Effects of calorie restriction on the lifespan and healthspan of POLG mitochondrial mutator mice.

Effects of calorie restriction on the lifespan and healthspan of POLG mitochondrial mutator mice.

Mitochondrial DNA (mtDNA) mutations are thought to have a causative role in age-related pathologies. We have shown previously that mitochondrial mutator mice (PolgD257A/D257A), harboring a proofreading-deficient version of the mtDNA polymerase gamma (POLG), accumulate mtDNA mutations in multiple tis...

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Main Authors: Shinichi Someya, Gregory C Kujoth, Mi-Jung Kim, Timothy A Hacker, Marc Vermulst, Richard Weindruch, Tomas A Prolla
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2017-01-01
Series:PLoS ONE
Online Access:https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0171159&type=printable
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