Nuclear Receptors in Regulation of Mouse ES Cell Pluripotency and Differentiation
Embryonic stem (ES) cells have great therapeutic potential because they are capable of indefinite self-renewal and have the potential to differentiate into over 200 different cell types that compose the human body. The switch from the pluripotent phenotype to a differentiated cell involves many comp...
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| Format: | Article |
| Language: | English |
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Wiley
2007-01-01
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| Series: | PPAR Research |
| Online Access: | http://dx.doi.org/10.1155/2007/61563 |
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| author | Eimear M. Mullen Peili Gu Austin J. Cooney |
| author_facet | Eimear M. Mullen Peili Gu Austin J. Cooney |
| author_sort | Eimear M. Mullen |
| collection | DOAJ |
| description | Embryonic stem (ES) cells have great therapeutic potential because they are capable of indefinite self-renewal and have the potential to differentiate into over 200 different cell types that compose the human body. The switch from the pluripotent phenotype to a differentiated cell involves many complex signaling pathways including those involving LIF/Stat3 and the transcription factors Sox2, Nanog and Oct-4. Many nuclear receptors play an important role in the maintenance of pluripotence (ERRβ, SF-1, LRH-1, DAX-1) repression of the ES cell phenotype (RAR, RXR, GCNF) and also the differentiation of ES cells (PPARγ). Here we review the roles of the nuclear receptors involved in regulating these important processes in ES cells. |
| format | Article |
| id | doaj-art-d0e1a8d59d1c4446a995e062063f4ce8 |
| institution | DOAJ |
| issn | 1687-4757 1687-4765 |
| language | English |
| publishDate | 2007-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | PPAR Research |
| spelling | doaj-art-d0e1a8d59d1c4446a995e062063f4ce82025-08-20T03:19:37ZengWileyPPAR Research1687-47571687-47652007-01-01200710.1155/2007/6156361563Nuclear Receptors in Regulation of Mouse ES Cell Pluripotency and DifferentiationEimear M. Mullen0Peili Gu1Austin J. Cooney2Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USADepartment of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USADepartment of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USAEmbryonic stem (ES) cells have great therapeutic potential because they are capable of indefinite self-renewal and have the potential to differentiate into over 200 different cell types that compose the human body. The switch from the pluripotent phenotype to a differentiated cell involves many complex signaling pathways including those involving LIF/Stat3 and the transcription factors Sox2, Nanog and Oct-4. Many nuclear receptors play an important role in the maintenance of pluripotence (ERRβ, SF-1, LRH-1, DAX-1) repression of the ES cell phenotype (RAR, RXR, GCNF) and also the differentiation of ES cells (PPARγ). Here we review the roles of the nuclear receptors involved in regulating these important processes in ES cells.http://dx.doi.org/10.1155/2007/61563 |
| spellingShingle | Eimear M. Mullen Peili Gu Austin J. Cooney Nuclear Receptors in Regulation of Mouse ES Cell Pluripotency and Differentiation PPAR Research |
| title | Nuclear Receptors in Regulation of Mouse ES Cell Pluripotency and Differentiation |
| title_full | Nuclear Receptors in Regulation of Mouse ES Cell Pluripotency and Differentiation |
| title_fullStr | Nuclear Receptors in Regulation of Mouse ES Cell Pluripotency and Differentiation |
| title_full_unstemmed | Nuclear Receptors in Regulation of Mouse ES Cell Pluripotency and Differentiation |
| title_short | Nuclear Receptors in Regulation of Mouse ES Cell Pluripotency and Differentiation |
| title_sort | nuclear receptors in regulation of mouse es cell pluripotency and differentiation |
| url | http://dx.doi.org/10.1155/2007/61563 |
| work_keys_str_mv | AT eimearmmullen nuclearreceptorsinregulationofmouseescellpluripotencyanddifferentiation AT peiligu nuclearreceptorsinregulationofmouseescellpluripotencyanddifferentiation AT austinjcooney nuclearreceptorsinregulationofmouseescellpluripotencyanddifferentiation |