The single-cell atlas of short-chain fatty acid receptors in human and mice hearts
IntroductionThe gut microbiota metabolite, short-chain fatty acids (SCFAs), can protect against multiple cardiovascular diseases, while the molecular targets and underlying mechanisms need to be elucidated. One of the primary mechanisms of SCFA benefits was the direct activation of a group of G-prot...
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Frontiers Media S.A.
2025-04-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2025.1538384/full |
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| author | Xiaojun He Xiaojun He Qiang Wang Qiang Long Yiming Zhong Zhaoxi Qi Yecen Zhang Lan Chang Bei Qian Shixing Huang Xinming Wang Xuemei Chen Feifei Li Xiaomei Yang Xiaomei Yang Xiaomei Yang Wei Dong Gao Zhizhao Song Li Xu Qiang Zhao |
| author_facet | Xiaojun He Xiaojun He Qiang Wang Qiang Long Yiming Zhong Zhaoxi Qi Yecen Zhang Lan Chang Bei Qian Shixing Huang Xinming Wang Xuemei Chen Feifei Li Xiaomei Yang Xiaomei Yang Xiaomei Yang Wei Dong Gao Zhizhao Song Li Xu Qiang Zhao |
| author_sort | Xiaojun He |
| collection | DOAJ |
| description | IntroductionThe gut microbiota metabolite, short-chain fatty acids (SCFAs), can protect against multiple cardiovascular diseases, while the molecular targets and underlying mechanisms need to be elucidated. One of the primary mechanisms of SCFA benefits was the direct activation of a group of G-protein-coupled receptors (GPCRs), termed free fatty acid receptors (FFARs), the FFAR2 (GPR43), and FFAR3 (GPR41). At present, the distribution of FFAR2/3 in cardiac cells has not been entirely clarified.MethodsUsing 18 public single-cell RNA-seq and single-nuclear RNA-seq data of human and mouse hearts, we illustrate the entire atlas of FFAR2/3 distribution in different regions and cell types in normal and infarcted hearts.Results and discussionWe present the atlas of FFAR2/3 in the whole human body, normal and infarcted hearts at single-cell resolution. We also illustrated the entire atlas of FFAR2/3 in normal/ischemic hearts of newborn and adult mice by combining public and newly built sc/snRNA-seq datasets. These findings provide valuable information on the possible effect of SCFAs via FFAR2/3 in the heart and valuable references for future studies. |
| format | Article |
| id | doaj-art-d0c080c585ac4bbdba24f667612defff |
| institution | OA Journals |
| issn | 1664-3224 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj-art-d0c080c585ac4bbdba24f667612defff2025-08-20T02:26:36ZengFrontiers Media S.A.Frontiers in Immunology1664-32242025-04-011610.3389/fimmu.2025.15383841538384The single-cell atlas of short-chain fatty acid receptors in human and mice heartsXiaojun He0Xiaojun He1Qiang Wang2Qiang Long3Yiming Zhong4Zhaoxi Qi5Yecen Zhang6Lan Chang7Bei Qian8Shixing Huang9Xinming Wang10Xuemei Chen11Feifei Li12Xiaomei Yang13Xiaomei Yang14Xiaomei Yang15Wei Dong Gao16Zhizhao Song17Li Xu18Qiang Zhao19Cardiovascular Medical Center, Department of Cardiovascular Surgery, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, ChinaDepartment of Cardiovascular Surgery, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, ChinaCardiovascular Medical Center, Department of Cardiovascular Surgery, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, ChinaDepartment of Cardiovascular Surgery, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, ChinaDepartment of Cardiovascular Surgery, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, ChinaDepartment of Cardiovascular Surgery, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, ChinaDepartment of Cardiovascular Surgery, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, ChinaDepartment of Cardiovascular Surgery, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, ChinaDepartment of Cardiovascular Surgery, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, ChinaDepartment of Cardiovascular Surgery, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, ChinaDepartment of Cardiovascular Surgery, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, ChinaDepartment of Anesthesiology, Shanghai Tenth People’s Hospital, Tongji University School of Medicine, Shanghai, ChinaDepartment of Cardiology, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, ChinaDepartment of Anesthesiology, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan, ChinaSchool of Medicine, Cheeloo College of Medicine, Shandong University, Jinan, ChinaDepartment of Cardiology, Johns Hopkins School of Medicine, Baltimore, MD, United StatesDepartment of Anesthesiology and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, United StatesCardiovascular Medical Center, Department of Cardiovascular Surgery, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, ChinaClinical Trial Institution, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, Jiangsu, ChinaDepartment of Cardiovascular Surgery, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, ChinaIntroductionThe gut microbiota metabolite, short-chain fatty acids (SCFAs), can protect against multiple cardiovascular diseases, while the molecular targets and underlying mechanisms need to be elucidated. One of the primary mechanisms of SCFA benefits was the direct activation of a group of G-protein-coupled receptors (GPCRs), termed free fatty acid receptors (FFARs), the FFAR2 (GPR43), and FFAR3 (GPR41). At present, the distribution of FFAR2/3 in cardiac cells has not been entirely clarified.MethodsUsing 18 public single-cell RNA-seq and single-nuclear RNA-seq data of human and mouse hearts, we illustrate the entire atlas of FFAR2/3 distribution in different regions and cell types in normal and infarcted hearts.Results and discussionWe present the atlas of FFAR2/3 in the whole human body, normal and infarcted hearts at single-cell resolution. We also illustrated the entire atlas of FFAR2/3 in normal/ischemic hearts of newborn and adult mice by combining public and newly built sc/snRNA-seq datasets. These findings provide valuable information on the possible effect of SCFAs via FFAR2/3 in the heart and valuable references for future studies.https://www.frontiersin.org/articles/10.3389/fimmu.2025.1538384/fullFFAR2FFAR3single-cell atlashearthumanmice |
| spellingShingle | Xiaojun He Xiaojun He Qiang Wang Qiang Long Yiming Zhong Zhaoxi Qi Yecen Zhang Lan Chang Bei Qian Shixing Huang Xinming Wang Xuemei Chen Feifei Li Xiaomei Yang Xiaomei Yang Xiaomei Yang Wei Dong Gao Zhizhao Song Li Xu Qiang Zhao The single-cell atlas of short-chain fatty acid receptors in human and mice hearts Frontiers in Immunology FFAR2 FFAR3 single-cell atlas heart human mice |
| title | The single-cell atlas of short-chain fatty acid receptors in human and mice hearts |
| title_full | The single-cell atlas of short-chain fatty acid receptors in human and mice hearts |
| title_fullStr | The single-cell atlas of short-chain fatty acid receptors in human and mice hearts |
| title_full_unstemmed | The single-cell atlas of short-chain fatty acid receptors in human and mice hearts |
| title_short | The single-cell atlas of short-chain fatty acid receptors in human and mice hearts |
| title_sort | single cell atlas of short chain fatty acid receptors in human and mice hearts |
| topic | FFAR2 FFAR3 single-cell atlas heart human mice |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2025.1538384/full |
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