Reduced proteasome activity in the aging brain results in ribosome stoichiometry loss and aggregation

Reduced proteasome activity in the aging brain results in ribosome stoichiometry loss and aggregation

Abstract A progressive loss of protein homeostasis is characteristic of aging and a driver of neurodegeneration. To investigate this process quantitatively, we characterized proteome dynamics during brain aging in the short‐lived vertebrate Nothobranchius furzeri combining transcriptomics and proteo...

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Main Authors: Erika Kelmer Sacramento, Joanna M Kirkpatrick, Mariateresa Mazzetto, Mario Baumgart, Aleksandar Bartolome, Simone Di Sanzo, Cinzia Caterino, Michele Sanguanini, Nikoletta Papaevgeniou, Maria Lefaki, Dorothee Childs, Sara Bagnoli, Eva Terzibasi Tozzini, Domenico Di Fraia, Natalie Romanov, Peter H Sudmant, Wolfgang Huber, Niki Chondrogianni, Michele Vendruscolo, Alessandro Cellerino, Alessandro Ori
Format: Article
Language:English
Published: Springer Nature 2020-06-01
Series:Molecular Systems Biology
Subjects:
aging
lifespan
proteome
stoichiometry
transcriptome
Online Access:https://doi.org/10.15252/msb.20209596
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