Prognostic stratification of patients with AJCC 2018 pN1 disease in stage III oral squamous cell carcinoma
Abstract Background Oral cancer with pT1-3N1 without extracapsular extension of the lymph node is classified as stage III according to the eighth edition of the AJCC staging system. Outcomes of a subgroup of patients classified as having stage III oral cancer with single nodal metastasis are observe...
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SAGE Publishing
2022-04-01
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| Series: | Journal of Otolaryngology - Head and Neck Surgery |
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| Online Access: | https://doi.org/10.1186/s40463-022-00573-x |
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| author | Ming-Hsien Tsai Hui-Ching Chuang Yu-Tsai Lin Tai-Lin Huang Fu-Min Fang Hui Lu Chih-Yen Chien |
| author_facet | Ming-Hsien Tsai Hui-Ching Chuang Yu-Tsai Lin Tai-Lin Huang Fu-Min Fang Hui Lu Chih-Yen Chien |
| author_sort | Ming-Hsien Tsai |
| collection | DOAJ |
| description | Abstract Background Oral cancer with pT1-3N1 without extracapsular extension of the lymph node is classified as stage III according to the eighth edition of the AJCC staging system. Outcomes of a subgroup of patients classified as having stage III oral cancer with single nodal metastasis are observed to be various clinically. Therefore, such clinical outcomes for subgroup analyses in this cohort are necessary. Methods Patients with pT1-3N1 (based on the eighth edition of the AJCC staging system) oral cancer who underwent surgery between 2007 and 2016 were enrolled retrospectively for survival analyses. Results A total of 105 patients—including 28 patients with pT1N1 disease and 77 patients with pT2-3N1 disease—participated in the study. Pathological T classification was the only statistically significant prognosticator according to univariate analysis. The patients with pT1N1 disease showed better 5-year overall survival (OS), disease specific survival (DSS), and disease free survival (DFS) than those with pT2-3N1 disease (pT1N1 vs pT2-3N1, OS: 96.4% vs 72.2%, p = 0.004; DSS: 96.4% vs 77.3%, p = 0.021; DFS: 84.6% vs 62.3%, p = 0.023). Besides, there was no potential clinicopathological confounder which is significant associated with different pathological T classifications in this unique cohort. Conclusions Patients in the pT1N1 subgroup have significantly favorable prognosis than those with pT2-3N1 disease. Down-staging and reclassifying pT1N1 subgroup patients with oral cancer may be considered in tumor staging. Graphical Abstract |
| format | Article |
| id | doaj-art-d0a69c79a382467aa281729648db76a1 |
| institution | Kabale University |
| issn | 1916-0216 |
| language | English |
| publishDate | 2022-04-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Journal of Otolaryngology - Head and Neck Surgery |
| spelling | doaj-art-d0a69c79a382467aa281729648db76a12025-02-03T00:22:57ZengSAGE PublishingJournal of Otolaryngology - Head and Neck Surgery1916-02162022-04-015111810.1186/s40463-022-00573-xPrognostic stratification of patients with AJCC 2018 pN1 disease in stage III oral squamous cell carcinomaMing-Hsien Tsai0Hui-Ching Chuang1Yu-Tsai Lin2Tai-Lin Huang3Fu-Min Fang4Hui Lu5Chih-Yen Chien6Department of Otolaryngology, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of MedicineDepartment of Otolaryngology, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of MedicineDepartment of Otolaryngology, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of MedicineKaohsiung Chang Gung Head and Neck Oncology Group, Cancer Center, Kaohsiung Chang Gung Memorial HospitalKaohsiung Chang Gung Head and Neck Oncology Group, Cancer Center, Kaohsiung Chang Gung Memorial HospitalDepartment of Otolaryngology, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of MedicineDepartment of Otolaryngology, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of MedicineAbstract Background Oral cancer with pT1-3N1 without extracapsular extension of the lymph node is classified as stage III according to the eighth edition of the AJCC staging system. Outcomes of a subgroup of patients classified as having stage III oral cancer with single nodal metastasis are observed to be various clinically. Therefore, such clinical outcomes for subgroup analyses in this cohort are necessary. Methods Patients with pT1-3N1 (based on the eighth edition of the AJCC staging system) oral cancer who underwent surgery between 2007 and 2016 were enrolled retrospectively for survival analyses. Results A total of 105 patients—including 28 patients with pT1N1 disease and 77 patients with pT2-3N1 disease—participated in the study. Pathological T classification was the only statistically significant prognosticator according to univariate analysis. The patients with pT1N1 disease showed better 5-year overall survival (OS), disease specific survival (DSS), and disease free survival (DFS) than those with pT2-3N1 disease (pT1N1 vs pT2-3N1, OS: 96.4% vs 72.2%, p = 0.004; DSS: 96.4% vs 77.3%, p = 0.021; DFS: 84.6% vs 62.3%, p = 0.023). Besides, there was no potential clinicopathological confounder which is significant associated with different pathological T classifications in this unique cohort. Conclusions Patients in the pT1N1 subgroup have significantly favorable prognosis than those with pT2-3N1 disease. Down-staging and reclassifying pT1N1 subgroup patients with oral cancer may be considered in tumor staging. Graphical Abstracthttps://doi.org/10.1186/s40463-022-00573-xSingle nodal metastasisN1Stage IIIOral cancerPrognosis |
| spellingShingle | Ming-Hsien Tsai Hui-Ching Chuang Yu-Tsai Lin Tai-Lin Huang Fu-Min Fang Hui Lu Chih-Yen Chien Prognostic stratification of patients with AJCC 2018 pN1 disease in stage III oral squamous cell carcinoma Journal of Otolaryngology - Head and Neck Surgery Single nodal metastasis N1 Stage III Oral cancer Prognosis |
| title | Prognostic stratification of patients with AJCC 2018 pN1 disease in stage III oral squamous cell carcinoma |
| title_full | Prognostic stratification of patients with AJCC 2018 pN1 disease in stage III oral squamous cell carcinoma |
| title_fullStr | Prognostic stratification of patients with AJCC 2018 pN1 disease in stage III oral squamous cell carcinoma |
| title_full_unstemmed | Prognostic stratification of patients with AJCC 2018 pN1 disease in stage III oral squamous cell carcinoma |
| title_short | Prognostic stratification of patients with AJCC 2018 pN1 disease in stage III oral squamous cell carcinoma |
| title_sort | prognostic stratification of patients with ajcc 2018 pn1 disease in stage iii oral squamous cell carcinoma |
| topic | Single nodal metastasis N1 Stage III Oral cancer Prognosis |
| url | https://doi.org/10.1186/s40463-022-00573-x |
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