Epigenetic Regulation of Dental Pulp Stem Cell Fate
Epigenetic regulation, mainly involving DNA methylation, histone modification, and noncoding RNAs, affects gene expression without modifying the primary DNA sequence and modulates cell fate. Mesenchymal stem cells derived from dental pulp, also called dental pulp stem cells (DPSCs), exhibit multipot...
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| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2020-01-01
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| Series: | Stem Cells International |
| Online Access: | http://dx.doi.org/10.1155/2020/8876265 |
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| _version_ | 1850172526494220288 |
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| author | Dan Zhou Lu Gan Yiran Peng Yachuan Zhou Xin Zhou Mian Wan Yi Fan Xin Xu Xuedong Zhou Liwei Zheng Wei Du |
| author_facet | Dan Zhou Lu Gan Yiran Peng Yachuan Zhou Xin Zhou Mian Wan Yi Fan Xin Xu Xuedong Zhou Liwei Zheng Wei Du |
| author_sort | Dan Zhou |
| collection | DOAJ |
| description | Epigenetic regulation, mainly involving DNA methylation, histone modification, and noncoding RNAs, affects gene expression without modifying the primary DNA sequence and modulates cell fate. Mesenchymal stem cells derived from dental pulp, also called dental pulp stem cells (DPSCs), exhibit multipotent differentiation capacity and can promote various biological processes, including odontogenesis, osteogenesis, angiogenesis, myogenesis, and chondrogenesis. Over the past decades, increased attention has been attracted by the use of DPSCs in the field of regenerative medicine. According to a series of studies, epigenetic regulation is essential for DPSCs to differentiate into specialized cells. In this review, we summarize the mechanisms involved in the epigenetic regulation of the fate of DPSCs. |
| format | Article |
| id | doaj-art-d0df6f8922dc4e25918bfc98b3d95d25 |
| institution | OA Journals |
| issn | 1687-966X 1687-9678 |
| language | English |
| publishDate | 2020-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Stem Cells International |
| spelling | doaj-art-d0df6f8922dc4e25918bfc98b3d95d252025-08-20T02:20:03ZengWileyStem Cells International1687-966X1687-96782020-01-01202010.1155/2020/88762658876265Epigenetic Regulation of Dental Pulp Stem Cell FateDan Zhou0Lu Gan1Yiran Peng2Yachuan Zhou3Xin Zhou4Mian Wan5Yi Fan6Xin Xu7Xuedong Zhou8Liwei Zheng9Wei Du10State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, Department of Pediatric Dentistry, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan 610041, ChinaState Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, Department of Pediatric Dentistry, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan 610041, ChinaState Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, Department of Pediatric Dentistry, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan 610041, ChinaState Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, Department of Cariology and Endodontics, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan 610041, ChinaState Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, Department of Pediatric Dentistry, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan 610041, ChinaState Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, Department of Cariology and Endodontics, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan 610041, ChinaState Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, Department of Cariology and Endodontics, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan 610041, ChinaState Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, Department of Cariology and Endodontics, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan 610041, ChinaState Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, Department of Cariology and Endodontics, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan 610041, ChinaState Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, Department of Pediatric Dentistry, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan 610041, ChinaState Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, Department of Cariology and Endodontics, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan 610041, ChinaEpigenetic regulation, mainly involving DNA methylation, histone modification, and noncoding RNAs, affects gene expression without modifying the primary DNA sequence and modulates cell fate. Mesenchymal stem cells derived from dental pulp, also called dental pulp stem cells (DPSCs), exhibit multipotent differentiation capacity and can promote various biological processes, including odontogenesis, osteogenesis, angiogenesis, myogenesis, and chondrogenesis. Over the past decades, increased attention has been attracted by the use of DPSCs in the field of regenerative medicine. According to a series of studies, epigenetic regulation is essential for DPSCs to differentiate into specialized cells. In this review, we summarize the mechanisms involved in the epigenetic regulation of the fate of DPSCs.http://dx.doi.org/10.1155/2020/8876265 |
| spellingShingle | Dan Zhou Lu Gan Yiran Peng Yachuan Zhou Xin Zhou Mian Wan Yi Fan Xin Xu Xuedong Zhou Liwei Zheng Wei Du Epigenetic Regulation of Dental Pulp Stem Cell Fate Stem Cells International |
| title | Epigenetic Regulation of Dental Pulp Stem Cell Fate |
| title_full | Epigenetic Regulation of Dental Pulp Stem Cell Fate |
| title_fullStr | Epigenetic Regulation of Dental Pulp Stem Cell Fate |
| title_full_unstemmed | Epigenetic Regulation of Dental Pulp Stem Cell Fate |
| title_short | Epigenetic Regulation of Dental Pulp Stem Cell Fate |
| title_sort | epigenetic regulation of dental pulp stem cell fate |
| url | http://dx.doi.org/10.1155/2020/8876265 |
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