Heterogeneity of IGF-1 Levels in Children with hCG-Induced Precocious Puberty
Objective. Sex steroid stimulates growth hormone release during puberty. However, the role of IGF-1 levels in human-chorionic-gonadotropin-induced precocious puberty remains unclear. Methods. A retrospective study reviewing thirty patients with precocious puberty due to human-chorionic-gonadotropin-...
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| Format: | Article |
| Language: | English |
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Wiley
2022-01-01
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| Series: | International Journal of Endocrinology |
| Online Access: | http://dx.doi.org/10.1155/2022/1068896 |
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| author | Han Chen Cai‐Yan Mo Ling-Yu Zhong Li -Yong Zhong |
| author_facet | Han Chen Cai‐Yan Mo Ling-Yu Zhong Li -Yong Zhong |
| author_sort | Han Chen |
| collection | DOAJ |
| description | Objective. Sex steroid stimulates growth hormone release during puberty. However, the role of IGF-1 levels in human-chorionic-gonadotropin-induced precocious puberty remains unclear. Methods. A retrospective study reviewing thirty patients with precocious puberty due to human-chorionic-gonadotropin-secreting intracranial germ cell tumors was performed. Changes in IGF-1 levels were collected. Result. All patients included were boys. At diagnosis, the median IGF-1 standard deviation was 0.87 (0.1, 1.87). When human-chorionic-gonadotropin normalized, the median IGF-1 standard deviation was 1.58 (−0.53, 2.55), which is slightly higher than baseline (p=0.408). When patients completed their therapeutic plan, the median IGF-1 standard deviation was 0.10 (−1.05, 0.68), which was significantly lower than that of baseline (p=0.004) and of human-chorionic-gonadotropin being normalized (p=0.003). At the last visit, the mean IGF-1 standard deviation was −1.11(−1.97, 0.76), which is slightly lower than that of baseline (p=0.109) and post-therapy levels (p=0.575), but significantly lower than that of human-chorionic-gonadotropin being normalized. Two patients had IGF-1 levels above 2 standard deviations at diagnosis, eight at the time when human-chorionic-gonadotropin normalized, and two at the end of therapy. Only one patient had an IGF-1 level below 2 standard deviations at diagnosis and at the time when human-chorionic-gonadotropin normalized, and two patients at the end of therapy. At the last follow-up, all patients had normal IGF-1 levels. Conclusion. IGF-1 levels in patients with human-chorionic-gonadotropin-induced precocious puberty have heterogeneity, but IGF-1 standard deviations are mostly within the normal range. If elevated, it might decline later with a decrease in human-chorionic-gonadotropin level. IGF-1 levels seem not valuable enough to assess human-chorionic-gonadotropin-induced precocity regression. |
| format | Article |
| id | doaj-art-d0e6819c127a4cdabdfb4af6db56224c |
| institution | DOAJ |
| issn | 1687-8345 |
| language | English |
| publishDate | 2022-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Endocrinology |
| spelling | doaj-art-d0e6819c127a4cdabdfb4af6db56224c2025-08-20T03:19:37ZengWileyInternational Journal of Endocrinology1687-83452022-01-01202210.1155/2022/1068896Heterogeneity of IGF-1 Levels in Children with hCG-Induced Precocious PubertyHan Chen0Cai‐Yan Mo1Ling-Yu Zhong2Li -Yong Zhong3Department of EndocrinologyDepartment of EndocrinologyDepartment of EndocrinologyDepartment of EndocrinologyObjective. Sex steroid stimulates growth hormone release during puberty. However, the role of IGF-1 levels in human-chorionic-gonadotropin-induced precocious puberty remains unclear. Methods. A retrospective study reviewing thirty patients with precocious puberty due to human-chorionic-gonadotropin-secreting intracranial germ cell tumors was performed. Changes in IGF-1 levels were collected. Result. All patients included were boys. At diagnosis, the median IGF-1 standard deviation was 0.87 (0.1, 1.87). When human-chorionic-gonadotropin normalized, the median IGF-1 standard deviation was 1.58 (−0.53, 2.55), which is slightly higher than baseline (p=0.408). When patients completed their therapeutic plan, the median IGF-1 standard deviation was 0.10 (−1.05, 0.68), which was significantly lower than that of baseline (p=0.004) and of human-chorionic-gonadotropin being normalized (p=0.003). At the last visit, the mean IGF-1 standard deviation was −1.11(−1.97, 0.76), which is slightly lower than that of baseline (p=0.109) and post-therapy levels (p=0.575), but significantly lower than that of human-chorionic-gonadotropin being normalized. Two patients had IGF-1 levels above 2 standard deviations at diagnosis, eight at the time when human-chorionic-gonadotropin normalized, and two at the end of therapy. Only one patient had an IGF-1 level below 2 standard deviations at diagnosis and at the time when human-chorionic-gonadotropin normalized, and two patients at the end of therapy. At the last follow-up, all patients had normal IGF-1 levels. Conclusion. IGF-1 levels in patients with human-chorionic-gonadotropin-induced precocious puberty have heterogeneity, but IGF-1 standard deviations are mostly within the normal range. If elevated, it might decline later with a decrease in human-chorionic-gonadotropin level. IGF-1 levels seem not valuable enough to assess human-chorionic-gonadotropin-induced precocity regression.http://dx.doi.org/10.1155/2022/1068896 |
| spellingShingle | Han Chen Cai‐Yan Mo Ling-Yu Zhong Li -Yong Zhong Heterogeneity of IGF-1 Levels in Children with hCG-Induced Precocious Puberty International Journal of Endocrinology |
| title | Heterogeneity of IGF-1 Levels in Children with hCG-Induced Precocious Puberty |
| title_full | Heterogeneity of IGF-1 Levels in Children with hCG-Induced Precocious Puberty |
| title_fullStr | Heterogeneity of IGF-1 Levels in Children with hCG-Induced Precocious Puberty |
| title_full_unstemmed | Heterogeneity of IGF-1 Levels in Children with hCG-Induced Precocious Puberty |
| title_short | Heterogeneity of IGF-1 Levels in Children with hCG-Induced Precocious Puberty |
| title_sort | heterogeneity of igf 1 levels in children with hcg induced precocious puberty |
| url | http://dx.doi.org/10.1155/2022/1068896 |
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