Risk factors for unplanned weaning of continuous renal replacement therapy in ICU patients: a meta-analysis
Objective To systematically review the risk factors for unplanned weaning during continuous renal replacement therapy in ICU patients.Methods A combination of subject words + free words was used to search the relevant literature published in CNKI, Wanfang, VIP, CBM, PubMed, EMbase, Web of Science, C...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2024-12-01
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| Series: | Renal Failure |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/0886022X.2024.2387431 |
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| author | Zhi Zeng Yuqi Shen Li Wan Xiuru Yang Zhenghua Liang Mei He |
| author_facet | Zhi Zeng Yuqi Shen Li Wan Xiuru Yang Zhenghua Liang Mei He |
| author_sort | Zhi Zeng |
| collection | DOAJ |
| description | Objective To systematically review the risk factors for unplanned weaning during continuous renal replacement therapy in ICU patients.Methods A combination of subject words + free words was used to search the relevant literature published in CNKI, Wanfang, VIP, CBM, PubMed, EMbase, Web of Science, Cochrane Library, Mediline and other databases. The search period was from the establishment of the databases to June 25, 2024. Revman 5.4 software and Stata15.0 software was used to meta-analyze the risk factors for unplanned weaning during continuous renal replacement therapy in ICU patients.Results A total of 23 studies were included in this meta-analysis, describing 15 variables, 3793 patients, and using 7197 filters. Meta-analysis results showed that risk factors for unplanned weaning during continuous renal replacement therapy in ICU patients were as follows: Low mean arterial pressure [OR = 1.02, 95%CI (1.00, 1.03), p < 0.05], hypothermia [OR = 3.40, 95%CI (1.78, 6.47), p < 0.05], age (≥60 years) [OR = 4.45, 95%CI (3.18, 6.22), p < 0.05], comorbid underlying disease [OR = 3.63, 95%CI (2.70, 4.88), p < 0.05], agitation [OR = 4.97, 95%CI (3.20, 7.74), p < 0.05], no anticoagulant use [OR = 1.65, 95%CI (1.25, 2.17), p < 0.05], short activated partial prothrombin time [OR = 1.23, 95%CI (1.13, 1.34), p < 0.05], hyper-hematocrit [OR = 1.73, 95%CI (1.13, 2.66), p = 0.01], low ionized calcium concentration [OR = 1.48, 95% CI (1.08, 2.02), p = 0.01], CRRT that was treated at a high dose [OR = 1.42, 95%CI (1.14, 1.76), p < 0.05], mechanical ventilation [OR = 4.25, 95%CI (2.67, 6.77), p < 0.05], and lack of dedicated care [OR = 5.08, 95%CI (2.51, 10.28), p < 0.05]. However, it is unclear whether platelet count, prothrombin activity, and blood flow velocity are risk factors for unplanned weaning during CRRT in ICU patients, and more studies are needed for further validation.Conclusion Available evidence suggests that a variety of factors contribute to unplanned weaning of CRRT in ICU patients. Early detection of these risk factors is essential for healthcare professionals to develop preventive and curative strategies.Registration This study is registered on the PROSERO website under registration number CRD42024543554. |
| format | Article |
| id | doaj-art-d09327aecec34d56b7e1ec8e268a2e41 |
| institution | DOAJ |
| issn | 0886-022X 1525-6049 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Renal Failure |
| spelling | doaj-art-d09327aecec34d56b7e1ec8e268a2e412025-08-20T03:12:51ZengTaylor & Francis GroupRenal Failure0886-022X1525-60492024-12-0146210.1080/0886022X.2024.2387431Risk factors for unplanned weaning of continuous renal replacement therapy in ICU patients: a meta-analysisZhi Zeng0Yuqi Shen1Li Wan2Xiuru Yang3Zhenghua Liang4Mei He5Intensive Care Unit, Mianyang Central Hospital, School of Medicine, University of Electronic Science and Technology of China, Mianyang, Sichuan Province, ChinaIntensive Care Unit, Mianyang Central Hospital, School of Medicine, University of Electronic Science and Technology of China, Mianyang, Sichuan Province, ChinaIntensive Care Unit, Mianyang Central Hospital, School of Medicine, University of Electronic Science and Technology of China, Mianyang, Sichuan Province, ChinaIntensive Care Unit, Mianyang Central Hospital, School of Medicine, University of Electronic Science and Technology of China, Mianyang, Sichuan Province, ChinaIntensive Care Unit, Mianyang Central Hospital, School of Medicine, University of Electronic Science and Technology of China, Mianyang, Sichuan Province, ChinaIntensive Care Unit, Mianyang Central Hospital, School of Medicine, University of Electronic Science and Technology of China, Mianyang, Sichuan Province, ChinaObjective To systematically review the risk factors for unplanned weaning during continuous renal replacement therapy in ICU patients.Methods A combination of subject words + free words was used to search the relevant literature published in CNKI, Wanfang, VIP, CBM, PubMed, EMbase, Web of Science, Cochrane Library, Mediline and other databases. The search period was from the establishment of the databases to June 25, 2024. Revman 5.4 software and Stata15.0 software was used to meta-analyze the risk factors for unplanned weaning during continuous renal replacement therapy in ICU patients.Results A total of 23 studies were included in this meta-analysis, describing 15 variables, 3793 patients, and using 7197 filters. Meta-analysis results showed that risk factors for unplanned weaning during continuous renal replacement therapy in ICU patients were as follows: Low mean arterial pressure [OR = 1.02, 95%CI (1.00, 1.03), p < 0.05], hypothermia [OR = 3.40, 95%CI (1.78, 6.47), p < 0.05], age (≥60 years) [OR = 4.45, 95%CI (3.18, 6.22), p < 0.05], comorbid underlying disease [OR = 3.63, 95%CI (2.70, 4.88), p < 0.05], agitation [OR = 4.97, 95%CI (3.20, 7.74), p < 0.05], no anticoagulant use [OR = 1.65, 95%CI (1.25, 2.17), p < 0.05], short activated partial prothrombin time [OR = 1.23, 95%CI (1.13, 1.34), p < 0.05], hyper-hematocrit [OR = 1.73, 95%CI (1.13, 2.66), p = 0.01], low ionized calcium concentration [OR = 1.48, 95% CI (1.08, 2.02), p = 0.01], CRRT that was treated at a high dose [OR = 1.42, 95%CI (1.14, 1.76), p < 0.05], mechanical ventilation [OR = 4.25, 95%CI (2.67, 6.77), p < 0.05], and lack of dedicated care [OR = 5.08, 95%CI (2.51, 10.28), p < 0.05]. However, it is unclear whether platelet count, prothrombin activity, and blood flow velocity are risk factors for unplanned weaning during CRRT in ICU patients, and more studies are needed for further validation.Conclusion Available evidence suggests that a variety of factors contribute to unplanned weaning of CRRT in ICU patients. Early detection of these risk factors is essential for healthcare professionals to develop preventive and curative strategies.Registration This study is registered on the PROSERO website under registration number CRD42024543554.https://www.tandfonline.com/doi/10.1080/0886022X.2024.2387431Intensive care unitcontinuous renal replacement therapyunplanned weaningrisk factorsmeta-analysis |
| spellingShingle | Zhi Zeng Yuqi Shen Li Wan Xiuru Yang Zhenghua Liang Mei He Risk factors for unplanned weaning of continuous renal replacement therapy in ICU patients: a meta-analysis Renal Failure Intensive care unit continuous renal replacement therapy unplanned weaning risk factors meta-analysis |
| title | Risk factors for unplanned weaning of continuous renal replacement therapy in ICU patients: a meta-analysis |
| title_full | Risk factors for unplanned weaning of continuous renal replacement therapy in ICU patients: a meta-analysis |
| title_fullStr | Risk factors for unplanned weaning of continuous renal replacement therapy in ICU patients: a meta-analysis |
| title_full_unstemmed | Risk factors for unplanned weaning of continuous renal replacement therapy in ICU patients: a meta-analysis |
| title_short | Risk factors for unplanned weaning of continuous renal replacement therapy in ICU patients: a meta-analysis |
| title_sort | risk factors for unplanned weaning of continuous renal replacement therapy in icu patients a meta analysis |
| topic | Intensive care unit continuous renal replacement therapy unplanned weaning risk factors meta-analysis |
| url | https://www.tandfonline.com/doi/10.1080/0886022X.2024.2387431 |
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