Causal relationships between dietary factors and spinal diseases: a univariable and multivariable Mendelian randomization study
BackgroundSpinal diseases and their associated symptoms are prevalent across all age groups, and their incidence severely affects countless individuals’ quality of life. The role of daily habits in the progression of these diseases is increasingly emphasized in research. Moreover, there are reports...
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Frontiers Media S.A.
2025-03-01
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| Series: | Frontiers in Nutrition |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnut.2025.1437484/full |
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| author | Yi-Qi Chen Yi-Qi Chen Zhen-Ya Chen Zhen-Ya Chen Zheng-Qi Song Zheng-Qi Song Hai-Bo Liang Hai-Bo Liang Yi-Jun Li Yi-Jun Li Hong Su Hong Su Hai-Ming Jin Hai-Ming Jin Xue-Qin Bai Xue-Qin Bai |
| author_facet | Yi-Qi Chen Yi-Qi Chen Zhen-Ya Chen Zhen-Ya Chen Zheng-Qi Song Zheng-Qi Song Hai-Bo Liang Hai-Bo Liang Yi-Jun Li Yi-Jun Li Hong Su Hong Su Hai-Ming Jin Hai-Ming Jin Xue-Qin Bai Xue-Qin Bai |
| author_sort | Yi-Qi Chen |
| collection | DOAJ |
| description | BackgroundSpinal diseases and their associated symptoms are prevalent across all age groups, and their incidence severely affects countless individuals’ quality of life. The role of daily habits in the progression of these diseases is increasingly emphasized in research. Moreover, there are reports suggesting associations between dietary factors and the onset of spinal diseases. However, the exact causal relationship between dietary factors and spinal diseases has not been fully elucidated.MethodsWe obtained GWAS data on 16 dietary intake and 187 dietary likings from the UK Biobank, and GWAS data on 23 types of spinal disorders from FinnGen R10. The analysis of causal effects was conducted using the Inverse Variance Weighted (IVW) test, and to ensure robustness, MR-Egger, Weighted median, and Bayesian weighted Mendelian randomization (BWMR) were utilized to validate the direction. Sensitivity analysis was conducted using the Cochran Q test and MR-Egger intercept test. Additionally, Multivariable MR (MVMR) was employed to examine the independent effect of alcohol intake frequency.ResultsIn summary, our study identified statistically significant causal associations between four dietary intake and 10 dietary linkings with various spinal disorders through univariable MR, with degenerative spinal changes showing the most significant dietary influence. Alcohol intake was identified as the primary risk factor, with other risk factors including poultry intake and likings for various types of meat. Protective factors mainly included intake and liking of fruits and vegetables. Additionally, various supplementary analytical methods along with heterogeneity and pleiotropy tests have confirmed the robustness of our results. To avoid the interference of diet-related diseases, multivariable MR analysis was conducted, showing that the incidence of cervical disc disorders may be influenced by gout, diabetes, and hypertension.ConclusionThis study indicates a potential causal relationship between dietary factors and the risk of spinal disorders, providing insights for the early detection and prevention. However, the specific pathogenic mechanisms require detailed basic and clinical research in the future. |
| format | Article |
| id | doaj-art-d0c3d65f012b465b803cffaf2e5427a7 |
| institution | DOAJ |
| issn | 2296-861X |
| language | English |
| publishDate | 2025-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Nutrition |
| spelling | doaj-art-d0c3d65f012b465b803cffaf2e5427a72025-08-20T02:57:32ZengFrontiers Media S.A.Frontiers in Nutrition2296-861X2025-03-011210.3389/fnut.2025.14374841437484Causal relationships between dietary factors and spinal diseases: a univariable and multivariable Mendelian randomization studyYi-Qi Chen0Yi-Qi Chen1Zhen-Ya Chen2Zhen-Ya Chen3Zheng-Qi Song4Zheng-Qi Song5Hai-Bo Liang6Hai-Bo Liang7Yi-Jun Li8Yi-Jun Li9Hong Su10Hong Su11Hai-Ming Jin12Hai-Ming Jin13Xue-Qin Bai14Xue-Qin Bai15Department of Radiology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, ChinaThe Second Clinical Medical College, Wenzhou Medical University, Wenzhou, Zhejiang, ChinaDepartment of Radiology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, ChinaThe Second Clinical Medical College, Wenzhou Medical University, Wenzhou, Zhejiang, ChinaDepartment of Radiology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, ChinaThe First Clinical Medical College, Wenzhou Medical University, Wenzhou, Zhejiang, ChinaThe Second Clinical Medical College, Wenzhou Medical University, Wenzhou, Zhejiang, ChinaDepartment of Orthopaedics, The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical University, Wenzhou, ChinaDepartment of Radiology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, ChinaThe First Clinical Medical College, Wenzhou Medical University, Wenzhou, Zhejiang, ChinaThe Second Clinical Medical College, Wenzhou Medical University, Wenzhou, Zhejiang, ChinaDepartment of Orthopaedics, The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical University, Wenzhou, ChinaThe Second Clinical Medical College, Wenzhou Medical University, Wenzhou, Zhejiang, ChinaDepartment of Orthopaedics, The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical University, Wenzhou, ChinaDepartment of Radiology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, ChinaThe First Clinical Medical College, Wenzhou Medical University, Wenzhou, Zhejiang, ChinaBackgroundSpinal diseases and their associated symptoms are prevalent across all age groups, and their incidence severely affects countless individuals’ quality of life. The role of daily habits in the progression of these diseases is increasingly emphasized in research. Moreover, there are reports suggesting associations between dietary factors and the onset of spinal diseases. However, the exact causal relationship between dietary factors and spinal diseases has not been fully elucidated.MethodsWe obtained GWAS data on 16 dietary intake and 187 dietary likings from the UK Biobank, and GWAS data on 23 types of spinal disorders from FinnGen R10. The analysis of causal effects was conducted using the Inverse Variance Weighted (IVW) test, and to ensure robustness, MR-Egger, Weighted median, and Bayesian weighted Mendelian randomization (BWMR) were utilized to validate the direction. Sensitivity analysis was conducted using the Cochran Q test and MR-Egger intercept test. Additionally, Multivariable MR (MVMR) was employed to examine the independent effect of alcohol intake frequency.ResultsIn summary, our study identified statistically significant causal associations between four dietary intake and 10 dietary linkings with various spinal disorders through univariable MR, with degenerative spinal changes showing the most significant dietary influence. Alcohol intake was identified as the primary risk factor, with other risk factors including poultry intake and likings for various types of meat. Protective factors mainly included intake and liking of fruits and vegetables. Additionally, various supplementary analytical methods along with heterogeneity and pleiotropy tests have confirmed the robustness of our results. To avoid the interference of diet-related diseases, multivariable MR analysis was conducted, showing that the incidence of cervical disc disorders may be influenced by gout, diabetes, and hypertension.ConclusionThis study indicates a potential causal relationship between dietary factors and the risk of spinal disorders, providing insights for the early detection and prevention. However, the specific pathogenic mechanisms require detailed basic and clinical research in the future.https://www.frontiersin.org/articles/10.3389/fnut.2025.1437484/fullspinal diseasesdegenerative spinal diseasesfood likingfood intakeMendelian randomization |
| spellingShingle | Yi-Qi Chen Yi-Qi Chen Zhen-Ya Chen Zhen-Ya Chen Zheng-Qi Song Zheng-Qi Song Hai-Bo Liang Hai-Bo Liang Yi-Jun Li Yi-Jun Li Hong Su Hong Su Hai-Ming Jin Hai-Ming Jin Xue-Qin Bai Xue-Qin Bai Causal relationships between dietary factors and spinal diseases: a univariable and multivariable Mendelian randomization study Frontiers in Nutrition spinal diseases degenerative spinal diseases food liking food intake Mendelian randomization |
| title | Causal relationships between dietary factors and spinal diseases: a univariable and multivariable Mendelian randomization study |
| title_full | Causal relationships between dietary factors and spinal diseases: a univariable and multivariable Mendelian randomization study |
| title_fullStr | Causal relationships between dietary factors and spinal diseases: a univariable and multivariable Mendelian randomization study |
| title_full_unstemmed | Causal relationships between dietary factors and spinal diseases: a univariable and multivariable Mendelian randomization study |
| title_short | Causal relationships between dietary factors and spinal diseases: a univariable and multivariable Mendelian randomization study |
| title_sort | causal relationships between dietary factors and spinal diseases a univariable and multivariable mendelian randomization study |
| topic | spinal diseases degenerative spinal diseases food liking food intake Mendelian randomization |
| url | https://www.frontiersin.org/articles/10.3389/fnut.2025.1437484/full |
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