From Bench to Clinic: Crosslinking Approaches for Next-Generation Collagen Fillers

With a deeper understanding of the aging process, injectable dermal fillers have revolutionized cosmetic dermatology and plastic surgery. These minimally invasive treatments address signs of aging, such as wrinkles, fine lines, and volume loss. The market for injectable dermal fillers expands yearly...

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Main Authors: Song-Yi Wu, Chen-Chi Tsai, Wei-Bor Tsai
Format: Article
Language:English
Published: Wiley 2025-01-01
Series:Advances in Polymer Technology
Online Access:http://dx.doi.org/10.1155/adv/3899983
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author Song-Yi Wu
Chen-Chi Tsai
Wei-Bor Tsai
author_facet Song-Yi Wu
Chen-Chi Tsai
Wei-Bor Tsai
author_sort Song-Yi Wu
collection DOAJ
description With a deeper understanding of the aging process, injectable dermal fillers have revolutionized cosmetic dermatology and plastic surgery. These minimally invasive treatments address signs of aging, such as wrinkles, fine lines, and volume loss. The market for injectable dermal fillers expands yearly, with each product offering unique compositions that influence therapeutic outcomes, handling properties, and potential adverse effects. Fillers are generally classified into three major types: temporary, semi-permanent, and permanent. Temporary fillers, including hyaluronic acid (HA) and collagen (COL)-based options, provide reliable correction but typically have limited longevity. Semi-permanent and permanent fillers, made from synthetic materials like poly-L-lactic acid and polymethylmethacrylate (PMMA), offer extended durations of neocollagenesis. This review focuses specifically on COL-based fillers, discussing both FDA-approved products and those still in the research stage.
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institution Kabale University
issn 1098-2329
language English
publishDate 2025-01-01
publisher Wiley
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series Advances in Polymer Technology
spelling doaj-art-d104a4a322e14497b9045324b999dd432025-02-08T00:00:05ZengWileyAdvances in Polymer Technology1098-23292025-01-01202510.1155/adv/3899983From Bench to Clinic: Crosslinking Approaches for Next-Generation Collagen FillersSong-Yi Wu0Chen-Chi Tsai1Wei-Bor Tsai2Department of Chemical Engineering and Program of Green Materials and Precision DevicesGuangdong Victory Biotech Co., Ltd.Department of Chemical Engineering and Program of Green Materials and Precision DevicesWith a deeper understanding of the aging process, injectable dermal fillers have revolutionized cosmetic dermatology and plastic surgery. These minimally invasive treatments address signs of aging, such as wrinkles, fine lines, and volume loss. The market for injectable dermal fillers expands yearly, with each product offering unique compositions that influence therapeutic outcomes, handling properties, and potential adverse effects. Fillers are generally classified into three major types: temporary, semi-permanent, and permanent. Temporary fillers, including hyaluronic acid (HA) and collagen (COL)-based options, provide reliable correction but typically have limited longevity. Semi-permanent and permanent fillers, made from synthetic materials like poly-L-lactic acid and polymethylmethacrylate (PMMA), offer extended durations of neocollagenesis. This review focuses specifically on COL-based fillers, discussing both FDA-approved products and those still in the research stage.http://dx.doi.org/10.1155/adv/3899983
spellingShingle Song-Yi Wu
Chen-Chi Tsai
Wei-Bor Tsai
From Bench to Clinic: Crosslinking Approaches for Next-Generation Collagen Fillers
Advances in Polymer Technology
title From Bench to Clinic: Crosslinking Approaches for Next-Generation Collagen Fillers
title_full From Bench to Clinic: Crosslinking Approaches for Next-Generation Collagen Fillers
title_fullStr From Bench to Clinic: Crosslinking Approaches for Next-Generation Collagen Fillers
title_full_unstemmed From Bench to Clinic: Crosslinking Approaches for Next-Generation Collagen Fillers
title_short From Bench to Clinic: Crosslinking Approaches for Next-Generation Collagen Fillers
title_sort from bench to clinic crosslinking approaches for next generation collagen fillers
url http://dx.doi.org/10.1155/adv/3899983
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