Arrhythmogenic mitral valve prolapse—a systematic review of ventricular arrhythmia and sudden cardiac death outcomes before and after mitral valve surgery
Abstract Background Several autopsy and observational studies have investigated the link between mitral valve prolapse (MVP) and sudden cardiac death (SCD) given the well accepted yet rare occurrence of ventricular arrhythmias (VA). Whether surgical intervention for arrhythmogenic MVP (aMVP) reduces...
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| Language: | English |
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Wiley
2025-08-01
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| Series: | Journal of Arrhythmia |
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| Online Access: | https://doi.org/10.1002/joa3.70108 |
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| author | James N. Cameron Nigel Sutherland Chee Loong Chow Hui‐Chen Han Matias Yudi Rajiv Mahajan Anand Ganesan Avi Sabbag Kristina H. Haugaa Jai Raman Prashanthan Sanders Omar Farouque Han S. Lim |
| author_facet | James N. Cameron Nigel Sutherland Chee Loong Chow Hui‐Chen Han Matias Yudi Rajiv Mahajan Anand Ganesan Avi Sabbag Kristina H. Haugaa Jai Raman Prashanthan Sanders Omar Farouque Han S. Lim |
| author_sort | James N. Cameron |
| collection | DOAJ |
| description | Abstract Background Several autopsy and observational studies have investigated the link between mitral valve prolapse (MVP) and sudden cardiac death (SCD) given the well accepted yet rare occurrence of ventricular arrhythmias (VA). Whether surgical intervention for arrhythmogenic MVP (aMVP) reduces VA and SCD risk remains unknown. Methods A systematic literature review was conducted using the PubMed database in December 2024. Studies documented in English were included if patients had undergone mitral valve (MV) surgery (MVS; repair or replacement) for MVP with documented rates of VA or SCD pre‐ and postintervention. Results Sixteen identified studies (8 cohort and 8 case studies) comprised 1233 patients (receiving medical or surgical treatment) with a pooled mean age of 61.5 years and 41.9% being female. A total of 657 MVP patients underwent MVS. Seven cohort studies reported rates of VA pre‐ and postintervention, with six of these and all case studies reporting a significant reduction. The remaining cohort study reported a reduction in SCD. Conclusions This systematic review indicates a reduction in VA following current guideline‐directed MVS for MVP. However, a residual risk of VA and SCD may remain postintervention. |
| format | Article |
| id | doaj-art-d1119f5b87534a9888d378cdeb5437e0 |
| institution | Kabale University |
| issn | 1880-4276 1883-2148 |
| language | English |
| publishDate | 2025-08-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Arrhythmia |
| spelling | doaj-art-d1119f5b87534a9888d378cdeb5437e02025-08-26T10:38:54ZengWileyJournal of Arrhythmia1880-42761883-21482025-08-01414n/an/a10.1002/joa3.70108Arrhythmogenic mitral valve prolapse—a systematic review of ventricular arrhythmia and sudden cardiac death outcomes before and after mitral valve surgeryJames N. Cameron0Nigel Sutherland1Chee Loong Chow2Hui‐Chen Han3Matias Yudi4Rajiv Mahajan5Anand Ganesan6Avi Sabbag7Kristina H. Haugaa8Jai Raman9Prashanthan Sanders10Omar Farouque11Han S. Lim12Department of Cardiology Austin Health Melbourne Victoria AustraliaDepartment of Cardiology Northern Health Melbourne Victoria AustraliaFaculty of Medicine, Dentistry and Health Sciences University of Melbourne Melbourne Victoria AustraliaVictorian Heart Institute Monash University Clayton Victoria AustraliaDepartment of Cardiology Austin Health Melbourne Victoria AustraliaAdelaide Medical School University of Adelaide Adelaide South Australia AustraliaDepartment of Cardiovascular Medicine Flinders Medical Centre Adelaide South Australia AustraliaThe Davidai Center for Rhythm Disturbances and Pacing, Chaim Sheba Medical Center Tel Hashomer IsraelProCardio Center for Cardiological Innovation, Department of Cardiology Oslo University Hospital, Rikshospitalet Oslo NorwayDepartment of Cardiac Surgery Austin Health Melbourne Victoria AustraliaCentre for Heart Rhythm Disorders, South Australian Health and Medical Research Institute University of Adelaide and Royal Adelaide Hospital Adelaide South Australia AustraliaDepartment of Cardiology Austin Health Melbourne Victoria AustraliaDepartment of Cardiology Austin Health Melbourne Victoria AustraliaAbstract Background Several autopsy and observational studies have investigated the link between mitral valve prolapse (MVP) and sudden cardiac death (SCD) given the well accepted yet rare occurrence of ventricular arrhythmias (VA). Whether surgical intervention for arrhythmogenic MVP (aMVP) reduces VA and SCD risk remains unknown. Methods A systematic literature review was conducted using the PubMed database in December 2024. Studies documented in English were included if patients had undergone mitral valve (MV) surgery (MVS; repair or replacement) for MVP with documented rates of VA or SCD pre‐ and postintervention. Results Sixteen identified studies (8 cohort and 8 case studies) comprised 1233 patients (receiving medical or surgical treatment) with a pooled mean age of 61.5 years and 41.9% being female. A total of 657 MVP patients underwent MVS. Seven cohort studies reported rates of VA pre‐ and postintervention, with six of these and all case studies reporting a significant reduction. The remaining cohort study reported a reduction in SCD. Conclusions This systematic review indicates a reduction in VA following current guideline‐directed MVS for MVP. However, a residual risk of VA and SCD may remain postintervention.https://doi.org/10.1002/joa3.70108mitral valve prolapsemitral valve surgerypercutaneous mitral valve repairsudden cardiac deathventricular arrhythmia |
| spellingShingle | James N. Cameron Nigel Sutherland Chee Loong Chow Hui‐Chen Han Matias Yudi Rajiv Mahajan Anand Ganesan Avi Sabbag Kristina H. Haugaa Jai Raman Prashanthan Sanders Omar Farouque Han S. Lim Arrhythmogenic mitral valve prolapse—a systematic review of ventricular arrhythmia and sudden cardiac death outcomes before and after mitral valve surgery Journal of Arrhythmia mitral valve prolapse mitral valve surgery percutaneous mitral valve repair sudden cardiac death ventricular arrhythmia |
| title | Arrhythmogenic mitral valve prolapse—a systematic review of ventricular arrhythmia and sudden cardiac death outcomes before and after mitral valve surgery |
| title_full | Arrhythmogenic mitral valve prolapse—a systematic review of ventricular arrhythmia and sudden cardiac death outcomes before and after mitral valve surgery |
| title_fullStr | Arrhythmogenic mitral valve prolapse—a systematic review of ventricular arrhythmia and sudden cardiac death outcomes before and after mitral valve surgery |
| title_full_unstemmed | Arrhythmogenic mitral valve prolapse—a systematic review of ventricular arrhythmia and sudden cardiac death outcomes before and after mitral valve surgery |
| title_short | Arrhythmogenic mitral valve prolapse—a systematic review of ventricular arrhythmia and sudden cardiac death outcomes before and after mitral valve surgery |
| title_sort | arrhythmogenic mitral valve prolapse a systematic review of ventricular arrhythmia and sudden cardiac death outcomes before and after mitral valve surgery |
| topic | mitral valve prolapse mitral valve surgery percutaneous mitral valve repair sudden cardiac death ventricular arrhythmia |
| url | https://doi.org/10.1002/joa3.70108 |
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