Beyond the Beat: Understanding Inherited Risk and Therapeutic Opportunities in Cardiovascular Diseases with Emphasis on Inherited Cardiomyopathies and Inherited Arrhythmic Syndromes
Over the past three decades, significant progress has been made in elucidating the intricate connection between genetic predispositions and cardiovascular diseases (CVDs). Through extensive investigation, numerous genetic variants linked to various cardiovascular conditions have been discovered, she...
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| Format: | Article |
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MDPI AG
2024-09-01
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| Series: | Cardiogenetics |
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| Online Access: | https://www.mdpi.com/2035-8148/14/3/12 |
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| author | Antea Krsek Lara Baticic Vlatka Sotosek |
| author_facet | Antea Krsek Lara Baticic Vlatka Sotosek |
| author_sort | Antea Krsek |
| collection | DOAJ |
| description | Over the past three decades, significant progress has been made in elucidating the intricate connection between genetic predispositions and cardiovascular diseases (CVDs). Through extensive investigation, numerous genetic variants linked to various cardiovascular conditions have been discovered, shedding crucial light on the underlying biological mechanisms and pathways. These discoveries have not only revolutionized risk assessment for patients but have also paved the way for personalized treatment strategies, allowing healthcare providers to tailor interventions according to individual genetic profiles. Furthermore, genetic testing has facilitated cascade screening, enabling the early identification and intervention of potential cardiovascular issues among at-risk biological family members. This review aims to comprehensively summarize the current state of knowledge regarding inherited risk and novel insights from human genome and epigenome research, as well as therapeutic opportunities in CVDs with special emphasis on inherited cardiomyopathies and inherited arrhythmic syndromes. The newest translational trials for CVDs and pharmaceutical approaches are discussed, including gene therapy options for heart failure and cardiomyopathies. |
| format | Article |
| id | doaj-art-d0bfab709dae443b8538c64ccc4b5fb4 |
| institution | OA Journals |
| issn | 2035-8253 2035-8148 |
| language | English |
| publishDate | 2024-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cardiogenetics |
| spelling | doaj-art-d0bfab709dae443b8538c64ccc4b5fb42025-08-20T01:55:27ZengMDPI AGCardiogenetics2035-82532035-81482024-09-0114314916910.3390/cardiogenetics14030012Beyond the Beat: Understanding Inherited Risk and Therapeutic Opportunities in Cardiovascular Diseases with Emphasis on Inherited Cardiomyopathies and Inherited Arrhythmic SyndromesAntea Krsek0Lara Baticic1Vlatka Sotosek2Faculty of Medicine, University of Rijeka, 51000 Rijeka, CroatiaDepartment of Medical Chemistry, Biochemistry and Clinical Chemistry, Faculty of Medicine, University of Rijeka, 51000 Rijeka, CroatiaDepartment of Clinical Medical Sciences I, Faculty of Health Studies, University of Rijeka, 51000 Rijeka, CroatiaOver the past three decades, significant progress has been made in elucidating the intricate connection between genetic predispositions and cardiovascular diseases (CVDs). Through extensive investigation, numerous genetic variants linked to various cardiovascular conditions have been discovered, shedding crucial light on the underlying biological mechanisms and pathways. These discoveries have not only revolutionized risk assessment for patients but have also paved the way for personalized treatment strategies, allowing healthcare providers to tailor interventions according to individual genetic profiles. Furthermore, genetic testing has facilitated cascade screening, enabling the early identification and intervention of potential cardiovascular issues among at-risk biological family members. This review aims to comprehensively summarize the current state of knowledge regarding inherited risk and novel insights from human genome and epigenome research, as well as therapeutic opportunities in CVDs with special emphasis on inherited cardiomyopathies and inherited arrhythmic syndromes. The newest translational trials for CVDs and pharmaceutical approaches are discussed, including gene therapy options for heart failure and cardiomyopathies.https://www.mdpi.com/2035-8148/14/3/12cardiomyopathiescardiovascular diseaseshypertrophic cardiomyopathyinherited riskprimary arrhythmic disorders |
| spellingShingle | Antea Krsek Lara Baticic Vlatka Sotosek Beyond the Beat: Understanding Inherited Risk and Therapeutic Opportunities in Cardiovascular Diseases with Emphasis on Inherited Cardiomyopathies and Inherited Arrhythmic Syndromes Cardiogenetics cardiomyopathies cardiovascular diseases hypertrophic cardiomyopathy inherited risk primary arrhythmic disorders |
| title | Beyond the Beat: Understanding Inherited Risk and Therapeutic Opportunities in Cardiovascular Diseases with Emphasis on Inherited Cardiomyopathies and Inherited Arrhythmic Syndromes |
| title_full | Beyond the Beat: Understanding Inherited Risk and Therapeutic Opportunities in Cardiovascular Diseases with Emphasis on Inherited Cardiomyopathies and Inherited Arrhythmic Syndromes |
| title_fullStr | Beyond the Beat: Understanding Inherited Risk and Therapeutic Opportunities in Cardiovascular Diseases with Emphasis on Inherited Cardiomyopathies and Inherited Arrhythmic Syndromes |
| title_full_unstemmed | Beyond the Beat: Understanding Inherited Risk and Therapeutic Opportunities in Cardiovascular Diseases with Emphasis on Inherited Cardiomyopathies and Inherited Arrhythmic Syndromes |
| title_short | Beyond the Beat: Understanding Inherited Risk and Therapeutic Opportunities in Cardiovascular Diseases with Emphasis on Inherited Cardiomyopathies and Inherited Arrhythmic Syndromes |
| title_sort | beyond the beat understanding inherited risk and therapeutic opportunities in cardiovascular diseases with emphasis on inherited cardiomyopathies and inherited arrhythmic syndromes |
| topic | cardiomyopathies cardiovascular diseases hypertrophic cardiomyopathy inherited risk primary arrhythmic disorders |
| url | https://www.mdpi.com/2035-8148/14/3/12 |
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