Communication between host organism and cancer cells is transduced by systemic sphingosine kinase 1/sphingosine 1‐phosphate signalling to regulate tumour metastasis

Communication between host organism and cancer cells is transduced by systemic sphingosine kinase 1/sphingosine 1‐phosphate signalling to regulate tumour metastasis

Abstract Mechanisms by which cancer cells communicate with the host organism to regulate lung colonization/metastasis are unclear. We show that this communication occurs via sphingosine 1‐phosphate (S1P) generated systemically by sphingosine kinase 1 (SK1), rather than via tumour‐derived S1P. Modula...

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Bibliographic Details
Main Authors: Suriyan Ponnusamy, Shanmugam Panneer Selvam, Shikhar Mehrotra, Toshihiko Kawamori, Ashley J. Snider, Lina M. Obeid, Yuan Shao, Roger Sabbadini, Besim Ogretmen
Format: Article
Language:English
Published: Springer Nature 2012-06-01
Series:EMBO Molecular Medicine
Subjects:
lung metastasis
sphingolipids
sphingomab
sphingosine kinase 1
sphingosine 1‐phosphate
Online Access:https://doi.org/10.1002/emmm.201200244
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