Collagen Scaffolds in Bone Sialoprotein-Mediated Bone Regeneration
Decades of research in bioengineering have resulted in the development of many types of 3-dimentional (3D) scaffolds for use as drug delivery systems (DDS) and for tissue regeneration. Scaffolds may be comprised of different natural fibers and synthetic polymers as well as ceramics in order to exert...
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Wiley
2013-01-01
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| Series: | The Scientific World Journal |
| Online Access: | http://dx.doi.org/10.1155/2013/812718 |
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| author | Thomas E. Kruger Andrew H. Miller Jinxi Wang |
| author_facet | Thomas E. Kruger Andrew H. Miller Jinxi Wang |
| author_sort | Thomas E. Kruger |
| collection | DOAJ |
| description | Decades of research in bioengineering have resulted in the development of many types of 3-dimentional (3D) scaffolds for use as drug delivery systems (DDS) and for tissue regeneration. Scaffolds may be comprised of different natural fibers and synthetic polymers as well as ceramics in order to exert the most beneficial attributes including biocompatibility, biodegradability, structural integrity, cell infiltration and attachment, and neovascularization. Type I collagen scaffolds meet most of these criteria. In addition, type I collagen binds integrins through RGD and non-RGD sites which facilitates cell migration, attachment, and proliferation. Type I collagen scaffolds can be used for bone tissue repair when they are coated with osteogenic proteins such as bone morphogenic protein (BMP) and bone sialoprotein (BSP). BSP, a small integrin-binding ligand N-linked glycoprotein (SIBLING), has osteogenic properties and plays an essential role in bone formation. BSP also mediates mineral deposition, binds type I collagen with high affinity, and binds αvβ3 and αvβ5 integrins which mediate cell signaling. This paper reviews the emerging evidence demonstrating the efficacy of BSP-collagen scaffolds in bone regeneration. |
| format | Article |
| id | doaj-art-d0a1b3c80da34cbf84da6ed9906d8a06 |
| institution | DOAJ |
| issn | 1537-744X |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | The Scientific World Journal |
| spelling | doaj-art-d0a1b3c80da34cbf84da6ed9906d8a062025-08-20T03:19:35ZengWileyThe Scientific World Journal1537-744X2013-01-01201310.1155/2013/812718812718Collagen Scaffolds in Bone Sialoprotein-Mediated Bone RegenerationThomas E. Kruger0Andrew H. Miller1Jinxi Wang2Harrington Laboratory for Molecular Orthopedics, Department of Orthopedic Surgery, University of Kansas Medical Center, Kansas City, KS 66160, USAHarrington Laboratory for Molecular Orthopedics, Department of Orthopedic Surgery, University of Kansas Medical Center, Kansas City, KS 66160, USAHarrington Laboratory for Molecular Orthopedics, Department of Orthopedic Surgery, University of Kansas Medical Center, Kansas City, KS 66160, USADecades of research in bioengineering have resulted in the development of many types of 3-dimentional (3D) scaffolds for use as drug delivery systems (DDS) and for tissue regeneration. Scaffolds may be comprised of different natural fibers and synthetic polymers as well as ceramics in order to exert the most beneficial attributes including biocompatibility, biodegradability, structural integrity, cell infiltration and attachment, and neovascularization. Type I collagen scaffolds meet most of these criteria. In addition, type I collagen binds integrins through RGD and non-RGD sites which facilitates cell migration, attachment, and proliferation. Type I collagen scaffolds can be used for bone tissue repair when they are coated with osteogenic proteins such as bone morphogenic protein (BMP) and bone sialoprotein (BSP). BSP, a small integrin-binding ligand N-linked glycoprotein (SIBLING), has osteogenic properties and plays an essential role in bone formation. BSP also mediates mineral deposition, binds type I collagen with high affinity, and binds αvβ3 and αvβ5 integrins which mediate cell signaling. This paper reviews the emerging evidence demonstrating the efficacy of BSP-collagen scaffolds in bone regeneration.http://dx.doi.org/10.1155/2013/812718 |
| spellingShingle | Thomas E. Kruger Andrew H. Miller Jinxi Wang Collagen Scaffolds in Bone Sialoprotein-Mediated Bone Regeneration The Scientific World Journal |
| title | Collagen Scaffolds in Bone Sialoprotein-Mediated Bone Regeneration |
| title_full | Collagen Scaffolds in Bone Sialoprotein-Mediated Bone Regeneration |
| title_fullStr | Collagen Scaffolds in Bone Sialoprotein-Mediated Bone Regeneration |
| title_full_unstemmed | Collagen Scaffolds in Bone Sialoprotein-Mediated Bone Regeneration |
| title_short | Collagen Scaffolds in Bone Sialoprotein-Mediated Bone Regeneration |
| title_sort | collagen scaffolds in bone sialoprotein mediated bone regeneration |
| url | http://dx.doi.org/10.1155/2013/812718 |
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