White Globe Appearance–Like Findings Indicating Intralymphatic Cancer Involvement Beneath the Epithelium in Gastric Cancer
A 75-year-old female was diagnosed with a type 0-I, moderately differentiated, early gastric carcinoma on the posterior wall of the middle gastric body during esophagogastroduodenoscopy (EGD). Several small whitish structures, referred to as white globe appearances (WGAs), were noted on the oral sid...
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| Format: | Article |
| Language: | English |
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Wiley
2024-01-01
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| Series: | Case Reports in Gastrointestinal Medicine |
| Online Access: | http://dx.doi.org/10.1155/2024/8504987 |
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| author | Hiroki Maruyama Taku Yamagata Yoshihide Kanno Takeshi Shimizu Takuho Itasaka Fumiyoshi Fujishima Takashi Sawai Kei Ito |
| author_facet | Hiroki Maruyama Taku Yamagata Yoshihide Kanno Takeshi Shimizu Takuho Itasaka Fumiyoshi Fujishima Takashi Sawai Kei Ito |
| author_sort | Hiroki Maruyama |
| collection | DOAJ |
| description | A 75-year-old female was diagnosed with a type 0-I, moderately differentiated, early gastric carcinoma on the posterior wall of the middle gastric body during esophagogastroduodenoscopy (EGD). Several small whitish structures, referred to as white globe appearances (WGAs), were noted on the oral side outside the demarcation line of the cancerous protrusion. Although this area was flat without cancerous mucosal changes on the surface, subepithelial cancer extension was suspected. The histopathology of the resected specimen revealed that the carcinoma with submucosal invasion had significant lymphatic invasion with submucosal lateral extent along lymphatic vessels. In some areas, the carcinoma within the lymphatic vessels regressed from the submucosal layer towards the mucosal lamina propria, penetrating the muscularis mucosas. The intralymphatic carcinoma reaching just beneath the epithelium was considered to manifest WGA features during endoscopy. |
| format | Article |
| id | doaj-art-d09ba32a0ae5480fbc613d8da1d2878f |
| institution | OA Journals |
| issn | 2090-6536 |
| language | English |
| publishDate | 2024-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Gastrointestinal Medicine |
| spelling | doaj-art-d09ba32a0ae5480fbc613d8da1d2878f2025-08-20T02:20:05ZengWileyCase Reports in Gastrointestinal Medicine2090-65362024-01-01202410.1155/2024/8504987White Globe Appearance–Like Findings Indicating Intralymphatic Cancer Involvement Beneath the Epithelium in Gastric CancerHiroki Maruyama0Taku Yamagata1Yoshihide Kanno2Takeshi Shimizu3Takuho Itasaka4Fumiyoshi Fujishima5Takashi Sawai6Kei Ito7Department of GastroenterologyDepartment of GastroenterologyDepartment of GastroenterologyDepartment of GastroenterologyDepartment of GastroenterologyDepartment of PathologyDepartment of PathologyDepartment of GastroenterologyA 75-year-old female was diagnosed with a type 0-I, moderately differentiated, early gastric carcinoma on the posterior wall of the middle gastric body during esophagogastroduodenoscopy (EGD). Several small whitish structures, referred to as white globe appearances (WGAs), were noted on the oral side outside the demarcation line of the cancerous protrusion. Although this area was flat without cancerous mucosal changes on the surface, subepithelial cancer extension was suspected. The histopathology of the resected specimen revealed that the carcinoma with submucosal invasion had significant lymphatic invasion with submucosal lateral extent along lymphatic vessels. In some areas, the carcinoma within the lymphatic vessels regressed from the submucosal layer towards the mucosal lamina propria, penetrating the muscularis mucosas. The intralymphatic carcinoma reaching just beneath the epithelium was considered to manifest WGA features during endoscopy.http://dx.doi.org/10.1155/2024/8504987 |
| spellingShingle | Hiroki Maruyama Taku Yamagata Yoshihide Kanno Takeshi Shimizu Takuho Itasaka Fumiyoshi Fujishima Takashi Sawai Kei Ito White Globe Appearance–Like Findings Indicating Intralymphatic Cancer Involvement Beneath the Epithelium in Gastric Cancer Case Reports in Gastrointestinal Medicine |
| title | White Globe Appearance–Like Findings Indicating Intralymphatic Cancer Involvement Beneath the Epithelium in Gastric Cancer |
| title_full | White Globe Appearance–Like Findings Indicating Intralymphatic Cancer Involvement Beneath the Epithelium in Gastric Cancer |
| title_fullStr | White Globe Appearance–Like Findings Indicating Intralymphatic Cancer Involvement Beneath the Epithelium in Gastric Cancer |
| title_full_unstemmed | White Globe Appearance–Like Findings Indicating Intralymphatic Cancer Involvement Beneath the Epithelium in Gastric Cancer |
| title_short | White Globe Appearance–Like Findings Indicating Intralymphatic Cancer Involvement Beneath the Epithelium in Gastric Cancer |
| title_sort | white globe appearance like findings indicating intralymphatic cancer involvement beneath the epithelium in gastric cancer |
| url | http://dx.doi.org/10.1155/2024/8504987 |
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