Contemporary cohort study in adult patients with infective endocarditis

Background: Infective Endocarditis (IE) is a serious disease, with high morbidity and mortality. Few case series come from middle- income countries. Our aim is to describe a case series of patients with IE treated at a reference center in Brazil and compare data to other countries. Methods: A retros...

Full description

Saved in:
Bibliographic Details
Main Authors: Mariana Giorgi Barroso de Carvalho, Thatyane Veloso de Paula Amaral de Almeida, Nicolas de Albuquerque Pereira Feijóo, Rafael Quaresma Garrido, Giovanna lanini Ferraiuoli Barbosa, Wilma Félix Golebiovski, Bruno Zappa, Clara Weksler, Marcelo Goulart Correia, Cristiane da Cruz Lamas
Format: Article
Language:English
Published: Elsevier 2025-05-01
Series:Brazilian Journal of Infectious Diseases
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S1413867025000248
Tags: Add Tag
No Tags, Be the first to tag this record!
_version_ 1849728003083337728
author Mariana Giorgi Barroso de Carvalho
Thatyane Veloso de Paula Amaral de Almeida
Nicolas de Albuquerque Pereira Feijóo
Rafael Quaresma Garrido
Giovanna lanini Ferraiuoli Barbosa
Wilma Félix Golebiovski
Bruno Zappa
Clara Weksler
Marcelo Goulart Correia
Cristiane da Cruz Lamas
author_facet Mariana Giorgi Barroso de Carvalho
Thatyane Veloso de Paula Amaral de Almeida
Nicolas de Albuquerque Pereira Feijóo
Rafael Quaresma Garrido
Giovanna lanini Ferraiuoli Barbosa
Wilma Félix Golebiovski
Bruno Zappa
Clara Weksler
Marcelo Goulart Correia
Cristiane da Cruz Lamas
author_sort Mariana Giorgi Barroso de Carvalho
collection DOAJ
description Background: Infective Endocarditis (IE) is a serious disease, with high morbidity and mortality. Few case series come from middle- income countries. Our aim is to describe a case series of patients with IE treated at a reference center in Brazil and compare data to other countries. Methods: A retrospective analysis of a prospectively implemented endocarditis database was conducted, including adult patients with definite IE, January 2006‒June 2023. A literature search and summary were done. Statistical analysis was performed using Jamovi®, version 1.2.2. Results: There were 502 episodes of IE; mean age ± SD was 48.4±17.2 years. Community-acquired IE occurred in 64.7 %. Main predispositions were rheumatic valve disease (30.7 %), prostheses (31.5 %), and congenital heart disease (13.9 %). Transthoracic and transesophageal echocardiograms were performed in 85 % and 78 %, respectively. Left-sided IE predominated. Fever occurred in 90.6 %, new murmurs in 50.7 %, and embolism in 45 %. Blood cultures were negative in 33.1 %; frequent pathogens were oral streptococci (15.6 %), Staphylococcus aureus (10.0 %), and enterococci (12.8 %). Main complications were heart failure (58 %), renal failure (32.8 %), and splenic embolization (35.2 %). Surgery was performed in 83.6 %; overall in-hospital mortality was 25 %; surgical mortality was 21.3 %. Conclusions: Blood culture negative left-sided IE predominated. The mortality rate was high but within the range of reported series. Surgery was performed frequently and patients who were operated on had lower mortality.
format Article
id doaj-art-d0e591db053e49c9af54b2dcce66cd85
institution DOAJ
issn 1413-8670
language English
publishDate 2025-05-01
publisher Elsevier
record_format Article
series Brazilian Journal of Infectious Diseases
spelling doaj-art-d0e591db053e49c9af54b2dcce66cd852025-08-20T03:09:42ZengElsevierBrazilian Journal of Infectious Diseases1413-86702025-05-0129310452110.1016/j.bjid.2025.104521Contemporary cohort study in adult patients with infective endocarditisMariana Giorgi Barroso de Carvalho0Thatyane Veloso de Paula Amaral de Almeida1Nicolas de Albuquerque Pereira Feijóo2Rafael Quaresma Garrido3Giovanna lanini Ferraiuoli Barbosa4Wilma Félix Golebiovski5Bruno Zappa6Clara Weksler7Marcelo Goulart Correia8Cristiane da Cruz Lamas9Universidade do Grande Rio/Afya (UNIGRANRIO/Afya), Departamento de Medicina, Rio de Janeiro, RJ, Brazil; Instituto Nacional de Cardiologia, Rio de Janeiro, RJ, BrazilUniversidade do Grande Rio/Afya (UNIGRANRIO/Afya), Departamento de Medicina, Rio de Janeiro, RJ, Brazil; Instituto Nacional de Cardiologia, Rio de Janeiro, RJ, BrazilUniversidade do Grande Rio/Afya (UNIGRANRIO/Afya), Departamento de Medicina, Rio de Janeiro, RJ, Brazil; Instituto Nacional de Cardiologia, Rio de Janeiro, RJ, BrazilInstituto Nacional de Cardiologia, Rio de Janeiro, RJ, BrazilInstituto Nacional de Cardiologia, Rio de Janeiro, RJ, BrazilInstituto Nacional de Cardiologia, Rio de Janeiro, RJ, BrazilInstituto Nacional de Cardiologia, Rio de Janeiro, RJ, BrazilInstituto Nacional de Cardiologia, Rio de Janeiro, RJ, BrazilInstituto Nacional de Cardiologia, Rio de Janeiro, RJ, BrazilInstituto Nacional de Cardiologia, Rio de Janeiro, RJ, Brazil; Instituto Nacional de Infectologia Evandro Chagas (Fiocruz), Rio de Janeiro, RJ, Brazil; Corresponding author.Background: Infective Endocarditis (IE) is a serious disease, with high morbidity and mortality. Few case series come from middle- income countries. Our aim is to describe a case series of patients with IE treated at a reference center in Brazil and compare data to other countries. Methods: A retrospective analysis of a prospectively implemented endocarditis database was conducted, including adult patients with definite IE, January 2006‒June 2023. A literature search and summary were done. Statistical analysis was performed using Jamovi®, version 1.2.2. Results: There were 502 episodes of IE; mean age ± SD was 48.4±17.2 years. Community-acquired IE occurred in 64.7 %. Main predispositions were rheumatic valve disease (30.7 %), prostheses (31.5 %), and congenital heart disease (13.9 %). Transthoracic and transesophageal echocardiograms were performed in 85 % and 78 %, respectively. Left-sided IE predominated. Fever occurred in 90.6 %, new murmurs in 50.7 %, and embolism in 45 %. Blood cultures were negative in 33.1 %; frequent pathogens were oral streptococci (15.6 %), Staphylococcus aureus (10.0 %), and enterococci (12.8 %). Main complications were heart failure (58 %), renal failure (32.8 %), and splenic embolization (35.2 %). Surgery was performed in 83.6 %; overall in-hospital mortality was 25 %; surgical mortality was 21.3 %. Conclusions: Blood culture negative left-sided IE predominated. The mortality rate was high but within the range of reported series. Surgery was performed frequently and patients who were operated on had lower mortality.http://www.sciencedirect.com/science/article/pii/S1413867025000248Infective endocarditisEpidemiologyCohort studySurgeryMortalityBrazil
spellingShingle Mariana Giorgi Barroso de Carvalho
Thatyane Veloso de Paula Amaral de Almeida
Nicolas de Albuquerque Pereira Feijóo
Rafael Quaresma Garrido
Giovanna lanini Ferraiuoli Barbosa
Wilma Félix Golebiovski
Bruno Zappa
Clara Weksler
Marcelo Goulart Correia
Cristiane da Cruz Lamas
Contemporary cohort study in adult patients with infective endocarditis
Brazilian Journal of Infectious Diseases
Infective endocarditis
Epidemiology
Cohort study
Surgery
Mortality
Brazil
title Contemporary cohort study in adult patients with infective endocarditis
title_full Contemporary cohort study in adult patients with infective endocarditis
title_fullStr Contemporary cohort study in adult patients with infective endocarditis
title_full_unstemmed Contemporary cohort study in adult patients with infective endocarditis
title_short Contemporary cohort study in adult patients with infective endocarditis
title_sort contemporary cohort study in adult patients with infective endocarditis
topic Infective endocarditis
Epidemiology
Cohort study
Surgery
Mortality
Brazil
url http://www.sciencedirect.com/science/article/pii/S1413867025000248
work_keys_str_mv AT marianagiorgibarrosodecarvalho contemporarycohortstudyinadultpatientswithinfectiveendocarditis
AT thatyanevelosodepaulaamaraldealmeida contemporarycohortstudyinadultpatientswithinfectiveendocarditis
AT nicolasdealbuquerquepereirafeijoo contemporarycohortstudyinadultpatientswithinfectiveendocarditis
AT rafaelquaresmagarrido contemporarycohortstudyinadultpatientswithinfectiveendocarditis
AT giovannalaniniferraiuolibarbosa contemporarycohortstudyinadultpatientswithinfectiveendocarditis
AT wilmafelixgolebiovski contemporarycohortstudyinadultpatientswithinfectiveendocarditis
AT brunozappa contemporarycohortstudyinadultpatientswithinfectiveendocarditis
AT claraweksler contemporarycohortstudyinadultpatientswithinfectiveendocarditis
AT marcelogoulartcorreia contemporarycohortstudyinadultpatientswithinfectiveendocarditis
AT cristianedacruzlamas contemporarycohortstudyinadultpatientswithinfectiveendocarditis