleven
2018-03-01
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| Series: | Journal of Biomedical & Clinical Research |
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| Online Access: | https://jbcr.arphahub.com/article/34470/download/pdf/ |
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| _version_ | 1850068124968157184 |
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| author | Regina Komsa-Penkova Georgi Golemanov Zdravka Radionova Pencho Tonchev Sergej Iliev Veselin Penkov |
| author_facet | Regina Komsa-Penkova Georgi Golemanov Zdravka Radionova Pencho Tonchev Sergej Iliev Veselin Penkov |
| author_sort | Regina Komsa-Penkova |
| collection | DOAJ |
| description | Fetuin-A is a major plasma glycoprotein released mainly by the liver. Its functions include inhibition of the activity of insulin receptor, regulation of response to inflammation, inhibition of calcified matrix metabolism and ectopic mineralization, etc. Three major functional domains of fetuin-A have been identified: one similar to the Ca-binding domains, one inhibiting cysteine protease, and a domain with high affinity to insulin receptor. The fetuin-A molecule may be considered as a highly pleomorphic protein with an important impact in a variety of clinically expressed metabolic and pathological processes. It could be used as a marker in clinical practice in the future. |
| format | Article |
| id | doaj-art-d11f2eb871944ea2824c7188f40535f1 |
| institution | DOAJ |
| issn | 1313-9053 |
| language | English |
| publishDate | 2018-03-01 |
| publisher | Medical University - Pleven |
| record_format | Article |
| series | Journal of Biomedical & Clinical Research |
| spelling | doaj-art-d11f2eb871944ea2824c7188f40535f12025-08-20T02:48:09ZengMedical University - PlevenJournal of Biomedical & Clinical Research1313-90532018-03-01102909710.1515/jbcr-2017-001534470Fetuin-A – Alpha2-Heremans-Schmid Glycoprotein: From Structure to a Novel Marker of Chronic Diseases Part 1. Fetuin-A as a Calcium Chaperone and Inflammatory MarkerRegina Komsa-PenkovaGeorgi GolemanovZdravka RadionovaPencho TonchevSergej IlievVeselin PenkovFetuin-A is a major plasma glycoprotein released mainly by the liver. Its functions include inhibition of the activity of insulin receptor, regulation of response to inflammation, inhibition of calcified matrix metabolism and ectopic mineralization, etc. Three major functional domains of fetuin-A have been identified: one similar to the Ca-binding domains, one inhibiting cysteine protease, and a domain with high affinity to insulin receptor. The fetuin-A molecule may be considered as a highly pleomorphic protein with an important impact in a variety of clinically expressed metabolic and pathological processes. It could be used as a marker in clinical practice in the future.https://jbcr.arphahub.com/article/34470/download/pdf/fetuin-Ainflammationcystatincalcium chaperon |
| spellingShingle | Regina Komsa-Penkova Georgi Golemanov Zdravka Radionova Pencho Tonchev Sergej Iliev Veselin Penkov Fetuin-A – Alpha2-Heremans-Schmid Glycoprotein: From Structure to a Novel Marker of Chronic Diseases Part 1. Fetuin-A as a Calcium Chaperone and Inflammatory Marker Journal of Biomedical & Clinical Research fetuin-A inflammation cystatin calcium chaperon |
| title | Fetuin-A – Alpha2-Heremans-Schmid Glycoprotein: From Structure to a Novel Marker of Chronic Diseases Part 1. Fetuin-A as a Calcium Chaperone and Inflammatory Marker |
| title_full | Fetuin-A – Alpha2-Heremans-Schmid Glycoprotein: From Structure to a Novel Marker of Chronic Diseases Part 1. Fetuin-A as a Calcium Chaperone and Inflammatory Marker |
| title_fullStr | Fetuin-A – Alpha2-Heremans-Schmid Glycoprotein: From Structure to a Novel Marker of Chronic Diseases Part 1. Fetuin-A as a Calcium Chaperone and Inflammatory Marker |
| title_full_unstemmed | Fetuin-A – Alpha2-Heremans-Schmid Glycoprotein: From Structure to a Novel Marker of Chronic Diseases Part 1. Fetuin-A as a Calcium Chaperone and Inflammatory Marker |
| title_short | Fetuin-A – Alpha2-Heremans-Schmid Glycoprotein: From Structure to a Novel Marker of Chronic Diseases Part 1. Fetuin-A as a Calcium Chaperone and Inflammatory Marker |
| title_sort | fetuin a alpha2 heremans schmid glycoprotein from structure to a novel marker of chronic diseases part 1 fetuin a as a calcium chaperone and inflammatory marker |
| topic | fetuin-A inflammation cystatin calcium chaperon |
| url | https://jbcr.arphahub.com/article/34470/download/pdf/ |
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