Organic Solvents for Determination of Bacterial Endotoxin Index in Water-Insoluble Pharmaceutical Substances
Substances for manufacture of parenteral drugs require control by the «Bacterial Endotoxin» (BE) Index with the LAL-test. The aim of the study was to show possible applicability of organic solvents in BE determination by the gel-thromb test in case of water-insoluble pharmaceutical substances. The r...
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| Format: | Article |
| Language: | Russian |
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LLC "Publishing House OKI"
2020-05-01
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| Series: | Антибиотики и Химиотерапия |
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| Online Access: | https://www.antibiotics-chemotherapy.ru/jour/article/view/509 |
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| _version_ | 1850063373650100224 |
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| author | O. V. Shapovalova G. V. Dolgova N. P. Neugodova G. A. Sapozhnikova |
| author_facet | O. V. Shapovalova G. V. Dolgova N. P. Neugodova G. A. Sapozhnikova |
| author_sort | O. V. Shapovalova |
| collection | DOAJ |
| description | Substances for manufacture of parenteral drugs require control by the «Bacterial Endotoxin» (BE) Index with the LAL-test. The aim of the study was to show possible applicability of organic solvents in BE determination by the gel-thromb test in case of water-insoluble pharmaceutical substances. The results confirmed that ethyl alcohol practically had no effect on the endotoxin activity. In the routine assays it is advisable to test solutions of the substances at the alcohol concentration of 6% below. |
| format | Article |
| id | doaj-art-d06ec879cd4f4622b9d93fb3fdf6e772 |
| institution | DOAJ |
| issn | 0235-2990 |
| language | Russian |
| publishDate | 2020-05-01 |
| publisher | LLC "Publishing House OKI" |
| record_format | Article |
| series | Антибиотики и Химиотерапия |
| spelling | doaj-art-d06ec879cd4f4622b9d93fb3fdf6e7722025-08-20T02:49:36ZrusLLC "Publishing House OKI"Антибиотики и Химиотерапия0235-29902020-05-01589-104144508Organic Solvents for Determination of Bacterial Endotoxin Index in Water-Insoluble Pharmaceutical SubstancesO. V. Shapovalova0G. V. Dolgova1N. P. Neugodova2G. A. Sapozhnikova3Scientific Centre for Expertise of Medical Application ProductsScientific Centre for Expertise of Medical Application ProductsScientific Centre for Expertise of Medical Application ProductsScientific Centre for Expertise of Medical Application ProductsSubstances for manufacture of parenteral drugs require control by the «Bacterial Endotoxin» (BE) Index with the LAL-test. The aim of the study was to show possible applicability of organic solvents in BE determination by the gel-thromb test in case of water-insoluble pharmaceutical substances. The results confirmed that ethyl alcohol practically had no effect on the endotoxin activity. In the routine assays it is advisable to test solutions of the substances at the alcohol concentration of 6% below.https://www.antibiotics-chemotherapy.ru/jour/article/view/509water-insoluble pharmaceutical substancesbacterial endotoxinsethyl alcohol |
| spellingShingle | O. V. Shapovalova G. V. Dolgova N. P. Neugodova G. A. Sapozhnikova Organic Solvents for Determination of Bacterial Endotoxin Index in Water-Insoluble Pharmaceutical Substances Антибиотики и Химиотерапия water-insoluble pharmaceutical substances bacterial endotoxins ethyl alcohol |
| title | Organic Solvents for Determination of Bacterial Endotoxin Index in Water-Insoluble Pharmaceutical Substances |
| title_full | Organic Solvents for Determination of Bacterial Endotoxin Index in Water-Insoluble Pharmaceutical Substances |
| title_fullStr | Organic Solvents for Determination of Bacterial Endotoxin Index in Water-Insoluble Pharmaceutical Substances |
| title_full_unstemmed | Organic Solvents for Determination of Bacterial Endotoxin Index in Water-Insoluble Pharmaceutical Substances |
| title_short | Organic Solvents for Determination of Bacterial Endotoxin Index in Water-Insoluble Pharmaceutical Substances |
| title_sort | organic solvents for determination of bacterial endotoxin index in water insoluble pharmaceutical substances |
| topic | water-insoluble pharmaceutical substances bacterial endotoxins ethyl alcohol |
| url | https://www.antibiotics-chemotherapy.ru/jour/article/view/509 |
| work_keys_str_mv | AT ovshapovalova organicsolventsfordeterminationofbacterialendotoxinindexinwaterinsolublepharmaceuticalsubstances AT gvdolgova organicsolventsfordeterminationofbacterialendotoxinindexinwaterinsolublepharmaceuticalsubstances AT npneugodova organicsolventsfordeterminationofbacterialendotoxinindexinwaterinsolublepharmaceuticalsubstances AT gasapozhnikova organicsolventsfordeterminationofbacterialendotoxinindexinwaterinsolublepharmaceuticalsubstances |