Modulation of GLP-1 signalling as an innovative strategy counteracting the onset of heart failure: Potential for natural compound supplementation
The clinical continuum of heart failure (HF) is commonly divided into four stages (A, B, C and D), but despite the identification of its staging, to date, the management of the early phases remains an unmet need. In fact, the incomplete knowledge of the molecular mechanisms associated with the comor...
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Elsevier
2025-06-01
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| Series: | Pharmacological Research |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1043661825001690 |
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| author | Micaela Gliozzi Anna Rita Coppoletta Antonio Cardamone Cristina Carresi Rocco Mollace Vincenzo Musolino Vincenzo Mollace |
| author_facet | Micaela Gliozzi Anna Rita Coppoletta Antonio Cardamone Cristina Carresi Rocco Mollace Vincenzo Musolino Vincenzo Mollace |
| author_sort | Micaela Gliozzi |
| collection | DOAJ |
| description | The clinical continuum of heart failure (HF) is commonly divided into four stages (A, B, C and D), but despite the identification of its staging, to date, the management of the early phases remains an unmet need. In fact, the incomplete knowledge of the molecular mechanisms associated with the comorbidities leading to HF onset represents an obstacle to a targeted therapy. Recently, stages A and B have been further typified and, starting from this novel characterization, the aim of our review was to propose an alternative criterion to appropriately use GLP-1 RA in association with plant-derived polyphenolic extracts. This alternative approach is based on the selection of the main molecular mechanisms underlying the early and asymptomatic HF onset that might be further prevented or antagonized through the administration of natural extracts. |
| format | Article |
| id | doaj-art-d0f83bc5efa34bb7b430cb57b9d025d9 |
| institution | OA Journals |
| issn | 1096-1186 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Pharmacological Research |
| spelling | doaj-art-d0f83bc5efa34bb7b430cb57b9d025d92025-08-20T02:32:19ZengElsevierPharmacological Research1096-11862025-06-0121610774410.1016/j.phrs.2025.107744Modulation of GLP-1 signalling as an innovative strategy counteracting the onset of heart failure: Potential for natural compound supplementationMicaela Gliozzi0Anna Rita Coppoletta1Antonio Cardamone2Cristina Carresi3Rocco Mollace4Vincenzo Musolino5Vincenzo Mollace6Pharmacology Laboratory, CIS IRC-FSH, Department of Health Sciences - University Magna Græcia of Catanzaro, Catanzaro 88100, Italy; Corresponding authors.Pharmacology Laboratory, CIS IRC-FSH, Department of Health Sciences - University Magna Græcia of Catanzaro, Catanzaro 88100, ItalyPhysiology Laboratory, CIS IRC-FSH, Department of Health Sciences - University Magna Græcia of Catanzaro, Catanzaro 88100, Italy; Corresponding authors.Veterinary Pharmacology Laboratory, CIS IRC-FSH, Department of Health Sciences - University Magna Græcia of Catanzaro, Catanzaro 88100, ItalyDepartment of Experimental Medicine, Tor Vergata University, Rome 00133, Italy; Cardiology Unit, Humanitas Gavazzeni, Bergamo 24125, ItalyLaboratory of Pharmaceutical Biology, CIS IRC-FSH, Department of Health Sciences - University ''Magna Græcia'' of Catanzaro, Catanzaro 88100, ItalyPharmacology Laboratory, CIS IRC-FSH, Department of Health Sciences - University Magna Græcia of Catanzaro, Catanzaro 88100, ItalyThe clinical continuum of heart failure (HF) is commonly divided into four stages (A, B, C and D), but despite the identification of its staging, to date, the management of the early phases remains an unmet need. In fact, the incomplete knowledge of the molecular mechanisms associated with the comorbidities leading to HF onset represents an obstacle to a targeted therapy. Recently, stages A and B have been further typified and, starting from this novel characterization, the aim of our review was to propose an alternative criterion to appropriately use GLP-1 RA in association with plant-derived polyphenolic extracts. This alternative approach is based on the selection of the main molecular mechanisms underlying the early and asymptomatic HF onset that might be further prevented or antagonized through the administration of natural extracts.http://www.sciencedirect.com/science/article/pii/S1043661825001690GLP-1Heart failureNutraceuticalsNatural compound supplementationGLP-1 receptor agonistsPlant-derived bioactive compounds |
| spellingShingle | Micaela Gliozzi Anna Rita Coppoletta Antonio Cardamone Cristina Carresi Rocco Mollace Vincenzo Musolino Vincenzo Mollace Modulation of GLP-1 signalling as an innovative strategy counteracting the onset of heart failure: Potential for natural compound supplementation Pharmacological Research GLP-1 Heart failure Nutraceuticals Natural compound supplementation GLP-1 receptor agonists Plant-derived bioactive compounds |
| title | Modulation of GLP-1 signalling as an innovative strategy counteracting the onset of heart failure: Potential for natural compound supplementation |
| title_full | Modulation of GLP-1 signalling as an innovative strategy counteracting the onset of heart failure: Potential for natural compound supplementation |
| title_fullStr | Modulation of GLP-1 signalling as an innovative strategy counteracting the onset of heart failure: Potential for natural compound supplementation |
| title_full_unstemmed | Modulation of GLP-1 signalling as an innovative strategy counteracting the onset of heart failure: Potential for natural compound supplementation |
| title_short | Modulation of GLP-1 signalling as an innovative strategy counteracting the onset of heart failure: Potential for natural compound supplementation |
| title_sort | modulation of glp 1 signalling as an innovative strategy counteracting the onset of heart failure potential for natural compound supplementation |
| topic | GLP-1 Heart failure Nutraceuticals Natural compound supplementation GLP-1 receptor agonists Plant-derived bioactive compounds |
| url | http://www.sciencedirect.com/science/article/pii/S1043661825001690 |
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