The Application of Functional Magnetic Resonance Imaging in an Infant Rat Model of Irritable Bowel Syndrome
The aim of this study was to use functional magnetic resonance imaging (BOLD-fMRI) to investigate the activated region associated with visceral pain in the brains of infant rats in a model of IBS. Sixteen newborn rats were randomized into an IBS model group and a control group. Those in the IBS grou...
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| Format: | Article |
| Language: | English |
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Wiley
2014-01-01
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| Series: | Gastroenterology Research and Practice |
| Online Access: | http://dx.doi.org/10.1155/2014/473846 |
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| author | Xueping Zhu Xiaoli Zhu Weichang Chen Jianhua Chen |
| author_facet | Xueping Zhu Xiaoli Zhu Weichang Chen Jianhua Chen |
| author_sort | Xueping Zhu |
| collection | DOAJ |
| description | The aim of this study was to use functional magnetic resonance imaging (BOLD-fMRI) to investigate the activated region associated with visceral pain in the brains of infant rats in a model of IBS. Sixteen newborn rats were randomized into an IBS model group and a control group. Those in the IBS group were separated from their mothers and were mechanically immobilized and had rectal sensitization with mustard essential oil for 1 week. The control group had no treatment. After 2 weeks, balloon catheters were inflated with 5 or 10 mL of air in the rectums of both groups. BOLD-fMRI was performed and the data analyzed by imaging software. In the IBS model group, rectal stimulation with 5 mL air distension activated the anterior cingulate cortex, insula cortex (IC), prefrontal cortex (PFC), and thalamus, while 10 mL air significantly activated the ACC, IC, PFC, and thalamus in the model, but not controls. IBS model group was hypersensitive to visceral stimulation by rectal balloon inflation. The major brain areas participating in visceral sensation included the IC, PFC, and thalamus. |
| format | Article |
| id | doaj-art-d0d0729a3f804f5fa9f13cd0f0813b42 |
| institution | DOAJ |
| issn | 1687-6121 1687-630X |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Gastroenterology Research and Practice |
| spelling | doaj-art-d0d0729a3f804f5fa9f13cd0f0813b422025-08-20T03:19:37ZengWileyGastroenterology Research and Practice1687-61211687-630X2014-01-01201410.1155/2014/473846473846The Application of Functional Magnetic Resonance Imaging in an Infant Rat Model of Irritable Bowel SyndromeXueping Zhu0Xiaoli Zhu1Weichang Chen2Jianhua Chen3Department of Neonatology, Soochow University Affiliated Children’s Hospital, Suzhou 215003, ChinaDepartment of Intervention, The First Affiliated Hospital of Soochow University, Suzhou 215006, ChinaDepartment of Gastroenterology, The First Affiliated Hospital of Soochow University, Suzhou 215006, ChinaDepartment of Medical Imaging, The First Affiliated Hospital of Soochow University, Suzhou 215006, ChinaThe aim of this study was to use functional magnetic resonance imaging (BOLD-fMRI) to investigate the activated region associated with visceral pain in the brains of infant rats in a model of IBS. Sixteen newborn rats were randomized into an IBS model group and a control group. Those in the IBS group were separated from their mothers and were mechanically immobilized and had rectal sensitization with mustard essential oil for 1 week. The control group had no treatment. After 2 weeks, balloon catheters were inflated with 5 or 10 mL of air in the rectums of both groups. BOLD-fMRI was performed and the data analyzed by imaging software. In the IBS model group, rectal stimulation with 5 mL air distension activated the anterior cingulate cortex, insula cortex (IC), prefrontal cortex (PFC), and thalamus, while 10 mL air significantly activated the ACC, IC, PFC, and thalamus in the model, but not controls. IBS model group was hypersensitive to visceral stimulation by rectal balloon inflation. The major brain areas participating in visceral sensation included the IC, PFC, and thalamus.http://dx.doi.org/10.1155/2014/473846 |
| spellingShingle | Xueping Zhu Xiaoli Zhu Weichang Chen Jianhua Chen The Application of Functional Magnetic Resonance Imaging in an Infant Rat Model of Irritable Bowel Syndrome Gastroenterology Research and Practice |
| title | The Application of Functional Magnetic Resonance Imaging in an Infant Rat Model of Irritable Bowel Syndrome |
| title_full | The Application of Functional Magnetic Resonance Imaging in an Infant Rat Model of Irritable Bowel Syndrome |
| title_fullStr | The Application of Functional Magnetic Resonance Imaging in an Infant Rat Model of Irritable Bowel Syndrome |
| title_full_unstemmed | The Application of Functional Magnetic Resonance Imaging in an Infant Rat Model of Irritable Bowel Syndrome |
| title_short | The Application of Functional Magnetic Resonance Imaging in an Infant Rat Model of Irritable Bowel Syndrome |
| title_sort | application of functional magnetic resonance imaging in an infant rat model of irritable bowel syndrome |
| url | http://dx.doi.org/10.1155/2014/473846 |
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