Exploring research trends in cancer immunotherapy via single-cell technologies: a scientometric perspective
IntroductionCancer immunotherapy has brought new therapeutic hopes for cancer patients, but it is complex in its mechanism of action, and there are significant individual differences, which restricts its wide use. As single-cell analysis technology develops rapidly, it provides an innovative researc...
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Frontiers Media S.A.
2025-08-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2025.1640224/full |
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| author | Zhongxun Li Zhongxun Li Qi Han Qi Han Zimu Huang Sen Zhang Huina Guo Huina Guo Hongliang Liu Hongliang Liu Hongliang Liu Xiaoya Guan Xiaoya Guan Hairong Li Chunming Zhang Chunming Zhang Chunming Zhang |
| author_facet | Zhongxun Li Zhongxun Li Qi Han Qi Han Zimu Huang Sen Zhang Huina Guo Huina Guo Hongliang Liu Hongliang Liu Hongliang Liu Xiaoya Guan Xiaoya Guan Hairong Li Chunming Zhang Chunming Zhang Chunming Zhang |
| author_sort | Zhongxun Li |
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| description | IntroductionCancer immunotherapy has brought new therapeutic hopes for cancer patients, but it is complex in its mechanism of action, and there are significant individual differences, which restricts its wide use. As single-cell analysis technology develops rapidly, it provides an innovative research approach to investigate immunotherapy mechanisms, to identify potential biomarkers, and to optimize individualized treatment strategies.MethodsThe Core Collection of Web of Science (WOSCC) was used to retrieve and obtain relevant literature related to “application of single cell sequencing in cancer immunotherapy” since the establishment of the WOSCC. A quantitative analysis and visualization of the related literature was conducted using tools such as Bibliometrix, Excel, CiteSpace, VOSviewer, and Scimago Graphica.ResultsThe total number of related literatures included was 4856, with an average annual growth rate of 25.14%. According to published articles, China and the United States lead the field. Frontiers in immunology, Nature Communications, Journal for Immunotherapy of Cancer, Scientific Reports, Frontiers in Oncology and Cancers have an important academic influence in this field. Research hotspots focus on tumor immune microenvironment and cellular heterogeneity. Research trends such as spatial transcriptomics, standardized processes, and T cell function are becoming increasingly popular.ConclusionIn tumor immunotherapy, single-cell sequencing is profoundly changing the research paradigm. It not only improves our understanding of the immune microenvironment and therapeutic heterogeneity, but also assists us in identifying accurate markers and formulating individualized treatment plans. |
| format | Article |
| id | doaj-art-d0c52f80c5ac4a0eba15dbf768ca6db0 |
| institution | Kabale University |
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| language | English |
| publishDate | 2025-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj-art-d0c52f80c5ac4a0eba15dbf768ca6db02025-08-22T04:10:38ZengFrontiers Media S.A.Frontiers in Immunology1664-32242025-08-011610.3389/fimmu.2025.16402241640224Exploring research trends in cancer immunotherapy via single-cell technologies: a scientometric perspectiveZhongxun Li0Zhongxun Li1Qi Han2Qi Han3Zimu Huang4Sen Zhang5Huina Guo6Huina Guo7Hongliang Liu8Hongliang Liu9Hongliang Liu10Xiaoya Guan11Xiaoya Guan12Hairong Li13Chunming Zhang14Chunming Zhang15Chunming Zhang16Shanxi Key Laboratory of Otorhinolaryngology Head and Neck Cancer, First Hospital of Shanxi Medical University, Taiyuan, ChinaShanxi Province Clinical Medical Research Center for Precision Medicine of Head and Neck Cancer, First Hospital of Shanxi Medical University, Taiyuan, ChinaShanxi Key Laboratory of Otorhinolaryngology Head and Neck Cancer, First Hospital of Shanxi Medical University, Taiyuan, ChinaShanxi Province Clinical Medical Research Center for Precision Medicine of Head and Neck Cancer, First Hospital of Shanxi Medical University, Taiyuan, ChinaShanxi Medical University, Taiyuan, ChinaDepartment of Otolaryngology Head and Neck Surgery, First Hospital of Shanxi Medical University, Taiyuan, ChinaShanxi Key Laboratory of Otorhinolaryngology Head and Neck Cancer, First Hospital of Shanxi Medical University, Taiyuan, ChinaShanxi Province Clinical Medical Research Center for Precision Medicine of Head and Neck Cancer, First Hospital of Shanxi Medical University, Taiyuan, ChinaShanxi Key Laboratory of Otorhinolaryngology Head and Neck Cancer, First Hospital of Shanxi Medical University, Taiyuan, ChinaShanxi Province Clinical Medical Research Center for Precision Medicine of Head and Neck Cancer, First Hospital of Shanxi Medical University, Taiyuan, ChinaDepartment of Cell Biology and Genetics, The Basic Medical School of Shanxi Medical University, Taiyuan, Shanxi, ChinaShanxi Key Laboratory of Otorhinolaryngology Head and Neck Cancer, First Hospital of Shanxi Medical University, Taiyuan, ChinaShanxi Province Clinical Medical Research Center for Precision Medicine of Head and Neck Cancer, First Hospital of Shanxi Medical University, Taiyuan, ChinaDepartment of Histology and Embryology, Shanxi Medical University, Taiyuan, ChinaShanxi Key Laboratory of Otorhinolaryngology Head and Neck Cancer, First Hospital of Shanxi Medical University, Taiyuan, ChinaShanxi Province Clinical Medical Research Center for Precision Medicine of Head and Neck Cancer, First Hospital of Shanxi Medical University, Taiyuan, ChinaDepartment of Otolaryngology Head and Neck Surgery, First Hospital of Shanxi Medical University, Taiyuan, ChinaIntroductionCancer immunotherapy has brought new therapeutic hopes for cancer patients, but it is complex in its mechanism of action, and there are significant individual differences, which restricts its wide use. As single-cell analysis technology develops rapidly, it provides an innovative research approach to investigate immunotherapy mechanisms, to identify potential biomarkers, and to optimize individualized treatment strategies.MethodsThe Core Collection of Web of Science (WOSCC) was used to retrieve and obtain relevant literature related to “application of single cell sequencing in cancer immunotherapy” since the establishment of the WOSCC. A quantitative analysis and visualization of the related literature was conducted using tools such as Bibliometrix, Excel, CiteSpace, VOSviewer, and Scimago Graphica.ResultsThe total number of related literatures included was 4856, with an average annual growth rate of 25.14%. According to published articles, China and the United States lead the field. Frontiers in immunology, Nature Communications, Journal for Immunotherapy of Cancer, Scientific Reports, Frontiers in Oncology and Cancers have an important academic influence in this field. Research hotspots focus on tumor immune microenvironment and cellular heterogeneity. Research trends such as spatial transcriptomics, standardized processes, and T cell function are becoming increasingly popular.ConclusionIn tumor immunotherapy, single-cell sequencing is profoundly changing the research paradigm. It not only improves our understanding of the immune microenvironment and therapeutic heterogeneity, but also assists us in identifying accurate markers and formulating individualized treatment plans.https://www.frontiersin.org/articles/10.3389/fimmu.2025.1640224/fullimmunotherapytumor immune microenvironmentheterogeneitysingle-cell RNA sequencingbibliometrix |
| spellingShingle | Zhongxun Li Zhongxun Li Qi Han Qi Han Zimu Huang Sen Zhang Huina Guo Huina Guo Hongliang Liu Hongliang Liu Hongliang Liu Xiaoya Guan Xiaoya Guan Hairong Li Chunming Zhang Chunming Zhang Chunming Zhang Exploring research trends in cancer immunotherapy via single-cell technologies: a scientometric perspective Frontiers in Immunology immunotherapy tumor immune microenvironment heterogeneity single-cell RNA sequencing bibliometrix |
| title | Exploring research trends in cancer immunotherapy via single-cell technologies: a scientometric perspective |
| title_full | Exploring research trends in cancer immunotherapy via single-cell technologies: a scientometric perspective |
| title_fullStr | Exploring research trends in cancer immunotherapy via single-cell technologies: a scientometric perspective |
| title_full_unstemmed | Exploring research trends in cancer immunotherapy via single-cell technologies: a scientometric perspective |
| title_short | Exploring research trends in cancer immunotherapy via single-cell technologies: a scientometric perspective |
| title_sort | exploring research trends in cancer immunotherapy via single cell technologies a scientometric perspective |
| topic | immunotherapy tumor immune microenvironment heterogeneity single-cell RNA sequencing bibliometrix |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2025.1640224/full |
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