Restoring mucosal barrier homeostasis by in situ formation of a living-synthetic therapeutic coating
Abstract The mucosal barrier consisting of physicochemical, immune, and microbial components is the first line of defense against external stimuli. Breakdown of the mucosal barrier causes the occurrences of various diseases, while methods capable of multifacetedly restoring mucosal barrier functions...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2025-08-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-025-63110-0 |
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| author | Wei Yu Huilong Luo Bo Han Sisi Lin Qian Li Rui Xue Hui Tang Xin Jia Lu Wang Jinyao Liu |
| author_facet | Wei Yu Huilong Luo Bo Han Sisi Lin Qian Li Rui Xue Hui Tang Xin Jia Lu Wang Jinyao Liu |
| author_sort | Wei Yu |
| collection | DOAJ |
| description | Abstract The mucosal barrier consisting of physicochemical, immune, and microbial components is the first line of defense against external stimuli. Breakdown of the mucosal barrier causes the occurrences of various diseases, while methods capable of multifacetedly restoring mucosal barrier functions have been rarely reported. Here, we describe the restoration of the physicochemical, immune, and microbial homeostasis of the mucosal barrier by in situ formation of a living-synthetic therapeutic coating (LSTC). Through metal-phenolic complexation and π-π stacking interactions, ethyl gallate can chelate BiIII ions to form an adhesive coating on mucosal surfaces, which enables further hybridization with living bacteria. Due to the beneficial effects of BiIII and ethyl gallate and the probiotic characteristic of carried bacteria, LSTC increases the barrier integrity, mitigates mucosal inflammation, and maintains normal homoeostasis of the microbiota. In two murine models of aerobic vaginitis and vaginal candidiasis, LSTC demonstrates the potency to alleviate vaginal pathological injury and decrease vaginal inflammatory infiltration. |
| format | Article |
| id | doaj-art-d103a0953535499e9b1cced1d694d8d7 |
| institution | Kabale University |
| issn | 2041-1723 |
| language | English |
| publishDate | 2025-08-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj-art-d103a0953535499e9b1cced1d694d8d72025-08-24T11:38:08ZengNature PortfolioNature Communications2041-17232025-08-0116111710.1038/s41467-025-63110-0Restoring mucosal barrier homeostasis by in situ formation of a living-synthetic therapeutic coatingWei Yu0Huilong Luo1Bo Han2Sisi Lin3Qian Li4Rui Xue5Hui Tang6Xin Jia7Lu Wang8Jinyao Liu9School of Chemistry and Chemical Engineering, School of Pharmacy, Key Laboratory of Xinjiang Phytomedicine Resource and Utilization, Shihezi UniversityShanghai Key Laboratory for Nucleic Acid Chemistry and Nanomedicine, Institute of Molecular Medicine, Renji Hospital, School of Medicine, Shanghai Jiao Tong UniversitySchool of Chemistry and Chemical Engineering, School of Pharmacy, Key Laboratory of Xinjiang Phytomedicine Resource and Utilization, Shihezi UniversityShanghai Key Laboratory for Nucleic Acid Chemistry and Nanomedicine, Institute of Molecular Medicine, Renji Hospital, School of Medicine, Shanghai Jiao Tong UniversityXinjiang Military Command General HospitalSchool of Chemistry and Chemical Engineering, School of Pharmacy, Key Laboratory of Xinjiang Phytomedicine Resource and Utilization, Shihezi UniversitySchool of Chemistry and Chemical Engineering, School of Pharmacy, Key Laboratory of Xinjiang Phytomedicine Resource and Utilization, Shihezi UniversitySchool of Chemistry and Chemical Engineering, School of Pharmacy, Key Laboratory of Xinjiang Phytomedicine Resource and Utilization, Shihezi UniversityShanghai Key Laboratory for Nucleic Acid Chemistry and Nanomedicine, Institute of Molecular Medicine, Renji Hospital, School of Medicine, Shanghai Jiao Tong UniversityShanghai Key Laboratory for Nucleic Acid Chemistry and Nanomedicine, Institute of Molecular Medicine, Renji Hospital, School of Medicine, Shanghai Jiao Tong UniversityAbstract The mucosal barrier consisting of physicochemical, immune, and microbial components is the first line of defense against external stimuli. Breakdown of the mucosal barrier causes the occurrences of various diseases, while methods capable of multifacetedly restoring mucosal barrier functions have been rarely reported. Here, we describe the restoration of the physicochemical, immune, and microbial homeostasis of the mucosal barrier by in situ formation of a living-synthetic therapeutic coating (LSTC). Through metal-phenolic complexation and π-π stacking interactions, ethyl gallate can chelate BiIII ions to form an adhesive coating on mucosal surfaces, which enables further hybridization with living bacteria. Due to the beneficial effects of BiIII and ethyl gallate and the probiotic characteristic of carried bacteria, LSTC increases the barrier integrity, mitigates mucosal inflammation, and maintains normal homoeostasis of the microbiota. In two murine models of aerobic vaginitis and vaginal candidiasis, LSTC demonstrates the potency to alleviate vaginal pathological injury and decrease vaginal inflammatory infiltration.https://doi.org/10.1038/s41467-025-63110-0 |
| spellingShingle | Wei Yu Huilong Luo Bo Han Sisi Lin Qian Li Rui Xue Hui Tang Xin Jia Lu Wang Jinyao Liu Restoring mucosal barrier homeostasis by in situ formation of a living-synthetic therapeutic coating Nature Communications |
| title | Restoring mucosal barrier homeostasis by in situ formation of a living-synthetic therapeutic coating |
| title_full | Restoring mucosal barrier homeostasis by in situ formation of a living-synthetic therapeutic coating |
| title_fullStr | Restoring mucosal barrier homeostasis by in situ formation of a living-synthetic therapeutic coating |
| title_full_unstemmed | Restoring mucosal barrier homeostasis by in situ formation of a living-synthetic therapeutic coating |
| title_short | Restoring mucosal barrier homeostasis by in situ formation of a living-synthetic therapeutic coating |
| title_sort | restoring mucosal barrier homeostasis by in situ formation of a living synthetic therapeutic coating |
| url | https://doi.org/10.1038/s41467-025-63110-0 |
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