Cytokine gene regulation by PGE2, LTB4 and PAF
The initial response of the host to noxious stimuli produces a nonspecific inflammatory response. A more specific immune response is believed to be modulated by two classes of molecules: lipid mediators (PG, LT and PAF) and cytokines, synthesized by phagocytes and parenchyreal cells. In this review...
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| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Wiley
1992-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/S0962935192000024 |
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| _version_ | 1832568247690461184 |
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| author | M. Rola-Pleszczynski J. Stankova |
| author_facet | M. Rola-Pleszczynski J. Stankova |
| author_sort | M. Rola-Pleszczynski |
| collection | DOAJ |
| description | The initial response of the host to noxious stimuli produces a nonspecific inflammatory response. A more specific immune response is believed to be modulated by two classes of molecules: lipid mediators (PG, LT and PAF) and cytokines, synthesized by phagocytes and parenchyreal cells. In this review we discuss the increasing evidence of the interrelationship between eicosanoids, PAF and cytokines: IL-1 and TNF induce PG synthesis in various cells and PG, in turn, modulate cytokine production. We focused on the regulatory effects of LTB4, PGE2 and PAF on cytokine gene expression. |
| format | Article |
| id | doaj-art-d0f2811f647b41e0bf5522c56454b608 |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 1992-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-d0f2811f647b41e0bf5522c56454b6082025-02-03T00:59:28ZengWileyMediators of Inflammation0962-93511466-18611992-01-01115810.1155/S0962935192000024Cytokine gene regulation by PGE2, LTB4 and PAFM. Rola-Pleszczynski0J. Stankova1Immunology Division, Department of Pediatrics, Faculty of Medicine, University of Sherbrooke, Sherbrooke, QC, J1H 5N4, CanadaImmunology Division, Department of Pediatrics, Faculty of Medicine, University of Sherbrooke, Sherbrooke, QC, J1H 5N4, CanadaThe initial response of the host to noxious stimuli produces a nonspecific inflammatory response. A more specific immune response is believed to be modulated by two classes of molecules: lipid mediators (PG, LT and PAF) and cytokines, synthesized by phagocytes and parenchyreal cells. In this review we discuss the increasing evidence of the interrelationship between eicosanoids, PAF and cytokines: IL-1 and TNF induce PG synthesis in various cells and PG, in turn, modulate cytokine production. We focused on the regulatory effects of LTB4, PGE2 and PAF on cytokine gene expression.http://dx.doi.org/10.1155/S0962935192000024 |
| spellingShingle | M. Rola-Pleszczynski J. Stankova Cytokine gene regulation by PGE2, LTB4 and PAF Mediators of Inflammation |
| title | Cytokine gene regulation by PGE2, LTB4 and PAF |
| title_full | Cytokine gene regulation by PGE2, LTB4 and PAF |
| title_fullStr | Cytokine gene regulation by PGE2, LTB4 and PAF |
| title_full_unstemmed | Cytokine gene regulation by PGE2, LTB4 and PAF |
| title_short | Cytokine gene regulation by PGE2, LTB4 and PAF |
| title_sort | cytokine gene regulation by pge2 ltb4 and paf |
| url | http://dx.doi.org/10.1155/S0962935192000024 |
| work_keys_str_mv | AT mrolapleszczynski cytokinegeneregulationbypge2ltb4andpaf AT jstankova cytokinegeneregulationbypge2ltb4andpaf |