Histological Alterations Induced by Atorvastatin Therapeutic Doses in some Organs of Male Albino Rats
Vascular disease and heart attacks are a common phenomenon in the modern world, where lipid accumulates inside blood vessels and causes plug, eventually heart stroke and death. Utilize lipidlowering drugs are the most effective factors to prevent heart disease. Atorvastatin is the most important dru...
Saved in:
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Erbil Polytechnic University
2019-04-01
|
| Series: | Polytechnic Journal |
| Subjects: | |
| Online Access: | https://polytechnic-journal.epu.edu.iq/home/vol9/iss1/4 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850172522839932928 |
|---|---|
| author | Twana Ahmed Mustafa Hamza Osman Abdulah |
| author_facet | Twana Ahmed Mustafa Hamza Osman Abdulah |
| author_sort | Twana Ahmed Mustafa |
| collection | DOAJ |
| description | Vascular disease and heart attacks are a common phenomenon in the modern world, where lipid
accumulates inside blood vessels and causes plug, eventually heart stroke and death. Utilize lipidlowering drugs are the most effective factors to prevent heart disease. Atorvastatin is the most
important drugs that used in this field. The aim of this study was to investigate the adverse effects
of atorvastatin (20 mg/kg/b.wt/day) on some organs of albino. 12 adult male albino rats weighing
200 ± 20 g were used and divided into two groups: First group served as control group, was given
0.72 ml distilled water/rat. The second group was subjected to treatments with atorvastatin in a
dose of 20 mg/kg/b.wt/day as a single daily dose (0.72 ml contained 1.44 mg of atorvastatin) orally
by gastric tube for 4 weeks. Histological alterations were examined, and the results of atorvastatintreated groups showed changes in the kidney sections, which include focal tubular edema and
glomerular atrophy, also liver sections revealed foci of lymphocyte accumulation, cytoplasmic
vacuolization, as well as sections of the testes showed degenerative changes in the seminiferous
tubules. According to this study, we can conclude that atorvastatin-induced various deleterious
changes in the histological structure of the testes, kidneys and cause mild liver alteration of adult
male albino rat. |
| format | Article |
| id | doaj-art-d0d4b35dc3a94929baa42d81be128322 |
| institution | OA Journals |
| issn | 2707-7799 |
| language | English |
| publishDate | 2019-04-01 |
| publisher | Erbil Polytechnic University |
| record_format | Article |
| series | Polytechnic Journal |
| spelling | doaj-art-d0d4b35dc3a94929baa42d81be1283222025-08-20T02:20:03ZengErbil Polytechnic UniversityPolytechnic Journal2707-77992019-04-01911316https://doi.org/10.25156/ptj.v9n1y2019.pp13-16Histological Alterations Induced by Atorvastatin Therapeutic Doses in some Organs of Male Albino RatsTwana Ahmed Mustafa0Hamza Osman Abdulah1Department of Med. Lab Technique, Erbil Polytechnic University, Health Technical College, Erbil, Iraqi KurdistanDepartment of Histopathology, Shar Hospital, Sulaimania, Iraqi KurdistanVascular disease and heart attacks are a common phenomenon in the modern world, where lipid accumulates inside blood vessels and causes plug, eventually heart stroke and death. Utilize lipidlowering drugs are the most effective factors to prevent heart disease. Atorvastatin is the most important drugs that used in this field. The aim of this study was to investigate the adverse effects of atorvastatin (20 mg/kg/b.wt/day) on some organs of albino. 12 adult male albino rats weighing 200 ± 20 g were used and divided into two groups: First group served as control group, was given 0.72 ml distilled water/rat. The second group was subjected to treatments with atorvastatin in a dose of 20 mg/kg/b.wt/day as a single daily dose (0.72 ml contained 1.44 mg of atorvastatin) orally by gastric tube for 4 weeks. Histological alterations were examined, and the results of atorvastatintreated groups showed changes in the kidney sections, which include focal tubular edema and glomerular atrophy, also liver sections revealed foci of lymphocyte accumulation, cytoplasmic vacuolization, as well as sections of the testes showed degenerative changes in the seminiferous tubules. According to this study, we can conclude that atorvastatin-induced various deleterious changes in the histological structure of the testes, kidneys and cause mild liver alteration of adult male albino rat. https://polytechnic-journal.epu.edu.iq/home/vol9/iss1/4atorvastatin;kidney;liver;rats;testis |
| spellingShingle | Twana Ahmed Mustafa Hamza Osman Abdulah Histological Alterations Induced by Atorvastatin Therapeutic Doses in some Organs of Male Albino Rats Polytechnic Journal atorvastatin; kidney; liver; rats; testis |
| title | Histological Alterations Induced by Atorvastatin Therapeutic Doses in some Organs of Male Albino Rats |
| title_full | Histological Alterations Induced by Atorvastatin Therapeutic Doses in some Organs of Male Albino Rats |
| title_fullStr | Histological Alterations Induced by Atorvastatin Therapeutic Doses in some Organs of Male Albino Rats |
| title_full_unstemmed | Histological Alterations Induced by Atorvastatin Therapeutic Doses in some Organs of Male Albino Rats |
| title_short | Histological Alterations Induced by Atorvastatin Therapeutic Doses in some Organs of Male Albino Rats |
| title_sort | histological alterations induced by atorvastatin therapeutic doses in some organs of male albino rats |
| topic | atorvastatin; kidney; liver; rats; testis |
| url | https://polytechnic-journal.epu.edu.iq/home/vol9/iss1/4 |
| work_keys_str_mv | AT twanaahmedmustafa histologicalalterationsinducedbyatorvastatintherapeuticdosesinsomeorgansofmalealbinorats AT hamzaosmanabdulah histologicalalterationsinducedbyatorvastatintherapeuticdosesinsomeorgansofmalealbinorats |