Endoplasmic reticulum stress-induced CRELD2 promotes APMAP-mediated activation of TGF-β/SMAD and NF-κB pathways in esophageal squamous cell carcinoma

Endoplasmic reticulum stress-induced CRELD2 promotes APMAP-mediated activation of TGF-β/SMAD and NF-κB pathways in esophageal squamous cell carcinoma

BackgroundTumor cells experience endoplasmic reticulum (ER) stress due to oncogene activation and stressors in the tumor microenvironment, such as hypoxia and acidosis. ER stress plays a crucial role in carcinogenesis. However, its oncogenic mechanism in esophageal squamous cell carcinoma (ESCC) rem...

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Bibliographic Details
Main Authors: Fangyu Su, Xia Yang, Zhaoyang Yan, Junhong Wu, Xiaoxu Li, Tongxin Xu, Huanchen Xu, Xinhao Wang, Zhaokun Hu, Juntao Lu, Wei Guo
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-07-01
Series:Frontiers in Immunology
Subjects:
esophageal squamous cell carcinoma
endoplasmic reticulum stress
CRELD2
APMAP
TGF-β/SMAD pathway
NF-κB pathway
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1616201/full
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