Association of Japanese cedar pollen sensitization in children with Dermatophagoides pteronyssinus sensitization and maternal sensitization: Insights from the Yamanashi adjunct study within the Japan Environment and Children’s Study (JECS)
Background: In recent years, the prevalence of allergic rhinitis (AR) in Japanese children has increased significantly. Multiple sensitization and genetic factors are associated with the development of AR, and moreover, multiply sensitized children are more likely to have parents with AR. This resea...
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Elsevier
2025-04-01
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| Series: | Allergology International |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1323893024001254 |
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| author | Ayumi Shimamura Ryoji Shinohara Megumi Kushima Sanae Otawa Hideki Yui Tomokazu Matsuoka Daisuke Watanabe Hiroshi Yokomichi Kunio Miyake Reiji Kojima Zentaro Yamagata Daiju Sakurai |
| author_facet | Ayumi Shimamura Ryoji Shinohara Megumi Kushima Sanae Otawa Hideki Yui Tomokazu Matsuoka Daisuke Watanabe Hiroshi Yokomichi Kunio Miyake Reiji Kojima Zentaro Yamagata Daiju Sakurai |
| author_sort | Ayumi Shimamura |
| collection | DOAJ |
| description | Background: In recent years, the prevalence of allergic rhinitis (AR) in Japanese children has increased significantly. Multiple sensitization and genetic factors are associated with the development of AR, and moreover, multiply sensitized children are more likely to have parents with AR. This research investigated the association of Japanese cedar pollen (JCP) sensitization in children with Dermatophagoides pteronyssinus (DP) sensitization and with maternal JCP sensitization. Methods: This is an Adjunct Study to the Japan Environment and Children’s Study (JECS) in Yamanashi where reports the highest positive rate of JCP sensitization. It included 1469 mother-child pairs who participated in a comprehensive health examination of 8-year-old children (from 2019 to 2022) at the JECS-Yamanashi. Univariate and multivariate logistic regression models were created using the presence/absence of child’s JCP sensitization as the objective variable; mother’s JCP sensitization and child’s DP sensitization as explanatory variables; and child’s sex and BMI, mother’s age, and JCP exposure in the examination year as adjustment variables. Results: Children who were positive for DP sensitization were also more likely to be positive for JCP sensitization (adjusted OR: 6.58; 95%CI: 5.10–8.48; P < 0.001). Children who were positive for DP sensitization were also more likely to be positive for JCP sensitization if their mothers were positive for JCP sensitization (adjusted OR: 1.77; 95%CI: 1.16–2.71; P = 0.008). Conclusions: JCP sensitization is associated with DP sensitization in children. Furthermore, in DP sensitization-positive children, JCP sensitization of the child was associated with JCP sensitization of the mother. |
| format | Article |
| id | doaj-art-d0d63f8fe7874d30a346af1194e302e0 |
| institution | DOAJ |
| issn | 1323-8930 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Allergology International |
| spelling | doaj-art-d0d63f8fe7874d30a346af1194e302e02025-08-20T02:48:18ZengElsevierAllergology International1323-89302025-04-0174230130710.1016/j.alit.2024.11.002Association of Japanese cedar pollen sensitization in children with Dermatophagoides pteronyssinus sensitization and maternal sensitization: Insights from the Yamanashi adjunct study within the Japan Environment and Children’s Study (JECS)Ayumi Shimamura0Ryoji Shinohara1Megumi Kushima2Sanae Otawa3Hideki Yui4Tomokazu Matsuoka5Daisuke Watanabe6Hiroshi Yokomichi7Kunio Miyake8Reiji Kojima9Zentaro Yamagata10Daiju Sakurai11Department of Otolaryngology, Head and Neck Surgery, University of Yamanashi, Yamanashi, JapanCenter for Birth Cohort Studies, Interdisciplinary Graduate, University of Yamanashi, Yamanashi, JapanCenter for Birth Cohort Studies, Interdisciplinary Graduate, University of Yamanashi, Yamanashi, JapanCenter for Birth Cohort Studies, Interdisciplinary Graduate, University of Yamanashi, Yamanashi, JapanCenter for Birth Cohort Studies, Interdisciplinary Graduate, University of Yamanashi, Yamanashi, JapanDepartment of Otolaryngology, Head and Neck Surgery, University of Yamanashi, Yamanashi, JapanDepartment of Otolaryngology, Head and Neck Surgery, University of Yamanashi, Yamanashi, JapanDepartment of Epidemiology and Environmental Medicine, University of Yamanashi, Yamanashi, JapanDepartment of Epidemiology and Environmental Medicine, University of Yamanashi, Yamanashi, JapanDepartment of Epidemiology and Environmental Medicine, University of Yamanashi, Yamanashi, JapanCenter for Birth Cohort Studies, Interdisciplinary Graduate, University of Yamanashi, Yamanashi, JapanDepartment of Otolaryngology, Head and Neck Surgery, University of Yamanashi, Yamanashi, Japan; Corresponding author. Department of Otolaryngology, Head and Neck Surgery, University of Yamanashi, 1110 Shimokato, Chuo, Yamanashi, Japan.Background: In recent years, the prevalence of allergic rhinitis (AR) in Japanese children has increased significantly. Multiple sensitization and genetic factors are associated with the development of AR, and moreover, multiply sensitized children are more likely to have parents with AR. This research investigated the association of Japanese cedar pollen (JCP) sensitization in children with Dermatophagoides pteronyssinus (DP) sensitization and with maternal JCP sensitization. Methods: This is an Adjunct Study to the Japan Environment and Children’s Study (JECS) in Yamanashi where reports the highest positive rate of JCP sensitization. It included 1469 mother-child pairs who participated in a comprehensive health examination of 8-year-old children (from 2019 to 2022) at the JECS-Yamanashi. Univariate and multivariate logistic regression models were created using the presence/absence of child’s JCP sensitization as the objective variable; mother’s JCP sensitization and child’s DP sensitization as explanatory variables; and child’s sex and BMI, mother’s age, and JCP exposure in the examination year as adjustment variables. Results: Children who were positive for DP sensitization were also more likely to be positive for JCP sensitization (adjusted OR: 6.58; 95%CI: 5.10–8.48; P < 0.001). Children who were positive for DP sensitization were also more likely to be positive for JCP sensitization if their mothers were positive for JCP sensitization (adjusted OR: 1.77; 95%CI: 1.16–2.71; P = 0.008). Conclusions: JCP sensitization is associated with DP sensitization in children. Furthermore, in DP sensitization-positive children, JCP sensitization of the child was associated with JCP sensitization of the mother.http://www.sciencedirect.com/science/article/pii/S1323893024001254Dermatophagoides pteronyssinusImmunoglobulin EMother–child relationsPollenSeasonal allergic rhinitis |
| spellingShingle | Ayumi Shimamura Ryoji Shinohara Megumi Kushima Sanae Otawa Hideki Yui Tomokazu Matsuoka Daisuke Watanabe Hiroshi Yokomichi Kunio Miyake Reiji Kojima Zentaro Yamagata Daiju Sakurai Association of Japanese cedar pollen sensitization in children with Dermatophagoides pteronyssinus sensitization and maternal sensitization: Insights from the Yamanashi adjunct study within the Japan Environment and Children’s Study (JECS) Allergology International Dermatophagoides pteronyssinus Immunoglobulin E Mother–child relations Pollen Seasonal allergic rhinitis |
| title | Association of Japanese cedar pollen sensitization in children with Dermatophagoides pteronyssinus sensitization and maternal sensitization: Insights from the Yamanashi adjunct study within the Japan Environment and Children’s Study (JECS) |
| title_full | Association of Japanese cedar pollen sensitization in children with Dermatophagoides pteronyssinus sensitization and maternal sensitization: Insights from the Yamanashi adjunct study within the Japan Environment and Children’s Study (JECS) |
| title_fullStr | Association of Japanese cedar pollen sensitization in children with Dermatophagoides pteronyssinus sensitization and maternal sensitization: Insights from the Yamanashi adjunct study within the Japan Environment and Children’s Study (JECS) |
| title_full_unstemmed | Association of Japanese cedar pollen sensitization in children with Dermatophagoides pteronyssinus sensitization and maternal sensitization: Insights from the Yamanashi adjunct study within the Japan Environment and Children’s Study (JECS) |
| title_short | Association of Japanese cedar pollen sensitization in children with Dermatophagoides pteronyssinus sensitization and maternal sensitization: Insights from the Yamanashi adjunct study within the Japan Environment and Children’s Study (JECS) |
| title_sort | association of japanese cedar pollen sensitization in children with dermatophagoides pteronyssinus sensitization and maternal sensitization insights from the yamanashi adjunct study within the japan environment and children s study jecs |
| topic | Dermatophagoides pteronyssinus Immunoglobulin E Mother–child relations Pollen Seasonal allergic rhinitis |
| url | http://www.sciencedirect.com/science/article/pii/S1323893024001254 |
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