Recovery of centralities in medial prefrontal and sensory-related cortices associated with social behavior improvements in an autism mouse model

Recovery of centralities in medial prefrontal and sensory-related cortices associated with social behavior improvements in an autism mouse model

Abstract Anti-epileptics and diuretics, used for unapproved purposes, have been reported to ameliorate social deficits in individuals with autism spectrum disorder. However, the underlying neural mechanisms remain unclear. Here, we explored the effects of bumetanide, clonazepam, and phenytoin, all w...

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Main Authors: Hiroki Ueno, Yusuke Iyanaga, Katsuyuki Kunida, Yuta Hara, Hiroki Miura, Yuka Nakai, Masato Tanuma, Misuzu Hayashida, Rei Yokoyama, Jin Ohkubo, Kaoru Seiriki, Atsuko Hayata-Takano, Tomoka Ao, Shun Yamaguchi, Shiho Kitaoka, Tomoyuki Furuyashiki, Yukio Ago, Takanobu Nakazawa, Kazuhiro Takuma, Junichiro Yoshimoto, Hitoshi Hashimoto, Atsushi Kasai
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Scientific Reports
Subjects:
Autism spectrum disorders
Node centrality
Medial prefrontal cortex
Sensorimotor cortex
Brain-wide IEG mapping
Online Access:https://doi.org/10.1038/s41598-025-05996-w
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