Toxicity of ubiquitous tire rubber antiozonant N-(1,3-dimethylbutyl)-N′-phenyl-p-phenylenediamine (6PPD) and its transformation product 6PPD-quinone (6PPD-Q) in primary human hepatocytes and liver spheroids

Toxicity of ubiquitous tire rubber antiozonant N-(1,3-dimethylbutyl)-N′-phenyl-p-phenylenediamine (6PPD) and its transformation product 6PPD-quinone (6PPD-Q) in primary human hepatocytes and liver spheroids

The tire rubber antioxidant N-(1,3-dimethylbutyl)-N′-phenyl-p-phenylenediamine (6PPD) and its oxidation product 6PPD-quinone (6PPD-Q) were recently found in human bodies. Though 6PPD/6PPD-Q showed species-dependent toxicity in animals, human relevant data are scarce. Here, primary human hepatocytes...

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Bibliographic Details
Main Authors: Daniel J. Yeisley, Lijun Ren, Katy S. Papineau, Laura K. Schnackenberg, Gonçalo Gamboa da Costa, Tucker A. Patterson, Suzanne C. Fitzpatrick, Qiang Shi
Format: Article
Language:English
Published: Elsevier 2025-09-01
Series:Biochemistry and Biophysics Reports
Subjects:
6PPD
6PPD-Q
Primary human hepatocytes
Liver injury
Spheroids
Online Access:http://www.sciencedirect.com/science/article/pii/S2405580825002869
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