Effect of N-Acetylcysteine on Dyslipidemia and Carbohydrate Metabolism in STZ-Induced Diabetic Rats
Background. Type 1 diabetes mellitus (T1DM) is characterized by insulin-deficient production leading to hyperglycemia, which is associated with diabetic complications such as cardiovascular diseases. Antioxidants have been proving a good alternative to diabetic complications, with N-acetylcysteine (...
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Wiley
2018-01-01
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| Series: | International Journal of Vascular Medicine |
| Online Access: | http://dx.doi.org/10.1155/2018/6428630 |
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| author | Anderson Kiyoshi Kaga Pedro Octavio Barbanera Nágilla Orleanne Lima do Carmo Lucas Rodolfo de Oliveira Rosa Ana Angélica Henrique Fernandes |
| author_facet | Anderson Kiyoshi Kaga Pedro Octavio Barbanera Nágilla Orleanne Lima do Carmo Lucas Rodolfo de Oliveira Rosa Ana Angélica Henrique Fernandes |
| author_sort | Anderson Kiyoshi Kaga |
| collection | DOAJ |
| description | Background. Type 1 diabetes mellitus (T1DM) is characterized by insulin-deficient production leading to hyperglycemia, which is associated with diabetic complications such as cardiovascular diseases. Antioxidants have been proving a good alternative to diabetic complications, with N-acetylcysteine (NAC) having antioxidant characteristics. The aim of this study was to assess the effect of NAC on the lipid profile and the atherogenic index (AI) in streptozotocin- (STZ-) induced diabetic rats. Method. 32 male Wistar rats (60 days of age) weighting ±250 g were randomly distributed into four groups (n=8): CTRL: control rats; CTRL+NAC: control rats treated with NAC; DM: diabetic rats; DM+NAC: diabetic rats treated with NAC. T1DM was induced using STZ (60 mg/kg, ip; single dose), and NAC (25 mg/kg/day) was administrated by gavage, for 37 days. The animals received chow and water ad libitum. After the experimental period, blood and cardiac tissue samples were collected to analyze energetic metabolism, lipid profile, and AI. Results. NAC decreased (p<0.01) glycemia, energy intake, carbohydrate, and protein consumption in diabetic rats (DM+NAC), when compared with DM, while the alimentary efficiency was improved (p<0.01) in treated diabetic rats (DM+NAC). Diabetic rats treated with NAC decreased (p<0.01) lipid profile and AI in diabetic rats (DM+NAC) when compared to DM. Conclusion. NAC improves lipid profile and decreases AI in STZ-induced diabetic rats. |
| format | Article |
| id | doaj-art-d0a718f0f82646fd82ae782c144a2752 |
| institution | Kabale University |
| issn | 2090-2824 2090-2832 |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Vascular Medicine |
| spelling | doaj-art-d0a718f0f82646fd82ae782c144a27522025-02-03T01:20:47ZengWileyInternational Journal of Vascular Medicine2090-28242090-28322018-01-01201810.1155/2018/64286306428630Effect of N-Acetylcysteine on Dyslipidemia and Carbohydrate Metabolism in STZ-Induced Diabetic RatsAnderson Kiyoshi Kaga0Pedro Octavio Barbanera1Nágilla Orleanne Lima do Carmo2Lucas Rodolfo de Oliveira Rosa3Ana Angélica Henrique Fernandes4Department of Chemistry and Biochemistry, Institute of Biosciences of Botucatu, Sao Paulo State University (UNESP), Rua Professor Doutor Antônio Celso Wagner Zanin s/n, Distrito de Rubião Júnior, 18618-689 Botucatu, SP, BrazilDepartment of Chemistry and Biochemistry, Institute of Biosciences of Botucatu, Sao Paulo State University (UNESP), Rua Professor Doutor Antônio Celso Wagner Zanin s/n, Distrito de Rubião Júnior, 18618-689 Botucatu, SP, BrazilDepartment of Chemistry and Biochemistry, Institute of Biosciences of Botucatu, Sao Paulo State University (UNESP), Rua Professor Doutor Antônio Celso Wagner Zanin s/n, Distrito de Rubião Júnior, 18618-689 Botucatu, SP, BrazilDepartment of Chemistry and Biochemistry, Institute of Biosciences of Botucatu, Sao Paulo State University (UNESP), Rua Professor Doutor Antônio Celso Wagner Zanin s/n, Distrito de Rubião Júnior, 18618-689 Botucatu, SP, BrazilDepartment of Chemistry and Biochemistry, Institute of Biosciences of Botucatu, Sao Paulo State University (UNESP), Rua Professor Doutor Antônio Celso Wagner Zanin s/n, Distrito de Rubião Júnior, 18618-689 Botucatu, SP, BrazilBackground. Type 1 diabetes mellitus (T1DM) is characterized by insulin-deficient production leading to hyperglycemia, which is associated with diabetic complications such as cardiovascular diseases. Antioxidants have been proving a good alternative to diabetic complications, with N-acetylcysteine (NAC) having antioxidant characteristics. The aim of this study was to assess the effect of NAC on the lipid profile and the atherogenic index (AI) in streptozotocin- (STZ-) induced diabetic rats. Method. 32 male Wistar rats (60 days of age) weighting ±250 g were randomly distributed into four groups (n=8): CTRL: control rats; CTRL+NAC: control rats treated with NAC; DM: diabetic rats; DM+NAC: diabetic rats treated with NAC. T1DM was induced using STZ (60 mg/kg, ip; single dose), and NAC (25 mg/kg/day) was administrated by gavage, for 37 days. The animals received chow and water ad libitum. After the experimental period, blood and cardiac tissue samples were collected to analyze energetic metabolism, lipid profile, and AI. Results. NAC decreased (p<0.01) glycemia, energy intake, carbohydrate, and protein consumption in diabetic rats (DM+NAC), when compared with DM, while the alimentary efficiency was improved (p<0.01) in treated diabetic rats (DM+NAC). Diabetic rats treated with NAC decreased (p<0.01) lipid profile and AI in diabetic rats (DM+NAC) when compared to DM. Conclusion. NAC improves lipid profile and decreases AI in STZ-induced diabetic rats.http://dx.doi.org/10.1155/2018/6428630 |
| spellingShingle | Anderson Kiyoshi Kaga Pedro Octavio Barbanera Nágilla Orleanne Lima do Carmo Lucas Rodolfo de Oliveira Rosa Ana Angélica Henrique Fernandes Effect of N-Acetylcysteine on Dyslipidemia and Carbohydrate Metabolism in STZ-Induced Diabetic Rats International Journal of Vascular Medicine |
| title | Effect of N-Acetylcysteine on Dyslipidemia and Carbohydrate Metabolism in STZ-Induced Diabetic Rats |
| title_full | Effect of N-Acetylcysteine on Dyslipidemia and Carbohydrate Metabolism in STZ-Induced Diabetic Rats |
| title_fullStr | Effect of N-Acetylcysteine on Dyslipidemia and Carbohydrate Metabolism in STZ-Induced Diabetic Rats |
| title_full_unstemmed | Effect of N-Acetylcysteine on Dyslipidemia and Carbohydrate Metabolism in STZ-Induced Diabetic Rats |
| title_short | Effect of N-Acetylcysteine on Dyslipidemia and Carbohydrate Metabolism in STZ-Induced Diabetic Rats |
| title_sort | effect of n acetylcysteine on dyslipidemia and carbohydrate metabolism in stz induced diabetic rats |
| url | http://dx.doi.org/10.1155/2018/6428630 |
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