Parthenogenesis and Human Assisted Reproduction
Parthenogenetic activation of human oocytes obtained from infertility treatments has gained new interest in recent years as an alternative approach to create embryos with no reproductive purpose for research in areas such as assisted reproduction technologies itself, somatic cell, and nuclear transf...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2016-01-01
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| Series: | Stem Cells International |
| Online Access: | http://dx.doi.org/10.1155/2016/1970843 |
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| _version_ | 1832547465582084096 |
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| author | Adriana Bos-Mikich Fabiana F. Bressan Rafael R. Ruggeri Yeda Watanabe Flávio V. Meirelles |
| author_facet | Adriana Bos-Mikich Fabiana F. Bressan Rafael R. Ruggeri Yeda Watanabe Flávio V. Meirelles |
| author_sort | Adriana Bos-Mikich |
| collection | DOAJ |
| description | Parthenogenetic activation of human oocytes obtained from infertility treatments has gained new interest in recent years as an alternative approach to create embryos with no reproductive purpose for research in areas such as assisted reproduction technologies itself, somatic cell, and nuclear transfer experiments and for derivation of clinical grade pluripotent embryonic stem cells for regenerative medicine. Different activating methods have been tested on human and nonhuman oocytes, with varying degrees of success in terms of parthenote generation rates, embryo development stem cell derivation rates. Success in achieving a standardized artificial activation methodology for human oocytes and the subsequent potential therapeutic gain obtained from these embryos depends mainly on the availability of gametes donated from infertility treatments. This review will focus on the creation of parthenotes from clinically unusable oocytes for derivation and establishment of human parthenogenetic stem cell lines and their potential applications in regenerative medicine. |
| format | Article |
| id | doaj-art-d1141d93899e438e842bf15904fc574b |
| institution | Kabale University |
| issn | 1687-966X 1687-9678 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Stem Cells International |
| spelling | doaj-art-d1141d93899e438e842bf15904fc574b2025-02-03T06:44:46ZengWileyStem Cells International1687-966X1687-96782016-01-01201610.1155/2016/19708431970843Parthenogenesis and Human Assisted ReproductionAdriana Bos-Mikich0Fabiana F. Bressan1Rafael R. Ruggeri2Yeda Watanabe3Flávio V. Meirelles4Department of Morphological Sciences, ICBS, Federal University of Rio Grande do Sul, 90050-170 Porto Alegre, RS, BrazilDepartment of Veterinary Medicine, Faculty of Animal, Science and Food Engineering (FZEA), University of São Paulo (USP), 13635-000 Pirassununga, SP, BrazilDepartment of Morphological Sciences, ICBS, Federal University of Rio Grande do Sul, 90050-170 Porto Alegre, RS, BrazilWTA Fertilização In Vitro Ltda, 14140-000 Cravinhos, SP, BrazilDepartment of Veterinary Medicine, Faculty of Animal, Science and Food Engineering (FZEA), University of São Paulo (USP), 13635-000 Pirassununga, SP, BrazilParthenogenetic activation of human oocytes obtained from infertility treatments has gained new interest in recent years as an alternative approach to create embryos with no reproductive purpose for research in areas such as assisted reproduction technologies itself, somatic cell, and nuclear transfer experiments and for derivation of clinical grade pluripotent embryonic stem cells for regenerative medicine. Different activating methods have been tested on human and nonhuman oocytes, with varying degrees of success in terms of parthenote generation rates, embryo development stem cell derivation rates. Success in achieving a standardized artificial activation methodology for human oocytes and the subsequent potential therapeutic gain obtained from these embryos depends mainly on the availability of gametes donated from infertility treatments. This review will focus on the creation of parthenotes from clinically unusable oocytes for derivation and establishment of human parthenogenetic stem cell lines and their potential applications in regenerative medicine.http://dx.doi.org/10.1155/2016/1970843 |
| spellingShingle | Adriana Bos-Mikich Fabiana F. Bressan Rafael R. Ruggeri Yeda Watanabe Flávio V. Meirelles Parthenogenesis and Human Assisted Reproduction Stem Cells International |
| title | Parthenogenesis and Human Assisted Reproduction |
| title_full | Parthenogenesis and Human Assisted Reproduction |
| title_fullStr | Parthenogenesis and Human Assisted Reproduction |
| title_full_unstemmed | Parthenogenesis and Human Assisted Reproduction |
| title_short | Parthenogenesis and Human Assisted Reproduction |
| title_sort | parthenogenesis and human assisted reproduction |
| url | http://dx.doi.org/10.1155/2016/1970843 |
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