Innovative nomogram for cervical cancer prediction: integrating high-risk HPV infection, p53 genotype, and blood routine parameters

Innovative nomogram for cervical cancer prediction: integrating high-risk HPV infection, p53 genotype, and blood routine parameters

BackgroundHuman papillomavirus (HPV) infection, especially high-risk types like HPV16 and HPV18, is a primary cause of cervical cancer. The p53 gene influences cellular response to DNA damage and has a functional polymorphism (rs1042522, p.Arg72Pro) that affects susceptibility to degradation by HPV...

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Bibliographic Details
Main Authors: Cheng Sun, Jun Zhang, Lili Pan, Shuang Yao, Fenghua Zhang, Linjuan Ji, Miaomei Yu, Guanghua Luo, Xiping Jiang
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-05-01
Series:Frontiers in Oncology
Subjects:
cervical cancer
blood routine parameters
p53
high-risk HPV
nomogram
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2025.1541928/full
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