Dual implication of endothelial adhesion molecules in tumor progression and cancer immunity
Adhesion molecules are proteins expressed at the surface of various cell types. Their main contribution to immunity is to allow the infiltration of immune cells in an inflamed site. In cancer, adhesion molecules have been shown to promote tumor dissemination favoring the development of metastasis. W...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2025-12-01
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| Series: | Cell Adhesion & Migration |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/19336918.2025.2472308 |
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| _version_ | 1849325768386019328 |
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| author | Louis-Emmanuel Chriqui Sabrina Cavin Jean Yannis Perentes |
| author_facet | Louis-Emmanuel Chriqui Sabrina Cavin Jean Yannis Perentes |
| author_sort | Louis-Emmanuel Chriqui |
| collection | DOAJ |
| description | Adhesion molecules are proteins expressed at the surface of various cell types. Their main contribution to immunity is to allow the infiltration of immune cells in an inflamed site. In cancer, adhesion molecules have been shown to promote tumor dissemination favoring the development of metastasis. While adhesion molecule inhibition approaches were unsuccessful for cancer control, their importance for the generation of an immune response alone or in combination with immunotherapies has gained interest over the past years. Currently, the balance of adhesion molecules for tumor promotion/inhibition is unclear. Here we review the role of selectins, intercellular adhesion molecules (ICAM) and vascular cell adhesion molecules (VCAM) from the perspective of the dual contribution of adhesion molecules in tumor progression and immunity. |
| format | Article |
| id | doaj-art-d11557bc12984bc9b482d8dbb983dc66 |
| institution | Kabale University |
| issn | 1933-6918 1933-6926 |
| language | English |
| publishDate | 2025-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Cell Adhesion & Migration |
| spelling | doaj-art-d11557bc12984bc9b482d8dbb983dc662025-08-20T03:48:19ZengTaylor & Francis GroupCell Adhesion & Migration1933-69181933-69262025-12-0119110.1080/19336918.2025.2472308Dual implication of endothelial adhesion molecules in tumor progression and cancer immunityLouis-Emmanuel Chriqui0Sabrina Cavin1Jean Yannis Perentes2Division of Thoracic Surgery, Department of Surgery, CHUV, Lausanne University Hospital, Lausanne, SwitzerlandDivision of Thoracic Surgery, Department of Surgery, CHUV, Lausanne University Hospital, Lausanne, SwitzerlandDivision of Thoracic Surgery, Department of Surgery, CHUV, Lausanne University Hospital, Lausanne, SwitzerlandAdhesion molecules are proteins expressed at the surface of various cell types. Their main contribution to immunity is to allow the infiltration of immune cells in an inflamed site. In cancer, adhesion molecules have been shown to promote tumor dissemination favoring the development of metastasis. While adhesion molecule inhibition approaches were unsuccessful for cancer control, their importance for the generation of an immune response alone or in combination with immunotherapies has gained interest over the past years. Currently, the balance of adhesion molecules for tumor promotion/inhibition is unclear. Here we review the role of selectins, intercellular adhesion molecules (ICAM) and vascular cell adhesion molecules (VCAM) from the perspective of the dual contribution of adhesion molecules in tumor progression and immunity.https://www.tandfonline.com/doi/10.1080/19336918.2025.2472308Adhesion moleculesICAMimmunotherapymetastasisselectinsVCAM |
| spellingShingle | Louis-Emmanuel Chriqui Sabrina Cavin Jean Yannis Perentes Dual implication of endothelial adhesion molecules in tumor progression and cancer immunity Cell Adhesion & Migration Adhesion molecules ICAM immunotherapy metastasis selectins VCAM |
| title | Dual implication of endothelial adhesion molecules in tumor progression and cancer immunity |
| title_full | Dual implication of endothelial adhesion molecules in tumor progression and cancer immunity |
| title_fullStr | Dual implication of endothelial adhesion molecules in tumor progression and cancer immunity |
| title_full_unstemmed | Dual implication of endothelial adhesion molecules in tumor progression and cancer immunity |
| title_short | Dual implication of endothelial adhesion molecules in tumor progression and cancer immunity |
| title_sort | dual implication of endothelial adhesion molecules in tumor progression and cancer immunity |
| topic | Adhesion molecules ICAM immunotherapy metastasis selectins VCAM |
| url | https://www.tandfonline.com/doi/10.1080/19336918.2025.2472308 |
| work_keys_str_mv | AT louisemmanuelchriqui dualimplicationofendothelialadhesionmoleculesintumorprogressionandcancerimmunity AT sabrinacavin dualimplicationofendothelialadhesionmoleculesintumorprogressionandcancerimmunity AT jeanyannisperentes dualimplicationofendothelialadhesionmoleculesintumorprogressionandcancerimmunity |