In vivo Anti-arthritic Activity of Soft Coral Lobophytum sp. From Southeast Sulawesi in Freund’s Complete Adjuvant Induced Arthritis
Rheumatoid arthritis (RA) is a systemic, progressive, chronic autoimmune inflammatory disease that affects tissues, organs, and damages synovial joints. The RA can be treated with DMARD (disease modifying anti rheumatic drugs), such as methotrexate. However, the use of this drug long-term can cause...
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Diponegoro University; Association of Indonesian Coastal Management Experts
2024-09-01
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| Series: | Ilmu Kelautan |
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| Online Access: | https://ejournal.undip.ac.id/index.php/ijms/article/view/63361 |
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| author | Adryan Fristiohady Nurpajriani Nurpajriani Muhammad Hajrul Malaka Muhammad Ilyas Y Asniar Pascayantri Lidya Agriningsih Haruna La Ode Muh. Julian Purnama Rathapon Asasutjarit Idin Sahidin Agung Wibawa Mahatva Yodha |
| author_facet | Adryan Fristiohady Nurpajriani Nurpajriani Muhammad Hajrul Malaka Muhammad Ilyas Y Asniar Pascayantri Lidya Agriningsih Haruna La Ode Muh. Julian Purnama Rathapon Asasutjarit Idin Sahidin Agung Wibawa Mahatva Yodha |
| author_sort | Adryan Fristiohady |
| collection | DOAJ |
| description | Rheumatoid arthritis (RA) is a systemic, progressive, chronic autoimmune inflammatory disease that affects tissues, organs, and damages synovial joints. The RA can be treated with DMARD (disease modifying anti rheumatic drugs), such as methotrexate. However, the use of this drug long-term can cause side effects. Soft coral Lobophytum sp. has secondary metabolite compounds such as flavonoids, alkaloids, and terpenoids which has an anti-inflammatory activity, which beneficial for anti-rheumatoid arthritis agent. This study aims to determine the potential of anti RA in Lobophytum sp. using in vitro and in vivo. The anti-inflammatory assay for anti RA in vitro was performed by stabilization of human red blood cell (HRBC) membrane. In addition, anti RA was performed in arthritis model mice by induction of complete Freund’s adjuvant (CFA) by administering LEA once daily orally for 15 days. It was found that the ethyl acetate of Lobophytum sp. (LEA) reduced the haemolysis and increased the stability of HRBC membrane. Furthermore, LEA also showed anti RA by decreasing the edema in mouse paw at dose of 50 mg.kg-1 BW (LEA50), 100 mg.kg-1 BW (LEA100), and 200 mg.kg-1 BW (LEA200), respectively with 2.5 mg.kg-1 BW of methotrexate as positive control (C+) with P<0.05. Moreover, LEA200 demonstrated highest efficacy and showed no significant different with C+ (P>0.05). In conclusion, our research has shown that LEA has anti-inflammatory for treatment of rheumatoid arthritis from in vitro and in vivo studies. |
| format | Article |
| id | doaj-art-d07977bcf1a14dd18cecfaab4d8689e8 |
| institution | DOAJ |
| issn | 0853-7291 2406-7598 |
| language | English |
| publishDate | 2024-09-01 |
| publisher | Diponegoro University; Association of Indonesian Coastal Management Experts |
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| series | Ilmu Kelautan |
| spelling | doaj-art-d07977bcf1a14dd18cecfaab4d8689e82025-08-20T03:14:59ZengDiponegoro University; Association of Indonesian Coastal Management ExpertsIlmu Kelautan0853-72912406-75982024-09-0129338539210.14710/ik.ijms.29.3.385-39224477In vivo Anti-arthritic Activity of Soft Coral Lobophytum sp. From Southeast Sulawesi in Freund’s Complete Adjuvant Induced ArthritisAdryan Fristiohady0https://orcid.org/0000-0002-3499-0511Nurpajriani Nurpajriani1Muhammad Hajrul Malaka2Muhammad Ilyas Y3Asniar Pascayantri4Lidya Agriningsih Haruna5La Ode Muh. Julian Purnama6Rathapon Asasutjarit7Idin Sahidin8Agung Wibawa Mahatva Yodha9Department of Pharmacology and Clinical Pharmacy, Faculty of Pharmacy, Universitas Halu Oleo, IndonesiaDepartment of Pharmacology and Clinical Pharmacy, Faculty of Pharmacy, Universitas Halu Oleo, IndonesiaThammasat University Research Unit in Drug, Health Product Development and Application (DHP-DA), Department of Pharmaceutical Sciences, Faculty of Pharmacy, Thammasat University, ThailandDepartment of Pharmacology and Clinical Pharmacy, Faculty of Pharmacy, Universitas Halu Oleo, IndonesiaDepartment of Pharmacology and Clinical Pharmacy, Faculty of Pharmacy, Universitas Halu Oleo, IndonesiaThammasat University Research Unit in Drug, Health Product Development and Application (DHP-DA) Department of Pharmaceutical Sciences, Faculty of Pharmacy, Thammasat University, ThailandThammasat University Research Unit in Drug, Health Product Development and Application (DHP-DA) Department of Pharmaceutical Sciences, Faculty of Pharmacy, Thammasat University, ThailandThammasat University Research Unit in Drug, Health Product Development and Application (DHP-DA) Department of Pharmaceutical Sciences, Faculty of Pharmacy, Thammasat University, ThailandDepartment of Pharmaceutical Biology, Faculty of Pharmacy, Universitas Halu Oleo, IndonesiaDepartment of Pharmacy, Polytechnic Bina Husada, IndonesiaRheumatoid arthritis (RA) is a systemic, progressive, chronic autoimmune inflammatory disease that affects tissues, organs, and damages synovial joints. The RA can be treated with DMARD (disease modifying anti rheumatic drugs), such as methotrexate. However, the use of this drug long-term can cause side effects. Soft coral Lobophytum sp. has secondary metabolite compounds such as flavonoids, alkaloids, and terpenoids which has an anti-inflammatory activity, which beneficial for anti-rheumatoid arthritis agent. This study aims to determine the potential of anti RA in Lobophytum sp. using in vitro and in vivo. The anti-inflammatory assay for anti RA in vitro was performed by stabilization of human red blood cell (HRBC) membrane. In addition, anti RA was performed in arthritis model mice by induction of complete Freund’s adjuvant (CFA) by administering LEA once daily orally for 15 days. It was found that the ethyl acetate of Lobophytum sp. (LEA) reduced the haemolysis and increased the stability of HRBC membrane. Furthermore, LEA also showed anti RA by decreasing the edema in mouse paw at dose of 50 mg.kg-1 BW (LEA50), 100 mg.kg-1 BW (LEA100), and 200 mg.kg-1 BW (LEA200), respectively with 2.5 mg.kg-1 BW of methotrexate as positive control (C+) with P<0.05. Moreover, LEA200 demonstrated highest efficacy and showed no significant different with C+ (P>0.05). In conclusion, our research has shown that LEA has anti-inflammatory for treatment of rheumatoid arthritis from in vitro and in vivo studies.https://ejournal.undip.ac.id/index.php/ijms/article/view/63361rheumatoid arthritislobophytum sp.rheumatoid factorhrbc |
| spellingShingle | Adryan Fristiohady Nurpajriani Nurpajriani Muhammad Hajrul Malaka Muhammad Ilyas Y Asniar Pascayantri Lidya Agriningsih Haruna La Ode Muh. Julian Purnama Rathapon Asasutjarit Idin Sahidin Agung Wibawa Mahatva Yodha In vivo Anti-arthritic Activity of Soft Coral Lobophytum sp. From Southeast Sulawesi in Freund’s Complete Adjuvant Induced Arthritis Ilmu Kelautan rheumatoid arthritis lobophytum sp. rheumatoid factor hrbc |
| title | In vivo Anti-arthritic Activity of Soft Coral Lobophytum sp. From Southeast Sulawesi in Freund’s Complete Adjuvant Induced Arthritis |
| title_full | In vivo Anti-arthritic Activity of Soft Coral Lobophytum sp. From Southeast Sulawesi in Freund’s Complete Adjuvant Induced Arthritis |
| title_fullStr | In vivo Anti-arthritic Activity of Soft Coral Lobophytum sp. From Southeast Sulawesi in Freund’s Complete Adjuvant Induced Arthritis |
| title_full_unstemmed | In vivo Anti-arthritic Activity of Soft Coral Lobophytum sp. From Southeast Sulawesi in Freund’s Complete Adjuvant Induced Arthritis |
| title_short | In vivo Anti-arthritic Activity of Soft Coral Lobophytum sp. From Southeast Sulawesi in Freund’s Complete Adjuvant Induced Arthritis |
| title_sort | in vivo anti arthritic activity of soft coral lobophytum sp from southeast sulawesi in freund s complete adjuvant induced arthritis |
| topic | rheumatoid arthritis lobophytum sp. rheumatoid factor hrbc |
| url | https://ejournal.undip.ac.id/index.php/ijms/article/view/63361 |
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