Case of acute drug-induced hepatitis after halothane anesthesia
The aim of publication. To present the case of severe acute drug-induced hepatitis after halothane anesthesia in relation to significance of allergies history preoperative inquiry and assessment of medical management of patients, using modern prognostic scales.Key points. Biotransformation of volati...
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| Format: | Article |
| Language: | Russian |
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Gastro LLC
2013-05-01
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| Series: | Российский журнал гастроэнтерологии, гепатологии, колопроктологии |
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| Online Access: | https://www.gastro-j.ru/jour/article/view/1192 |
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| author | I. Yu. Pirogova Ye. V. Berestova O. Yu. Bastrikov Ye. B. Kovaleva T. P. Petukhova M. V. Guseva I. A. Gubina I. V. Rezepin S. P. Sinitsyn |
| author_facet | I. Yu. Pirogova Ye. V. Berestova O. Yu. Bastrikov Ye. B. Kovaleva T. P. Petukhova M. V. Guseva I. A. Gubina I. V. Rezepin S. P. Sinitsyn |
| author_sort | I. Yu. Pirogova |
| collection | DOAJ |
| description | The aim of publication. To present the case of severe acute drug-induced hepatitis after halothane anesthesia in relation to significance of allergies history preoperative inquiry and assessment of medical management of patients, using modern prognostic scales.Key points. Biotransformation of volatile anesthetics can result in production of toxic metabolites and metabolic by-products, resulting in damage of the liver and kidneys. Disorders of liver function can be of two types: early – transient elevation of transaminase activity and late – liver necrosis. Mortality rate at the latter reaches 50–80%. In presented clinical case both variants developed in the same patient in different terms are described. Despite of acute drug-induced hepatitis with severe liver failure, complex treatment resulted in favorable outcome, including the remote-terms result.Conclusion. The most important factors determining favorable prognosis at drug-induced liver disease, include adequate doses of glucocorticosteroids, application of MARS-therapy and absence of background liver disease. Application of differential diagnostics algorithms and prognostic scales at drug-induced liver disease helps clinician to choose proper treatment approach at specific stage. |
| format | Article |
| id | doaj-art-d0d77738a8674fc99f594d435aaf976d |
| institution | Kabale University |
| issn | 1382-4376 2658-6673 |
| language | Russian |
| publishDate | 2013-05-01 |
| publisher | Gastro LLC |
| record_format | Article |
| series | Российский журнал гастроэнтерологии, гепатологии, колопроктологии |
| spelling | doaj-art-d0d77738a8674fc99f594d435aaf976d2025-02-10T16:14:32ZrusGastro LLCРоссийский журнал гастроэнтерологии, гепатологии, колопроктологии1382-43762658-66732013-05-012323640776Case of acute drug-induced hepatitis after halothane anesthesiaI. Yu. Pirogova0Ye. V. Berestova1O. Yu. Bastrikov2Ye. B. Kovaleva3T. P. Petukhova4M. V. Guseva5I. A. Gubina6I. V. Rezepin7S. P. Sinitsyn8State educational government-financed institution of higher professional education «Chelyabinsk state medical academy»Municipal healthcare institution, city clinical hospital N 8State educational government-financed institution of higher professional education «Chelyabinsk state medical academy»Municipal healthcare institution, city clinical hospital N 3Municipal healthcare institution, city clinical hospital N 3Municipal healthcare institution, city clinical hospital N 8Municipal healthcare institution, city clinical hospital N 8Municipal healthcare institution, city clinical hospital N 3State educational government-financed institution of higher professional education «Chelyabinsk state medical academy»The aim of publication. To present the case of severe acute drug-induced hepatitis after halothane anesthesia in relation to significance of allergies history preoperative inquiry and assessment of medical management of patients, using modern prognostic scales.Key points. Biotransformation of volatile anesthetics can result in production of toxic metabolites and metabolic by-products, resulting in damage of the liver and kidneys. Disorders of liver function can be of two types: early – transient elevation of transaminase activity and late – liver necrosis. Mortality rate at the latter reaches 50–80%. In presented clinical case both variants developed in the same patient in different terms are described. Despite of acute drug-induced hepatitis with severe liver failure, complex treatment resulted in favorable outcome, including the remote-terms result.Conclusion. The most important factors determining favorable prognosis at drug-induced liver disease, include adequate doses of glucocorticosteroids, application of MARS-therapy and absence of background liver disease. Application of differential diagnostics algorithms and prognostic scales at drug-induced liver disease helps clinician to choose proper treatment approach at specific stage.https://www.gastro-j.ru/jour/article/view/1192acute drug-induced hepatitishalothane anesthesia |
| spellingShingle | I. Yu. Pirogova Ye. V. Berestova O. Yu. Bastrikov Ye. B. Kovaleva T. P. Petukhova M. V. Guseva I. A. Gubina I. V. Rezepin S. P. Sinitsyn Case of acute drug-induced hepatitis after halothane anesthesia Российский журнал гастроэнтерологии, гепатологии, колопроктологии acute drug-induced hepatitis halothane anesthesia |
| title | Case of acute drug-induced hepatitis after halothane anesthesia |
| title_full | Case of acute drug-induced hepatitis after halothane anesthesia |
| title_fullStr | Case of acute drug-induced hepatitis after halothane anesthesia |
| title_full_unstemmed | Case of acute drug-induced hepatitis after halothane anesthesia |
| title_short | Case of acute drug-induced hepatitis after halothane anesthesia |
| title_sort | case of acute drug induced hepatitis after halothane anesthesia |
| topic | acute drug-induced hepatitis halothane anesthesia |
| url | https://www.gastro-j.ru/jour/article/view/1192 |
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