Characteristics of lower respiratory tract pathogens in critically ill patients with heatstroke: a retrospective multi-center study
This retrospective multicenter study was conducted across 83 intensive care units (ICUs) in 16 cities in Sichuan, China. Critically ill patients diagnosed with heatstroke and lung infections were included in the study. Specimens from the lower respiratory tract were collected for microbiological tes...
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Frontiers Media S.A.
2024-11-01
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| Series: | Frontiers in Cellular and Infection Microbiology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fcimb.2024.1420535/full |
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| author | Aijia Ma Xinyang Jin Yucong Wang Lietao Wang Lvyuan Shi Dingyuan Wan Qin Wu Min He Zhuo Tang Jiajin Li Jian Wang Guangwei Yang Zhongwei Zhang Jing Yang Bo Wang |
| author_facet | Aijia Ma Xinyang Jin Yucong Wang Lietao Wang Lvyuan Shi Dingyuan Wan Qin Wu Min He Zhuo Tang Jiajin Li Jian Wang Guangwei Yang Zhongwei Zhang Jing Yang Bo Wang |
| author_sort | Aijia Ma |
| collection | DOAJ |
| description | This retrospective multicenter study was conducted across 83 intensive care units (ICUs) in 16 cities in Sichuan, China. Critically ill patients diagnosed with heatstroke and lung infections were included in the study. Specimens from the lower respiratory tract were collected for microbiological testing, and the characteristics of the pathogens were described. A total of 462 patients diagnosed with heatstroke-related pulmonary infections were included, 134 patients (29.0%) tested positive for respiratory pathogens. The most frequently isolated strain was Klebsiella pneumoniae (34.3%), followed by Escherichia coli (28.4%), Staphylococcus aureus (20.9%). The results revealed that in the hyperthermic resistance group, there was a higher proportion of Pseudomonas aeruginosa [14(34.1%) vs 11(11.8%), p=0.002] and Stenotrophomonas maltophilia [4(9.8%) vs 1(1.1%), p=0.030] compared to the hyperthermic control group. And a higher proportion of Staphylococcus aureus [27(29.7%) vs 1(2.3%), p<0.001], were obtained during the earlier stages with elevated temperatures. Patients with Klebsiella pneumoniae (38.3 ± 1.9°C), Staphylococcus aureus (38.5 ± 2.2°C), and Pseudomonas aeruginosa (38.7 ± 1.9°C) exhibited a higher temperature environment. Our study provides crucial insights into the lower respiratory tract pathogenesis of heatstroke patients, identifying key pathogens and their temperature-dependent characteristics, thus providing a foundation for future empirical treatment strategies in heatstroke. |
| format | Article |
| id | doaj-art-d0f095e5a6454c06a38494ab6c0a4e46 |
| institution | OA Journals |
| issn | 2235-2988 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cellular and Infection Microbiology |
| spelling | doaj-art-d0f095e5a6454c06a38494ab6c0a4e462025-08-20T01:54:19ZengFrontiers Media S.A.Frontiers in Cellular and Infection Microbiology2235-29882024-11-011410.3389/fcimb.2024.14205351420535Characteristics of lower respiratory tract pathogens in critically ill patients with heatstroke: a retrospective multi-center studyAijia Ma0Xinyang Jin1Yucong Wang2Lietao Wang3Lvyuan Shi4Dingyuan Wan5Qin Wu6Min He7Zhuo Tang8Jiajin Li9Jian Wang10Guangwei Yang11Zhongwei Zhang12Jing Yang13Bo Wang14Department of Critical Care Medicine, West China Hospital of Sichuan University, Chengdu, Sichuan, ChinaSchool of Pharmacy, Macau University of Science and Technology, Macao, Macao SAR, ChinaDepartment of Critical Care Medicine, West China Hospital of Sichuan University, Chengdu, Sichuan, ChinaDepartment of Critical Care Medicine, West China Hospital of Sichuan University, Chengdu, Sichuan, ChinaDepartment of Critical Care Medicine, West China Hospital of Sichuan University, Chengdu, Sichuan, ChinaDepartment of Critical Care Medicine, West China Hospital of Sichuan University, Chengdu, Sichuan, ChinaDepartment of Critical Care Medicine, West China Hospital of Sichuan University, Chengdu, Sichuan, ChinaDepartment of Critical Care Medicine, West China Hospital of Sichuan University, Chengdu, Sichuan, ChinaDepartment of Intensive Care Medicine, Zizhong County Chinese Medicine Hospital, Zizhong, Sichuan, ChinaDepartment of Intensive Care Medicine, Mianyang People’s Hospital, Mianyang, Sichuan, ChinaDepartment of Intensive Care Medicine, Guang’an People’s Hospital, Guang’an, Sichuan, ChinaDepartment of Intensive Care Medicine, Huaying People’s Hospital, Huaying, Sichuan, ChinaDepartment of Critical Care Medicine, West China Hospital of Sichuan University, Chengdu, Sichuan, ChinaDepartment of Critical Care Medicine, West China Hospital of Sichuan University, Chengdu, Sichuan, ChinaDepartment of Critical Care Medicine, West China Hospital of Sichuan University, Chengdu, Sichuan, ChinaThis retrospective multicenter study was conducted across 83 intensive care units (ICUs) in 16 cities in Sichuan, China. Critically ill patients diagnosed with heatstroke and lung infections were included in the study. Specimens from the lower respiratory tract were collected for microbiological testing, and the characteristics of the pathogens were described. A total of 462 patients diagnosed with heatstroke-related pulmonary infections were included, 134 patients (29.0%) tested positive for respiratory pathogens. The most frequently isolated strain was Klebsiella pneumoniae (34.3%), followed by Escherichia coli (28.4%), Staphylococcus aureus (20.9%). The results revealed that in the hyperthermic resistance group, there was a higher proportion of Pseudomonas aeruginosa [14(34.1%) vs 11(11.8%), p=0.002] and Stenotrophomonas maltophilia [4(9.8%) vs 1(1.1%), p=0.030] compared to the hyperthermic control group. And a higher proportion of Staphylococcus aureus [27(29.7%) vs 1(2.3%), p<0.001], were obtained during the earlier stages with elevated temperatures. Patients with Klebsiella pneumoniae (38.3 ± 1.9°C), Staphylococcus aureus (38.5 ± 2.2°C), and Pseudomonas aeruginosa (38.7 ± 1.9°C) exhibited a higher temperature environment. Our study provides crucial insights into the lower respiratory tract pathogenesis of heatstroke patients, identifying key pathogens and their temperature-dependent characteristics, thus providing a foundation for future empirical treatment strategies in heatstroke.https://www.frontiersin.org/articles/10.3389/fcimb.2024.1420535/fullheatstrokelower respiratory tract infectionshigh body temperaturelung pathogenintensive care unit |
| spellingShingle | Aijia Ma Xinyang Jin Yucong Wang Lietao Wang Lvyuan Shi Dingyuan Wan Qin Wu Min He Zhuo Tang Jiajin Li Jian Wang Guangwei Yang Zhongwei Zhang Jing Yang Bo Wang Characteristics of lower respiratory tract pathogens in critically ill patients with heatstroke: a retrospective multi-center study Frontiers in Cellular and Infection Microbiology heatstroke lower respiratory tract infections high body temperature lung pathogen intensive care unit |
| title | Characteristics of lower respiratory tract pathogens in critically ill patients with heatstroke: a retrospective multi-center study |
| title_full | Characteristics of lower respiratory tract pathogens in critically ill patients with heatstroke: a retrospective multi-center study |
| title_fullStr | Characteristics of lower respiratory tract pathogens in critically ill patients with heatstroke: a retrospective multi-center study |
| title_full_unstemmed | Characteristics of lower respiratory tract pathogens in critically ill patients with heatstroke: a retrospective multi-center study |
| title_short | Characteristics of lower respiratory tract pathogens in critically ill patients with heatstroke: a retrospective multi-center study |
| title_sort | characteristics of lower respiratory tract pathogens in critically ill patients with heatstroke a retrospective multi center study |
| topic | heatstroke lower respiratory tract infections high body temperature lung pathogen intensive care unit |
| url | https://www.frontiersin.org/articles/10.3389/fcimb.2024.1420535/full |
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