Association Between Serum Afamin Levels with Nonalcoholic Associated Fatty Liver Disease
Afamin is a member of the hepatokine that are strongly associated with various metabolic diseases. The relationship between afamin and nonalcoholic fatty liver disease (NAFLD) remains unclear. This study aimed to explore the correlation between serum afamin levels and NAFLD. We analyzed 88 NAFLD pat...
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| Format: | Article |
| Language: | English |
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Wiley
2022-01-01
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| Series: | Canadian Journal of Gastroenterology and Hepatology |
| Online Access: | http://dx.doi.org/10.1155/2022/7175108 |
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| _version_ | 1849695454101504000 |
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| author | Shenghui Chen Zhening Liu Li Cen Jinghua Wang Juanwen Zhang Xiaofeng Zhang Chengfu Xu |
| author_facet | Shenghui Chen Zhening Liu Li Cen Jinghua Wang Juanwen Zhang Xiaofeng Zhang Chengfu Xu |
| author_sort | Shenghui Chen |
| collection | DOAJ |
| description | Afamin is a member of the hepatokine that are strongly associated with various metabolic diseases. The relationship between afamin and nonalcoholic fatty liver disease (NAFLD) remains unclear. This study aimed to explore the correlation between serum afamin levels and NAFLD. We analyzed 88 NAFLD patients and 88 age- and sex-matched healthy controls who took their health examinations at the First Affiliated Hospital, Zhejiang University School of Medicine. The association was further confirmed in 22 biopsy-confirmed NAFLD patients and 36 healthy controls. Serum afamin levels were evaluated using an enzyme-linked immunosorbent assay (ELISA). NAFLD patients had significantly higher serum afamin levels than the healthy controls (14.79 ± 5.04 mg/L versus 10.83 ± 3.24 mg/L; P<0.001). Serum afamin levels were positively correlated with metabolic parameters including the body mass index, waist circumference, systolic blood pressure, liver enzymes, and lipid profiles. A multiple regression analysis showed that serum afamin levels were independently related to the risk of NAFLD (OR: 1.289, 95% CI, 1.141–1.456; P<0.001). The receiver operating characteristic (ROC) analysis showed that the area under curve (AUC) of serum afamin plus the BMI for detecting NAFLD was 0.878. In participants with liver biopsies, the serum afamin plus the BMI detected NAFLD with an AUC of 0.758. In conclusion, serum afamin levels were positively associated with prevalence and risk of NAFLD, and serum afamin plus the BMI had a high diagnostic performance for NAFLD. This study provides epidemiological evidence of afamin in NAFLD. |
| format | Article |
| id | doaj-art-d08d4b80b02c4d8d8f9f137e2e4ccf19 |
| institution | DOAJ |
| issn | 2291-2797 |
| language | English |
| publishDate | 2022-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Canadian Journal of Gastroenterology and Hepatology |
| spelling | doaj-art-d08d4b80b02c4d8d8f9f137e2e4ccf192025-08-20T03:19:46ZengWileyCanadian Journal of Gastroenterology and Hepatology2291-27972022-01-01202210.1155/2022/7175108Association Between Serum Afamin Levels with Nonalcoholic Associated Fatty Liver DiseaseShenghui Chen0Zhening Liu1Li Cen2Jinghua Wang3Juanwen Zhang4Xiaofeng Zhang5Chengfu Xu6GastroenterologyGastroenterologyGastroenterologyGastroenterologyDepartment of Laboratory MedicineGastroenterologyGastroenterologyAfamin is a member of the hepatokine that are strongly associated with various metabolic diseases. The relationship between afamin and nonalcoholic fatty liver disease (NAFLD) remains unclear. This study aimed to explore the correlation between serum afamin levels and NAFLD. We analyzed 88 NAFLD patients and 88 age- and sex-matched healthy controls who took their health examinations at the First Affiliated Hospital, Zhejiang University School of Medicine. The association was further confirmed in 22 biopsy-confirmed NAFLD patients and 36 healthy controls. Serum afamin levels were evaluated using an enzyme-linked immunosorbent assay (ELISA). NAFLD patients had significantly higher serum afamin levels than the healthy controls (14.79 ± 5.04 mg/L versus 10.83 ± 3.24 mg/L; P<0.001). Serum afamin levels were positively correlated with metabolic parameters including the body mass index, waist circumference, systolic blood pressure, liver enzymes, and lipid profiles. A multiple regression analysis showed that serum afamin levels were independently related to the risk of NAFLD (OR: 1.289, 95% CI, 1.141–1.456; P<0.001). The receiver operating characteristic (ROC) analysis showed that the area under curve (AUC) of serum afamin plus the BMI for detecting NAFLD was 0.878. In participants with liver biopsies, the serum afamin plus the BMI detected NAFLD with an AUC of 0.758. In conclusion, serum afamin levels were positively associated with prevalence and risk of NAFLD, and serum afamin plus the BMI had a high diagnostic performance for NAFLD. This study provides epidemiological evidence of afamin in NAFLD.http://dx.doi.org/10.1155/2022/7175108 |
| spellingShingle | Shenghui Chen Zhening Liu Li Cen Jinghua Wang Juanwen Zhang Xiaofeng Zhang Chengfu Xu Association Between Serum Afamin Levels with Nonalcoholic Associated Fatty Liver Disease Canadian Journal of Gastroenterology and Hepatology |
| title | Association Between Serum Afamin Levels with Nonalcoholic Associated Fatty Liver Disease |
| title_full | Association Between Serum Afamin Levels with Nonalcoholic Associated Fatty Liver Disease |
| title_fullStr | Association Between Serum Afamin Levels with Nonalcoholic Associated Fatty Liver Disease |
| title_full_unstemmed | Association Between Serum Afamin Levels with Nonalcoholic Associated Fatty Liver Disease |
| title_short | Association Between Serum Afamin Levels with Nonalcoholic Associated Fatty Liver Disease |
| title_sort | association between serum afamin levels with nonalcoholic associated fatty liver disease |
| url | http://dx.doi.org/10.1155/2022/7175108 |
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