Comparison of acupuncture and other drugs for chronic constipation: A network meta-analysis.
The objective of this study was to compare the efficacy and side effects of acupuncture, sham acupuncture and drugs in the treatment of chronic constipation. Randomized controlled trials (RCTs) assessing the effects of acupuncture and drugs for chronic constipation were comprehensively retrieved fro...
Saved in:
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2018-01-01
|
| Series: | PLoS ONE |
| Online Access: | https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0196128&type=printable |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850203269801967616 |
|---|---|
| author | Lingping Zhu Yunhui Ma Xiaoyan Deng |
| author_facet | Lingping Zhu Yunhui Ma Xiaoyan Deng |
| author_sort | Lingping Zhu |
| collection | DOAJ |
| description | The objective of this study was to compare the efficacy and side effects of acupuncture, sham acupuncture and drugs in the treatment of chronic constipation. Randomized controlled trials (RCTs) assessing the effects of acupuncture and drugs for chronic constipation were comprehensively retrieved from electronic databases (such as PubMed, Cochrane Library, Embase, CNKI, Wanfang Database, VIP Database and CBM) up to December 2017. Additional references were obtained from review articles. With quality evaluations and data extraction, a network meta-analysis (NMA) was performed using a random-effects model under a frequentist framework. A total of 40 studies (n = 11032) were included: 39 were high-quality studies and 1 was a low-quality study. NMA showed that (1) acupuncture improved the symptoms of chronic constipation more effectively than drugs; (2) the ranking of treatments in terms of efficacy in diarrhoea-predominant irritable bowel syndrome was acupuncture, polyethylene glycol, lactulose, linaclotide, lubiprostone, bisacodyl, prucalopride, sham acupuncture, tegaserod, and placebo; (3) the ranking of side effects were as follows: lactulose, lubiprostone, bisacodyl, polyethylene glycol, prucalopride, linaclotide, placebo and tegaserod; and (4) the most commonly used acupuncture point for chronic constipation was ST25. Acupuncture is more effective than drugs in improving chronic constipation and has the least side effects. In the future, large-scale randomized controlled trials are needed to prove this. Sham acupuncture may have curative effects that are greater than the placebo effect. In the future, it is necessary to perform high-quality studies to support this finding. Polyethylene glycol also has acceptable curative effects with fewer side effects than other drugs. |
| format | Article |
| id | doaj-art-d11aeb710b204bb79604d11e8a916d2d |
| institution | OA Journals |
| issn | 1932-6203 |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj-art-d11aeb710b204bb79604d11e8a916d2d2025-08-20T02:11:34ZengPublic Library of Science (PLoS)PLoS ONE1932-62032018-01-01134e019612810.1371/journal.pone.0196128Comparison of acupuncture and other drugs for chronic constipation: A network meta-analysis.Lingping ZhuYunhui MaXiaoyan DengThe objective of this study was to compare the efficacy and side effects of acupuncture, sham acupuncture and drugs in the treatment of chronic constipation. Randomized controlled trials (RCTs) assessing the effects of acupuncture and drugs for chronic constipation were comprehensively retrieved from electronic databases (such as PubMed, Cochrane Library, Embase, CNKI, Wanfang Database, VIP Database and CBM) up to December 2017. Additional references were obtained from review articles. With quality evaluations and data extraction, a network meta-analysis (NMA) was performed using a random-effects model under a frequentist framework. A total of 40 studies (n = 11032) were included: 39 were high-quality studies and 1 was a low-quality study. NMA showed that (1) acupuncture improved the symptoms of chronic constipation more effectively than drugs; (2) the ranking of treatments in terms of efficacy in diarrhoea-predominant irritable bowel syndrome was acupuncture, polyethylene glycol, lactulose, linaclotide, lubiprostone, bisacodyl, prucalopride, sham acupuncture, tegaserod, and placebo; (3) the ranking of side effects were as follows: lactulose, lubiprostone, bisacodyl, polyethylene glycol, prucalopride, linaclotide, placebo and tegaserod; and (4) the most commonly used acupuncture point for chronic constipation was ST25. Acupuncture is more effective than drugs in improving chronic constipation and has the least side effects. In the future, large-scale randomized controlled trials are needed to prove this. Sham acupuncture may have curative effects that are greater than the placebo effect. In the future, it is necessary to perform high-quality studies to support this finding. Polyethylene glycol also has acceptable curative effects with fewer side effects than other drugs.https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0196128&type=printable |
| spellingShingle | Lingping Zhu Yunhui Ma Xiaoyan Deng Comparison of acupuncture and other drugs for chronic constipation: A network meta-analysis. PLoS ONE |
| title | Comparison of acupuncture and other drugs for chronic constipation: A network meta-analysis. |
| title_full | Comparison of acupuncture and other drugs for chronic constipation: A network meta-analysis. |
| title_fullStr | Comparison of acupuncture and other drugs for chronic constipation: A network meta-analysis. |
| title_full_unstemmed | Comparison of acupuncture and other drugs for chronic constipation: A network meta-analysis. |
| title_short | Comparison of acupuncture and other drugs for chronic constipation: A network meta-analysis. |
| title_sort | comparison of acupuncture and other drugs for chronic constipation a network meta analysis |
| url | https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0196128&type=printable |
| work_keys_str_mv | AT lingpingzhu comparisonofacupunctureandotherdrugsforchronicconstipationanetworkmetaanalysis AT yunhuima comparisonofacupunctureandotherdrugsforchronicconstipationanetworkmetaanalysis AT xiaoyandeng comparisonofacupunctureandotherdrugsforchronicconstipationanetworkmetaanalysis |