Metabolic Syndrome in Caucasian Women with Hyperandrogenism: Lipid Metabolism and Lipid Peroxidation System
Background: The study aimed to evaluate the parameters of lipid metabolism and lipid peroxidation (LPO) - antioxidant defense (AOD) system disorders in Caucasian women with metabolic syndrome (MetS) and hyperandrogenism (HA). Methods and Results: 300 Caucasian women of reproductive age (18-44 years...
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| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
International Medical Research and Development Corporation
2025-03-01
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| Series: | International Journal of Biomedicine |
| Subjects: | |
| Online Access: | http://www.ijbm.org/articles/i57/ijbm_15(1)_oa5.pdf |
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| Summary: | Background: The study aimed to evaluate the parameters of lipid metabolism and lipid peroxidation (LPO) - antioxidant defense (AOD) system disorders in Caucasian women with metabolic syndrome (MetS) and hyperandrogenism (HA).
Methods and Results: 300 Caucasian women of reproductive age (18-44 years) living in the Irkutsk region and the Republic of Buryatia territories were examined. According to MetS and polycystic ovary syndrome (PCOS) diagnostic criteria, the following groups were formed: Group 1 included 209 women with MetS, and Group 2 included 23 women with MetS and PCOS (hyperandrogenic phenotypes). The control group (n=68) consisted of practically healthy women.
The parameters of lipid metabolism (triglycerides [TG], low-density lipoprotein cholesterol [LDL-C], high-density lipoprotein cholesterol [HDL-C]), lipid peroxidation system (double bounds [DBs], conjugated dienes [CDs], ketodienes and conjugated trienes [KD and CT], thiobarbituric acids reactive substances [TBARS]), and antioxidant defense (total antioxidant activity [TAA], superoxide dismutase [SOD] activity, reduced glutathione [GSH], oxidized glutathione [GSSG], retinol, α-tocopherol) were studied. Spectrophotometric, fluorometric, and statistic methods were used.
In Group 1 (MetS), the levels of TG and LDL-C were significantly higher than in the control group (P<0.0001 and P=0.046, respectively). In contrast, the HDL-C level was significantly lower than in the control group (P<0001). Similarly, in Group 2 (MetS+HA), we found an increase in the TG level (P<0.001) and a decrease in the HDL-C level (P=0.008) compared with the control group. (Table 1). There were no differences between Groups 1 and 2 (P>0.05).
The LPO reactions were more intense in women with MetS, characterized by a higher content of substrates with DBs (P=0.010) and TBARS (P=0.037) compared with the control group. In Group 2 (MetS+HA), only the TBARS level was statistically significantly higher (P=0.008) than in the control group.
In Group 1 (MetS), the SOD activity and the levels of α-tocopherol and retinol were significantly higher than in the control group (P=0.005, P=0.017, and P<0.001, respectively) (Table 3). The SOD activity was significantly lower in Group 2 (MetS+HA) than in Group 1 (MetS) (P=0.043). The remaining indicators of antioxidant defense status did not differ significantly between Groups 1 and 2.
Conclusion: The data obtained indicated a proatherogenic nature of lipid metabolism, increased LPO reactions, and a compensatory increase in some components of the AOD system in Caucasian women with MetS. In women with the MetS-HA comorbidity, the activity of AOD factors does not increase. |
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| ISSN: | 2158-0510 2158-0529 |