Targeting GJB4 to inhibit tumor growth and induce ferroptosis in pancreatic cancer

Targeting GJB4 to inhibit tumor growth and induce ferroptosis in pancreatic cancer

BackgroundPancreatic cancer (PC) is a highly malignant type of cancer characterized by poor prognosis and high mortality rate. The role of gap junction protein beta 4 (GJB4) in PC has been scarcely reported. Therefore, the aim of this study was to investigate the function of GJB4 in PC cells and its...

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Bibliographic Details
Main Authors: Xiangru Zheng, Wenjun Li, Xiaoli Li, Qianyi Yao, Luquan Zheng, Rongrong Fan, Ping Bie
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-06-01
Series:Frontiers in Oncology
Subjects:
pancreatic cancer
GJB4
reactive oxygen species
ferroptosis
bioinformactics
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2025.1585236/full
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