Nanocrystalline cellulose-geniposide complex enhances gut-brain axis modulation for depression treatment
Abstract Depression, a major global health issue, is closely associated with imbalances in gut microbiota and altered intestinal functions. This study investigates the antidepressant potential of a composite of Geniposide (GP) and Nanocrystalline Cellulose (NCC), focusing on its effects on the gut-b...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2025-04-01
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| Series: | Communications Biology |
| Online Access: | https://doi.org/10.1038/s42003-025-07934-y |
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| author | Tianyu Zou Xiang Tang Haiping Wang Xiaolong Shang Xiaoyu Liang Xuemiao Ma |
| author_facet | Tianyu Zou Xiang Tang Haiping Wang Xiaolong Shang Xiaoyu Liang Xuemiao Ma |
| author_sort | Tianyu Zou |
| collection | DOAJ |
| description | Abstract Depression, a major global health issue, is closely associated with imbalances in gut microbiota and altered intestinal functions. This study investigates the antidepressant potential of a composite of Geniposide (GP) and Nanocrystalline Cellulose (NCC), focusing on its effects on the gut-brain axis. Utilizing network pharmacology, GP was identified as a key compound targeting the BCL2 gene in depression management. Experimental approaches, including a chronic unpredictable mild stress (CUMS) model in mice, cellular assays, and fecal microbiota transplantation (FMT), were used to evaluate the composite’s effectiveness. Results indicate that GP activates the adenosine monophosphate-activated protein kinase (AMPK) pathway by upregulating BCL2, enhancing intestinal barrier integrity, and balancing gut flora. These mechanisms contribute to its positive effects on hippocampal function and depressive-like behaviors in mice, suggesting that the GP-NCC composite could be a promising avenue for developing depression therapies that target gut health. |
| format | Article |
| id | doaj-art-d0ca796a0c4b49d6a740c35b50fc0150 |
| institution | OA Journals |
| issn | 2399-3642 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Communications Biology |
| spelling | doaj-art-d0ca796a0c4b49d6a740c35b50fc01502025-08-20T02:19:57ZengNature PortfolioCommunications Biology2399-36422025-04-018112210.1038/s42003-025-07934-yNanocrystalline cellulose-geniposide complex enhances gut-brain axis modulation for depression treatmentTianyu Zou0Xiang Tang1Haiping Wang2Xiaolong Shang3Xiaoyu Liang4Xuemiao Ma5Department of Encephalopathy, Shenzhen Luohu District Hospital of Traditional Chinese Medicine (Shenzhen Hospital of Shanghai University of Traditional Chinese Medicine)Department of Encephalopathy, Shenzhen Luohu District Hospital of Traditional Chinese Medicine (Shenzhen Hospital of Shanghai University of Traditional Chinese Medicine)Department of Encephalopathy, Shenzhen Luohu District Hospital of Traditional Chinese Medicine (Shenzhen Hospital of Shanghai University of Traditional Chinese Medicine)Department of Encephalopathy, Shenzhen Luohu District Hospital of Traditional Chinese Medicine (Shenzhen Hospital of Shanghai University of Traditional Chinese Medicine)Department of Encephalopathy, Shenzhen Luohu District Hospital of Traditional Chinese Medicine (Shenzhen Hospital of Shanghai University of Traditional Chinese Medicine)Department of Encephalopathy, Shenzhen Luohu District Hospital of Traditional Chinese Medicine (Shenzhen Hospital of Shanghai University of Traditional Chinese Medicine)Abstract Depression, a major global health issue, is closely associated with imbalances in gut microbiota and altered intestinal functions. This study investigates the antidepressant potential of a composite of Geniposide (GP) and Nanocrystalline Cellulose (NCC), focusing on its effects on the gut-brain axis. Utilizing network pharmacology, GP was identified as a key compound targeting the BCL2 gene in depression management. Experimental approaches, including a chronic unpredictable mild stress (CUMS) model in mice, cellular assays, and fecal microbiota transplantation (FMT), were used to evaluate the composite’s effectiveness. Results indicate that GP activates the adenosine monophosphate-activated protein kinase (AMPK) pathway by upregulating BCL2, enhancing intestinal barrier integrity, and balancing gut flora. These mechanisms contribute to its positive effects on hippocampal function and depressive-like behaviors in mice, suggesting that the GP-NCC composite could be a promising avenue for developing depression therapies that target gut health.https://doi.org/10.1038/s42003-025-07934-y |
| spellingShingle | Tianyu Zou Xiang Tang Haiping Wang Xiaolong Shang Xiaoyu Liang Xuemiao Ma Nanocrystalline cellulose-geniposide complex enhances gut-brain axis modulation for depression treatment Communications Biology |
| title | Nanocrystalline cellulose-geniposide complex enhances gut-brain axis modulation for depression treatment |
| title_full | Nanocrystalline cellulose-geniposide complex enhances gut-brain axis modulation for depression treatment |
| title_fullStr | Nanocrystalline cellulose-geniposide complex enhances gut-brain axis modulation for depression treatment |
| title_full_unstemmed | Nanocrystalline cellulose-geniposide complex enhances gut-brain axis modulation for depression treatment |
| title_short | Nanocrystalline cellulose-geniposide complex enhances gut-brain axis modulation for depression treatment |
| title_sort | nanocrystalline cellulose geniposide complex enhances gut brain axis modulation for depression treatment |
| url | https://doi.org/10.1038/s42003-025-07934-y |
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