Case Report: A novel ELMOD3-ALK and EML4-ALK double-fusion responses to neoadjuvant alectinib in a lung adenocarcinoma patient

Case Report: A novel ELMOD3-ALK and EML4-ALK double-fusion responses to neoadjuvant alectinib in a lung adenocarcinoma patient

BackgroundAnaplastic lymphoma kinase (ALK) rearrangements account for approximately 3%–5% of non-small cell lung cancer (NSCLC), and the echinoderm microtubule-associated protein-like 4 gene (EML4) and ALK fusion (EML4-ALK) is the most common ALK rearrangement in NSCLC patients. However, double-ALK...

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Bibliographic Details
Main Authors:	Kaili Huang, Wen Li, Yinyin Xue, Lei Peng, Qiang Wu, Qinghua Zhou
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2025-04-01
Series:	Frontiers in Pharmacology
Subjects:	lung adenocarcinoma ALK ELMOD3 double fusion neoadjuvant alectinib
Online Access:	https://www.frontiersin.org/articles/10.3389/fphar.2025.1515826/full
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