Selenium and selenoprotein deficiencies induce widespread pyogranuloma formation in mice, while high levels of dietary selenium decrease liver tumor size driven by TGFα.

Selenium and selenoprotein deficiencies induce widespread pyogranuloma formation in mice, while high levels of dietary selenium decrease liver tumor size driven by TGFα.

Changes in dietary selenium and selenoprotein status may influence both anti- and pro-cancer pathways, making the outcome of interventions different from one study to another. To characterize such outcomes in a defined setting, we undertook a controlled hepatocarcinogenesis study involving varying l...

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Bibliographic Details
Main Authors: Mohamed E Moustafa, Bradley A Carlson, Miriam R Anver, Gerd Bobe, Nianxin Zhong, Jerrold M Ward, Christine M Perella, Victoria J Hoffmann, Keith Rogers, Gerald F Combs, Ulrich Schweizer, Glenn Merlino, Vadim N Gladyshev, Dolph L Hatfield
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0057389&type=printable
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