The hypothesis of non-African origin of human immunodeficiency virus type 1
Longitudinal co-evolution of human beings and pathogens resulted in polymorphism of Homo sapiens. CCR5Δ32 HIV-resistance allele is the exception to the rules. Recent origin of HIV-1 in Africa contradicted with the appearance of CCR5Δ32 allele in Northern Europe in previous ages.The author proposed n...
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| Format: | Article |
| Language: | Russian |
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Journal Infectology
2014-09-01
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| Series: | Журнал инфектологии |
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| Online Access: | https://journal.niidi.ru/jofin/article/view/139 |
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| author | V. P. Sergiev |
| author_facet | V. P. Sergiev |
| author_sort | V. P. Sergiev |
| collection | DOAJ |
| description | Longitudinal co-evolution of human beings and pathogens resulted in polymorphism of Homo sapiens. CCR5Δ32 HIV-resistance allele is the exception to the rules. Recent origin of HIV-1 in Africa contradicted with the appearance of CCR5Δ32 allele in Northern Europe in previous ages.The author proposed non-contradictory theory of primary appearance of ancient HIV-1 in the Northern Europe 5-7 thousand years ago. The primary epidemics of HIV-infection had been stopped by the appearance of CCR5Δ32 mutation among the affected population. Re-emergence of HIV-1 nowadays resulted by the penetration of hibernated HIV-1 into population of drug addicts and homosexual men. |
| format | Article |
| id | doaj-art-d11cd7032f7946f59976c74cbdc8d48b |
| institution | DOAJ |
| issn | 2072-6732 |
| language | Russian |
| publishDate | 2014-09-01 |
| publisher | Journal Infectology |
| record_format | Article |
| series | Журнал инфектологии |
| spelling | doaj-art-d11cd7032f7946f59976c74cbdc8d48b2025-08-20T03:22:15ZrusJournal InfectologyЖурнал инфектологии2072-67322014-09-01449710410.22625/2072-6732-2012-4-4-97-104153The hypothesis of non-African origin of human immunodeficiency virus type 1V. P. Sergiev0Moscow State Medical University named after I.M. Sechenov, MoscowLongitudinal co-evolution of human beings and pathogens resulted in polymorphism of Homo sapiens. CCR5Δ32 HIV-resistance allele is the exception to the rules. Recent origin of HIV-1 in Africa contradicted with the appearance of CCR5Δ32 allele in Northern Europe in previous ages.The author proposed non-contradictory theory of primary appearance of ancient HIV-1 in the Northern Europe 5-7 thousand years ago. The primary epidemics of HIV-infection had been stopped by the appearance of CCR5Δ32 mutation among the affected population. Re-emergence of HIV-1 nowadays resulted by the penetration of hibernated HIV-1 into population of drug addicts and homosexual men.https://journal.niidi.ru/jofin/article/view/139human immunodeficiency virusorigin of hiv-1ccr5δ32 allele |
| spellingShingle | V. P. Sergiev The hypothesis of non-African origin of human immunodeficiency virus type 1 Журнал инфектологии human immunodeficiency virus origin of hiv-1 ccr5δ32 allele |
| title | The hypothesis of non-African origin of human immunodeficiency virus type 1 |
| title_full | The hypothesis of non-African origin of human immunodeficiency virus type 1 |
| title_fullStr | The hypothesis of non-African origin of human immunodeficiency virus type 1 |
| title_full_unstemmed | The hypothesis of non-African origin of human immunodeficiency virus type 1 |
| title_short | The hypothesis of non-African origin of human immunodeficiency virus type 1 |
| title_sort | hypothesis of non african origin of human immunodeficiency virus type 1 |
| topic | human immunodeficiency virus origin of hiv-1 ccr5δ32 allele |
| url | https://journal.niidi.ru/jofin/article/view/139 |
| work_keys_str_mv | AT vpsergiev thehypothesisofnonafricanoriginofhumanimmunodeficiencyvirustype1 AT vpsergiev hypothesisofnonafricanoriginofhumanimmunodeficiencyvirustype1 |