A meta-analysis of genome-wide association scans identifies IL18RAP, PTPN2, TAGAP, and PUS10 as shared risk loci for Crohn's disease and celiac disease.

A meta-analysis of genome-wide association scans identifies IL18RAP, PTPN2, TAGAP, and PUS10 as shared risk loci for Crohn's disease and celiac disease.

Crohn's disease (CD) and celiac disease (CelD) are chronic intestinal inflammatory diseases, involving genetic and environmental factors in their pathogenesis. The two diseases can co-occur within families, and studies suggest that CelD patients have a higher risk to develop CD than the general...

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Main Authors: Eleonora A M Festen, Philippe Goyette, Todd Green, Gabrielle Boucher, Claudine Beauchamp, Gosia Trynka, Patrick C Dubois, Caroline Lagacé, Pieter C F Stokkers, Daan W Hommes, Donatella Barisani, Orazio Palmieri, Vito Annese, David A van Heel, Rinse K Weersma, Mark J Daly, Cisca Wijmenga, John D Rioux
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-01-01
Series:PLoS Genetics
Online Access:https://doi.org/10.1371/journal.pgen.1001283
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