A CDKN2B-Associated Immune Prognostic Model for Predicting Immune Cell Infiltration and Prognosis in Esophageal Carcinoma
Xiulan Peng,1,* Juping Han,2,* Juan Huang,1,* Longshu Zhou,3,* Xianzhe Chen,4,* Wen Zhou5 1Department of Oncology, The Second Affiliated Hospital of Jianghan University, Wuhan, Hubei, 430000, People’s Republic of China; 2Department of Gastroenterology, The Sec...
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Dove Medical Press
2025-04-01
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| Series: | Clinical and Experimental Gastroenterology |
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| author | Peng X Han J Huang J Zhou L Chen X Zhou W |
| author_facet | Peng X Han J Huang J Zhou L Chen X Zhou W |
| author_sort | Peng X |
| collection | DOAJ |
| description | Xiulan Peng,1,* Juping Han,2,* Juan Huang,1,* Longshu Zhou,3,* Xianzhe Chen,4,* Wen Zhou5 1Department of Oncology, The Second Affiliated Hospital of Jianghan University, Wuhan, Hubei, 430000, People’s Republic of China; 2Department of Gastroenterology, The Second Affiliated Hospital of Jianghan University, Wuhan, Hubei, 430000, People’s Republic of China; 3Department of Cardiothoracic Surgery, Sinopharm Dongfeng General Hospital, Hubei University of Medicine, Shiyan, Hubei, 442008, People’s Republic of China; 4Department of Sixin Street Health Service Centre, The Second Affiliated Hospital of Jianghan University, Wuhan, Hubei, 430000, People’s Republic of China; 5Department of Otolaryngology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, 430022, People’s Republic of China*These authors contributed equally to this workCorrespondence: Xiulan Peng; Juan Huang, The Second Affiliated Hospital of Jianghan University, Xianzheng Road 122#, Wuhan, Hubei, 430000, People’s Republic of China, Email pengxlwh@163.com; huangjuan_82@163.comObjective: Studies have indicated that cyclin dependent protein kinase inhibitor 2B (CDKN2B) deletion is one of the most common changes in esophageal cancer (EC) which affects its progression and prognosis. This study explored the association between CDKN2B deletion, immunophenotype, and the prognosis of EC.Methods: We investigated CDKN2B status and RNA expression, identified differentially expressed immune-associated genes between wild-type CDKN2B (CDKN2BWT) and deleted CDKN2B (CDKN2Bdeletion) in Cancer Genome Atlas (TCGA) EC samples. We also a constructed an immune prognostic model (IPM) based on these genes. Thereafter, the effects of IPM on the immune microenvironment of EC were analyzed. Finally, we established a nomogram by integrating the IPM and other clinical factors.Results: CDKN2B deletion leads to downregulation of the immune response in EC. A total of 136 immune-associated genes were identified based on the CDKN2B deletion status, and three genes with remarkable potential as individual targets were selected for model construction. An IPM was developed and validated, it showed good performance in differentiating patients with a low or high risk of poor prognosis, and its predictive ability was independent of traditional clinical features. High-risk patients with EC had increased T follicular helper cells (Tfh) and M0 macrophages, and lower infiltration levels of resting CD4 memory T cells resting, and naive B cells. The nomogram developed for clinical application showed good predictive performance.Conclusions: Our results suggested that CDKN2B deletion was associated with the survival and immune microenvironment in EC. IPM is not only an effective indicator of the immune response and prognosis, but also suggest potential targets for immunotherapy in patients with EC.Keywords: esophageal carcinoma, cyclin dependent protein kinase inhibitor 2B, immune prognostic model, tumor immunity, prognosis |
| format | Article |
| id | doaj-art-d0f4ec5d44c64d7e8986401d2d7c7b7d |
| institution | DOAJ |
| issn | 1178-7023 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | Dove Medical Press |
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| series | Clinical and Experimental Gastroenterology |
| spelling | doaj-art-d0f4ec5d44c64d7e8986401d2d7c7b7d2025-08-20T02:56:01ZengDove Medical PressClinical and Experimental Gastroenterology1178-70232025-04-01Volume 184154102206A CDKN2B-Associated Immune Prognostic Model for Predicting Immune Cell Infiltration and Prognosis in Esophageal CarcinomaPeng XHan JHuang JZhou LChen XZhou WXiulan Peng,1,* Juping Han,2,* Juan Huang,1,* Longshu Zhou,3,* Xianzhe Chen,4,* Wen Zhou5 1Department of Oncology, The Second Affiliated Hospital of Jianghan University, Wuhan, Hubei, 430000, People’s Republic of China; 2Department of Gastroenterology, The Second Affiliated Hospital of Jianghan University, Wuhan, Hubei, 430000, People’s Republic of China; 3Department of Cardiothoracic Surgery, Sinopharm Dongfeng General Hospital, Hubei University of Medicine, Shiyan, Hubei, 442008, People’s Republic of China; 4Department of Sixin Street Health Service Centre, The Second Affiliated Hospital of Jianghan University, Wuhan, Hubei, 430000, People’s Republic of China; 5Department of Otolaryngology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, 430022, People’s Republic of China*These authors contributed equally to this workCorrespondence: Xiulan Peng; Juan Huang, The Second Affiliated Hospital of Jianghan University, Xianzheng Road 122#, Wuhan, Hubei, 430000, People’s Republic of China, Email pengxlwh@163.com; huangjuan_82@163.comObjective: Studies have indicated that cyclin dependent protein kinase inhibitor 2B (CDKN2B) deletion is one of the most common changes in esophageal cancer (EC) which affects its progression and prognosis. This study explored the association between CDKN2B deletion, immunophenotype, and the prognosis of EC.Methods: We investigated CDKN2B status and RNA expression, identified differentially expressed immune-associated genes between wild-type CDKN2B (CDKN2BWT) and deleted CDKN2B (CDKN2Bdeletion) in Cancer Genome Atlas (TCGA) EC samples. We also a constructed an immune prognostic model (IPM) based on these genes. Thereafter, the effects of IPM on the immune microenvironment of EC were analyzed. Finally, we established a nomogram by integrating the IPM and other clinical factors.Results: CDKN2B deletion leads to downregulation of the immune response in EC. A total of 136 immune-associated genes were identified based on the CDKN2B deletion status, and three genes with remarkable potential as individual targets were selected for model construction. An IPM was developed and validated, it showed good performance in differentiating patients with a low or high risk of poor prognosis, and its predictive ability was independent of traditional clinical features. High-risk patients with EC had increased T follicular helper cells (Tfh) and M0 macrophages, and lower infiltration levels of resting CD4 memory T cells resting, and naive B cells. The nomogram developed for clinical application showed good predictive performance.Conclusions: Our results suggested that CDKN2B deletion was associated with the survival and immune microenvironment in EC. IPM is not only an effective indicator of the immune response and prognosis, but also suggest potential targets for immunotherapy in patients with EC.Keywords: esophageal carcinoma, cyclin dependent protein kinase inhibitor 2B, immune prognostic model, tumor immunity, prognosishttps://www.dovepress.com/a-cdkn2b-associated-immune-prognostic-model-for-predicting-immune-cell-peer-reviewed-fulltext-article-CEGesophageal carcinomacyclin dependent protein kinase inhibitor 2bimmune prognostic modeltumor immunityprognosis |
| spellingShingle | Peng X Han J Huang J Zhou L Chen X Zhou W A CDKN2B-Associated Immune Prognostic Model for Predicting Immune Cell Infiltration and Prognosis in Esophageal Carcinoma Clinical and Experimental Gastroenterology esophageal carcinoma cyclin dependent protein kinase inhibitor 2b immune prognostic model tumor immunity prognosis |
| title | A CDKN2B-Associated Immune Prognostic Model for Predicting Immune Cell Infiltration and Prognosis in Esophageal Carcinoma |
| title_full | A CDKN2B-Associated Immune Prognostic Model for Predicting Immune Cell Infiltration and Prognosis in Esophageal Carcinoma |
| title_fullStr | A CDKN2B-Associated Immune Prognostic Model for Predicting Immune Cell Infiltration and Prognosis in Esophageal Carcinoma |
| title_full_unstemmed | A CDKN2B-Associated Immune Prognostic Model for Predicting Immune Cell Infiltration and Prognosis in Esophageal Carcinoma |
| title_short | A CDKN2B-Associated Immune Prognostic Model for Predicting Immune Cell Infiltration and Prognosis in Esophageal Carcinoma |
| title_sort | cdkn2b associated immune prognostic model for predicting immune cell infiltration and prognosis in esophageal carcinoma |
| topic | esophageal carcinoma cyclin dependent protein kinase inhibitor 2b immune prognostic model tumor immunity prognosis |
| url | https://www.dovepress.com/a-cdkn2b-associated-immune-prognostic-model-for-predicting-immune-cell-peer-reviewed-fulltext-article-CEG |
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