Comparison of growth hormone therapy response according to the presence of growth hormone deficiency in children born small for gestational age with short stature in Korea: a retrospective cohort study
Abstract Background This study aimed to compare the response to growth hormone (GH) therapy according to the presence of GH deficiency (GHD) in short-stature children born small for gestational age (SGA) in Korea and to present appropriate GH dose criteria. Methods We evaluated 27 children born SGA...
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BMC
2025-02-01
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| Series: | BMC Pediatrics |
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| Online Access: | https://doi.org/10.1186/s12887-024-05339-0 |
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| author | Ha Young Jo Hyun Ji Jang Chong Kun Cheon Ju Young Yoon Sukdong Yoo Jung Hyun Lee Jeong Eun Lee Ye Jin Kim Sejin Kim Hyun-Ji Kim Im Jeong Choi Min Jung Kwak |
| author_facet | Ha Young Jo Hyun Ji Jang Chong Kun Cheon Ju Young Yoon Sukdong Yoo Jung Hyun Lee Jeong Eun Lee Ye Jin Kim Sejin Kim Hyun-Ji Kim Im Jeong Choi Min Jung Kwak |
| author_sort | Ha Young Jo |
| collection | DOAJ |
| description | Abstract Background This study aimed to compare the response to growth hormone (GH) therapy according to the presence of GH deficiency (GHD) in short-stature children born small for gestational age (SGA) in Korea and to present appropriate GH dose criteria. Methods We evaluated 27 children born SGA with short stature and GHD (GHD group) and 23 without GHD (non-GHD group) registered in the LG Growth Study. Growth responses and changes in GH dose over a 2-year GH therapy period were compared, and the factors affecting growth response were investigated. Results The standard deviation scores (SDSs) for baseline weight and body mass index (BMI) were significantly lower in boys without GHD than in boys with GHD. The SDS for insulin-like growth factor-1 (IGF-1) was lower among boys without GHD than among boys with GHD, while the SDS for insulin-like growth factor-binding protein-3 (IGFBP-3) was higher among girls without GHD than among girls with GHD; however, there was no significant difference when comparing all children with GHD to those without GHD. Regardless of the presence of GHD, the difference between chronological age and bone age decreased annually. Notably, there was significantly rapid bone age progression among patients without GHD. The findings showed differences in GH dose according to GHD starting from the 2nd year of therapy, with the non-GHD group receiving a significantly higher dose. Regarding the factors affecting growth response, younger age and bone age, higher height SDS, BMI SDS and MPH SDS were related to higher growth response (Δheight SDS and Δgrowth velocity), but there was no statistically significant correlation. Conclusion GHD is rare among children born SGA. Nonetheless, if there are any signs of decreased growth velocity or hypopituitarism, the presence of GHD should be assessed before GH therapy, and personalized therapy based on the results is required. |
| format | Article |
| id | doaj-art-d07f41aeb6d54b2d9342dbdd391c33a5 |
| institution | Kabale University |
| issn | 1471-2431 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Pediatrics |
| spelling | doaj-art-d07f41aeb6d54b2d9342dbdd391c33a52025-02-02T12:42:52ZengBMCBMC Pediatrics1471-24312025-02-012511810.1186/s12887-024-05339-0Comparison of growth hormone therapy response according to the presence of growth hormone deficiency in children born small for gestational age with short stature in Korea: a retrospective cohort studyHa Young Jo0Hyun Ji Jang1Chong Kun Cheon2Ju Young Yoon3Sukdong Yoo4Jung Hyun Lee5Jeong Eun Lee6Ye Jin Kim7Sejin Kim8Hyun-Ji Kim9Im Jeong Choi10Min Jung Kwak11Department of Pediatrics, Pusan National University School of MedicineDepartment of Pediatrics, Good Moonhwa HospitalDepartment of Pediatrics, Pusan National University School of MedicineDepartment of Pediatrics, Pusan National University School of MedicineDepartment of Pediatrics, Pusan National University School of MedicineDepartment of Pediatrics, Kosin University Gospel HospitalDepartment of Pediatrics, Inje University Busan Paik HospitalDepartment of Pediatrics, Inje University Haeundae Paik HospitalDepartment of Pediatrics, Keimyung University Dongsan HospitalDepartment of Pediatrics, Ilsin Christian HospitalDepartment of Pediatrics, Mirae Children’s HospitalDepartment of Pediatrics, Haeundae Bumin HospitalAbstract Background This study aimed to compare the response to growth hormone (GH) therapy according to the presence of GH deficiency (GHD) in short-stature children born small for gestational age (SGA) in Korea and to present appropriate GH dose criteria. Methods We evaluated 27 children born SGA with short stature and GHD (GHD group) and 23 without GHD (non-GHD group) registered in the LG Growth Study. Growth responses and changes in GH dose over a 2-year GH therapy period were compared, and the factors affecting growth response were investigated. Results The standard deviation scores (SDSs) for baseline weight and body mass index (BMI) were significantly lower in boys without GHD than in boys with GHD. The SDS for insulin-like growth factor-1 (IGF-1) was lower among boys without GHD than among boys with GHD, while the SDS for insulin-like growth factor-binding protein-3 (IGFBP-3) was higher among girls without GHD than among girls with GHD; however, there was no significant difference when comparing all children with GHD to those without GHD. Regardless of the presence of GHD, the difference between chronological age and bone age decreased annually. Notably, there was significantly rapid bone age progression among patients without GHD. The findings showed differences in GH dose according to GHD starting from the 2nd year of therapy, with the non-GHD group receiving a significantly higher dose. Regarding the factors affecting growth response, younger age and bone age, higher height SDS, BMI SDS and MPH SDS were related to higher growth response (Δheight SDS and Δgrowth velocity), but there was no statistically significant correlation. Conclusion GHD is rare among children born SGA. Nonetheless, if there are any signs of decreased growth velocity or hypopituitarism, the presence of GHD should be assessed before GH therapy, and personalized therapy based on the results is required.https://doi.org/10.1186/s12887-024-05339-0Small for gestational ageGrowth hormone deficiencyHuman growth hormoneGrowth disorderChild |
| spellingShingle | Ha Young Jo Hyun Ji Jang Chong Kun Cheon Ju Young Yoon Sukdong Yoo Jung Hyun Lee Jeong Eun Lee Ye Jin Kim Sejin Kim Hyun-Ji Kim Im Jeong Choi Min Jung Kwak Comparison of growth hormone therapy response according to the presence of growth hormone deficiency in children born small for gestational age with short stature in Korea: a retrospective cohort study BMC Pediatrics Small for gestational age Growth hormone deficiency Human growth hormone Growth disorder Child |
| title | Comparison of growth hormone therapy response according to the presence of growth hormone deficiency in children born small for gestational age with short stature in Korea: a retrospective cohort study |
| title_full | Comparison of growth hormone therapy response according to the presence of growth hormone deficiency in children born small for gestational age with short stature in Korea: a retrospective cohort study |
| title_fullStr | Comparison of growth hormone therapy response according to the presence of growth hormone deficiency in children born small for gestational age with short stature in Korea: a retrospective cohort study |
| title_full_unstemmed | Comparison of growth hormone therapy response according to the presence of growth hormone deficiency in children born small for gestational age with short stature in Korea: a retrospective cohort study |
| title_short | Comparison of growth hormone therapy response according to the presence of growth hormone deficiency in children born small for gestational age with short stature in Korea: a retrospective cohort study |
| title_sort | comparison of growth hormone therapy response according to the presence of growth hormone deficiency in children born small for gestational age with short stature in korea a retrospective cohort study |
| topic | Small for gestational age Growth hormone deficiency Human growth hormone Growth disorder Child |
| url | https://doi.org/10.1186/s12887-024-05339-0 |
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