Ranking mAb–excipient interactions in biologics formulations by NMR spectroscopy and computational approaches

Ranking mAb–excipient interactions in biologics formulations by NMR spectroscopy and computational approaches

Excipients are added to biopharmaceutical formulations to enhance protein stability and enable the development of robust formulations with acceptable physicochemical properties, but the mechanism by which they confer stability is not fully understood. Here, we aimed to elucidate the mechanism throug...

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Bibliographic Details
Main Authors: Chunting Zhang, Steven T. Gossert, Jonathan Williams, Michael Little, Marilia Barros, Barton Dear, Bradley Falk, Ankit D. Kanthe, Robert Garmise, Luciano Mueller, Andrew Ilott, Anuji Abraham
Format: Article
Language:English
Published: Taylor & Francis Group 2023-12-01
Series:mAbs
Subjects:
Excipient ranking
mab stability
mab–excipient interaction
molecular dynamics
Monte carlo
STD NMR
Online Access:https://www.tandfonline.com/doi/10.1080/19420862.2023.2212416
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