Safety and efficacy of feed additives consisting of vitamin B2 (98%) and vitamin B2 (80%) produced with Bacillus subtilis CGMCC 7.449 for all animal species (Chifeng Pharmaceutical Co., Ltd.)
Abstract Following a request from the European Commission, the Panel on Additives and Products or Substances used in Animal Feed (FEEDAP) of EFSA was asked to deliver a scientific opinion on the safety and efficacy of vitamin B2 98% and vitamin B2 80% in the form of riboflavin produced by fermentati...
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| Format: | Article |
| Language: | English |
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Wiley
2025-02-01
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| Series: | EFSA Journal |
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| Online Access: | https://doi.org/10.2903/j.efsa.2025.9249 |
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| author | EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP) Roberto Edoardo Villa Giovanna Azimonti Eleftherios Bonos Henrik Christensen Mojca Durjava Birgit Dusemund Ronette Gehring Boet Glandorf Maryline Kouba Marta López‐Alonso Francesca Marcon Carlo Nebbia Alena Pechová Miguel Prieto‐Maradona Ilen Röhe Katerina Theodoridou Baltasar Mayo Nicole Bozzi Cionci Rosella Brozzi Jaume Galobart Orsolya Holczknecht Paola Manini Piera Valeri Maria Vittoria Vettori Fabiola Pizzo |
| author_facet | EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP) Roberto Edoardo Villa Giovanna Azimonti Eleftherios Bonos Henrik Christensen Mojca Durjava Birgit Dusemund Ronette Gehring Boet Glandorf Maryline Kouba Marta López‐Alonso Francesca Marcon Carlo Nebbia Alena Pechová Miguel Prieto‐Maradona Ilen Röhe Katerina Theodoridou Baltasar Mayo Nicole Bozzi Cionci Rosella Brozzi Jaume Galobart Orsolya Holczknecht Paola Manini Piera Valeri Maria Vittoria Vettori Fabiola Pizzo |
| author_sort | EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP) |
| collection | DOAJ |
| description | Abstract Following a request from the European Commission, the Panel on Additives and Products or Substances used in Animal Feed (FEEDAP) of EFSA was asked to deliver a scientific opinion on the safety and efficacy of vitamin B2 98% and vitamin B2 80% in the form of riboflavin produced by fermentation with a genetically modified strain of Bacillus subtilis (CGMCC 7.449) as nutritional feed additives for all animal species. Viable cells and DNA of the production strain were not detected in the final products and therefore, the use of B. subtilis CGMCC 7.449 to produce vitamin B2 does not raise safety concerns. The use of vitamin 98% and 80% produced with B. subtilis CGMCC 7.449 in animal nutrition does not represent a safety concern for the target species, consumers and for the environment. The additives are not dermal nor eye irritants but are dermal and respiratory sensitisers. Inhalation and dermal exposure are considered a risk. The additives under assessment are effective in covering the animals' requirements of vitamin B2 when administered via feed. |
| format | Article |
| id | doaj-art-d0c6ec3ee3e645ea9be3278ac7114d7e |
| institution | OA Journals |
| issn | 1831-4732 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Wiley |
| record_format | Article |
| series | EFSA Journal |
| spelling | doaj-art-d0c6ec3ee3e645ea9be3278ac7114d7e2025-08-20T02:26:04ZengWileyEFSA Journal1831-47322025-02-01232n/an/a10.2903/j.efsa.2025.9249Safety and efficacy of feed additives consisting of vitamin B2 (98%) and vitamin B2 (80%) produced with Bacillus subtilis CGMCC 7.449 for all animal species (Chifeng Pharmaceutical Co., Ltd.)EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP)Roberto Edoardo VillaGiovanna AzimontiEleftherios BonosHenrik ChristensenMojca DurjavaBirgit DusemundRonette GehringBoet GlandorfMaryline KoubaMarta López‐AlonsoFrancesca MarconCarlo NebbiaAlena PechováMiguel Prieto‐MaradonaIlen RöheKaterina TheodoridouBaltasar MayoNicole Bozzi CionciRosella BrozziJaume GalobartOrsolya HolczknechtPaola ManiniPiera ValeriMaria Vittoria VettoriFabiola PizzoAbstract Following a request from the European Commission, the Panel on Additives and Products or Substances used in Animal Feed (FEEDAP) of EFSA was asked to deliver a scientific opinion on the safety and efficacy of vitamin B2 98% and vitamin B2 80% in the form of riboflavin produced by fermentation with a genetically modified strain of Bacillus subtilis (CGMCC 7.449) as nutritional feed additives for all animal species. Viable cells and DNA of the production strain were not detected in the final products and therefore, the use of B. subtilis CGMCC 7.449 to produce vitamin B2 does not raise safety concerns. The use of vitamin 98% and 80% produced with B. subtilis CGMCC 7.449 in animal nutrition does not represent a safety concern for the target species, consumers and for the environment. The additives are not dermal nor eye irritants but are dermal and respiratory sensitisers. Inhalation and dermal exposure are considered a risk. The additives under assessment are effective in covering the animals' requirements of vitamin B2 when administered via feed.https://doi.org/10.2903/j.efsa.2025.9249all animal speciesefficacynutritional additivessafetyvitamin B2 |
| spellingShingle | EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP) Roberto Edoardo Villa Giovanna Azimonti Eleftherios Bonos Henrik Christensen Mojca Durjava Birgit Dusemund Ronette Gehring Boet Glandorf Maryline Kouba Marta López‐Alonso Francesca Marcon Carlo Nebbia Alena Pechová Miguel Prieto‐Maradona Ilen Röhe Katerina Theodoridou Baltasar Mayo Nicole Bozzi Cionci Rosella Brozzi Jaume Galobart Orsolya Holczknecht Paola Manini Piera Valeri Maria Vittoria Vettori Fabiola Pizzo Safety and efficacy of feed additives consisting of vitamin B2 (98%) and vitamin B2 (80%) produced with Bacillus subtilis CGMCC 7.449 for all animal species (Chifeng Pharmaceutical Co., Ltd.) EFSA Journal all animal species efficacy nutritional additives safety vitamin B2 |
| title | Safety and efficacy of feed additives consisting of vitamin B2 (98%) and vitamin B2 (80%) produced with Bacillus subtilis CGMCC 7.449 for all animal species (Chifeng Pharmaceutical Co., Ltd.) |
| title_full | Safety and efficacy of feed additives consisting of vitamin B2 (98%) and vitamin B2 (80%) produced with Bacillus subtilis CGMCC 7.449 for all animal species (Chifeng Pharmaceutical Co., Ltd.) |
| title_fullStr | Safety and efficacy of feed additives consisting of vitamin B2 (98%) and vitamin B2 (80%) produced with Bacillus subtilis CGMCC 7.449 for all animal species (Chifeng Pharmaceutical Co., Ltd.) |
| title_full_unstemmed | Safety and efficacy of feed additives consisting of vitamin B2 (98%) and vitamin B2 (80%) produced with Bacillus subtilis CGMCC 7.449 for all animal species (Chifeng Pharmaceutical Co., Ltd.) |
| title_short | Safety and efficacy of feed additives consisting of vitamin B2 (98%) and vitamin B2 (80%) produced with Bacillus subtilis CGMCC 7.449 for all animal species (Chifeng Pharmaceutical Co., Ltd.) |
| title_sort | safety and efficacy of feed additives consisting of vitamin b2 98 and vitamin b2 80 produced with bacillus subtilis cgmcc 7 449 for all animal species chifeng pharmaceutical co ltd |
| topic | all animal species efficacy nutritional additives safety vitamin B2 |
| url | https://doi.org/10.2903/j.efsa.2025.9249 |
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